Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

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Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC, SHIP1, SHIP2, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2.


  1. ^ Lioubin, M.N.; Algate, P.A.; Tsai, S.; Carlberg, K.; Aebersold, A.; Rohrschneider, L.R. (1996). "p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity". Genes Dev. 10: 1084–1095. doi:10.1101/gad.10.9.1084. PMID 8654924. 
  2. ^ Damen, J.E.; Liu, L.; Rosten, P.; Humphries, R.K.; Jefferson, A.B.; Majerus, P.W.; Krystal, G. (1996). "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase". Proc. Natl. Acad. Sci. USA. 93: 1689–1693. doi:10.1073/pnas.93.4.1689. PMC 40003Freely accessible. PMID 8643691. 
  3. ^ Giuriato, S.; Payrastre, B.; Drayer, A.L.; Plantavid, M.; Woscholski, R.; Parker, P.; Erneux, C.; Chap, H. (1997). "Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets". J. Biol. Chem. 272: 26857–26863. doi:10.1074/jbc.272.43.26857. PMID 9341117. 
  4. ^ Drayer, A.L.; Pesesse, X.; De Smedt, F.; Woscholski, R.; Parker, P.; Erneux, C. (1996). "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase". Biochem. Biophys. Res. Commun. 225: 243–249. doi:10.1006/bbrc.1996.1161. PMID 8769125. 
  5. ^ Pesesse, X.; Moreau, C.; Drayer, A.L.; Woscholski, R.; Parker, P.; Erneux, C. (1998). "The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity". FEBS Lett. 437 (3): 301–303. doi:10.1016/S0014-5793(98)01255-1. PMID 9824312. 

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