Phytoene desaturase (neurosporene-forming)

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Phytoene desaturase (neurosporene-forming)
Identifiers
EC number 1.3.99.28
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phytoene desaturase (neurosporene-forming) (EC 1.3.99.28, 3-step phytoene desaturase, three-step phytoene desaturase, phytoene desaturase (ambiguous), CrtI (ambiguous)) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming).[1][2] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 3 acceptor all-trans-neurosporene + 3 reduced acceptor (overall reaction)
(1a) 15-cis-phytoene + acceptor all-trans-phytofluene + reduced acceptor
(1b) all-trans-phytofluene + acceptor all-trans-zeta-carotene + reduced acceptor
(1c) all-trans-zeta-carotene + acceptor all-trans-neurosporene + reduced acceptor

This enzyme is involved in carotenoid biosynthesis.

References[edit]

  1. ^ Raisig, A.; Bartley, G.; Scolnik, P.; Sandmann, G. (1996). "Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli". J. Biochem. 119 (3): 559–564. doi:10.1093/oxfordjournals.jbchem.a021278. PMID 8830054. 
  2. ^ Wang, C.W.; Liao, J.C. (2001). "Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution". J. Biol. Chem. 276 (44): 41161–41164. doi:10.1074/jbc.M105786200. PMID 11526111. 

External links[edit]