Presbyterian Boys' Secondary School (PRESEC) is a secondary boarding school for boys. It is located in Legon, Accra, Ghana. It was founded in 1938, under the auspices of the Presbyterian Church of the Gold Coast. The Basel missionary-theologian, Nicholas Timothy Clerk (1862–1961), who served as the first Synod Clerk of the Presbyterian Church of the Gold Coast from 1918 to 1932, used his tenure to advocate for the establishment of the secondary school. The school has ties with its sister schools, Aburi Girls' Senior High School and Krobo Girls Senior High School.

Legon, a suburb of the Ghanaian city Accra, is situated about 12 kilometres (7.5 mi) north-east of the city center in the Ayawaso West Municipal District, a district in the Greater Accra Region of Ghana. Legon is home to the main campus of the University of Ghana. Ghanaians loosely refer to the University of Ghana simply as "Legon". Legon is also home to a few of Ghana's well known educational institutions such as Presbyterian Boys' Secondary School (PRESEC-Legon), Ghana Institute of Management and Public Administration and the Institute of Professional Studies. Legon is adjacent to one of the most prestigious residential suburbs of Accra - East Legon and only about 20 minutes drive from the Kotoka International Airport.