Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

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Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].


  1. ^ Niebuhr, K.; Giuriato, S.; Pedron, T.; Philpott, D.J.; Gaits, F.; Sable, J.; Sheetz, M.P.; Parsot, C.; Sansonetti, P.J.; Payrastre, B. (2002). "Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology". EMBO J. 21 (19): 5069–5078. doi:10.1093/emboj/cdf522. PMC 129044Freely accessible. PMID 12356723. 
  2. ^ Ungewickell, A.; Hugge, C.; Kisseleva, M.; Chang, S.C.; Zou, J.; Feng, Y.; Galyov, E.E.; Wilson, M.; Majerus, P.W. (2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proc. Natl. Acad. Sci. USA. 102 (52): 18854–18859. doi:10.1073/pnas.0509740102. PMC 1323219Freely accessible. PMID 16365287. 
  3. ^ Zou, J.; Marjanovic, J.; Kisseleva, M.V.; Wilson, M.; Majerus, P.W. (2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proc. Natl. Acad. Sci. USA. 104 (43): 16834–16839. doi:10.1073/pnas.0708189104. PMC 2040409Freely accessible. PMID 17940011. 
  4. ^ Mason, D.; Mallo, G.V.; Terebiznik, M.R.; Payrastre, B.; Finlay, B.B.; Brumell, J.H.; Rameh, L.; Grinstein, S. (2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase". J. Gen. Physiol. 129 (4): 267–283. doi:10.1085/jgp.200609656. PMC 2151621Freely accessible. PMID 17389247. 

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