Pittsboro is a town in Chatham County, North Carolina, United States. The population was 3,743 at the 2010 census and 4,537 at the 2020 census. It is the county seat of Chatham County.

Chatham County is a county located in the Piedmont area of the U.S. state of North Carolina. It is also the location of the geographic center of North Carolina, northwest of Sanford. As of the 2020 census, the population was 76,285. Its county seat is Pittsboro.