Proteinase 3

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PRTN3
PBB Protein PRTN3 image.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDsOMIM: 177020 MGI: 893580 HomoloGene: 120934 GeneCards: PRTN3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PRTN3
Genomic location for PRTN3
Band19p13.3Start840,999 bp[1]
End848,175 bp[1]
RNA expression pattern
PBB GE PRTN3 207341 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002777

NM_011178

RefSeq (protein)

NP_002768

NP_035308

Location (UCSC)Chr 19: 0.84 – 0.85 MbChr 10: 79.87 – 79.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.[5]

Function[edit]

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes, its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.[6]

References[edit]

  1. ^ a b c ENSG00000196415 GRCh38: Ensembl release 89: ENSG00000277804, ENSG00000196415 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057729 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701.
  6. ^ Hilhorst M, van Paassen P, Tervaert JW (October 2015). "Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis". Journal of the American Society of Nephrology. 26 (10): 2314–27. doi:10.1681/ASN.2014090903. PMC 4587702. PMID 25956510.

Further reading[edit]

External links[edit]