Protostadienol synthase

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Protostadienol synthase
Identifiers
EC number5.4.99.32
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Protostadienol synthase (EC 5.4.99.32, PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene (17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.

References[edit]

  1. ^ Lodeiro, S.; Xiong, Q.; Wilson, W.K.; Ivanova, Y.; Smith, M.L.; May, G.S.; Matsuda, S.P. (2009). "Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus". Org. Lett. 11: 1241–1244. doi:10.1021/ol802696a. PMID 19216560.

External links[edit]