Phycocyanobilin:ferredoxin oxidoreductase

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phycocyanobilin:ferredoxin oxidoreductase
Identifiers
EC number1.3.7.5
CAS number347401-12-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phycocyanobilin:ferredoxin oxidoreductase (PcyA, EC 1.3.7.5) is an enzyme that catalyzes the chemical reaction

(3Z)-phycocyanobilin + oxidized ferredoxin biliverdin IXalpha + reduced ferredoxin

Thus, the two substrates of this enzyme are (3Z)-phycocyanobilin and oxidized ferredoxin, whereas its two products are biliverdin IXalpha and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is (3Z)-phycocyanobilin:ferredoxin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D1E, 2DKE, and 2G18.

References[edit]

  • Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC (2001). "Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms". Plant Cell. 13 (4): 965&ndash, 78. doi:10.1105/tpc.13.4.965. PMC 135530. PMID 11283349.
  • Beale SI (1993). "Biosynthesis of phycobilins". Chem. Rev. 93 (2): 785&ndash, 802. doi:10.1021/cr00018a008.
  • Wu SH, McDowell MT, Lagarias JC (1997). "Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum". J. Biol. Chem. 272 (41): 25700&ndash, 5. doi:10.1074/jbc.272.41.25700. PMID 9325294.