Phosphatidylinositol deacylase

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phosphatidylinositol deacylase
EC number
CAS number 81604-94-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a phosphatidylinositol deacylase (EC is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-D-myo-inositol + H2O 1-acylglycerophosphoinositol + a carboxylate

Thus, the two substrates of this enzyme are 1-phosphatidyl-D-myo-inositol and H2O, whereas its two products are 1-acylglycerophosphoinositol and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-phosphatidyl-D-myo-inositol 2-acylhydrolase. Other names in common use include phosphatidylinositol phospholipase A2, and phospholipase A2.


  • Gray NC, Strickland KP (1982). "The purification and characterization of a phospholipase A2 activity from the 106,000 X g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol". Can. J. Biochem. 60 (2): 108–17. doi:10.1139/o82-015. PMID 7083039. 
  • Gray NC, Strickland KP (1982). "On the specificity of a phospholipase A2 purified from the 106,000 X g pellet of bovine brain". Lipids. 17 (2): 91–6. doi:10.1007/BF02535181. PMID 7087686.