Protein phosphatase methylesterase-1

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Protein phosphatase methylesterase-1
Identifiers
EC number3.1.1.89
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1) is an enzyme with systematic name (phosphatase 2A protein)-leucine ester acylhydrolase.[1][2] This enzyme catalyses the following chemical reaction

[phosphatase 2A protein]-leucine methyl ester + H2O [phosphatase 2A protein]-leucine + methanol

A key regulator of protein phosphatase 2A.

References[edit]

  1. ^ Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (May 1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry. 274 (20): 14382–91. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.
  2. ^ Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y (April 2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell. 133 (1): 154–63. doi:10.1016/j.cell.2008.02.041. PMID 18394995.

External links[edit]