Pteridine

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Pteridine
Skeletal formula of pteridine
Pteridine molecule
Pteridine molecule
Names
IUPAC name
pteridine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
KEGG
UNII
Properties
C6H4N4
Molar mass 132.13 g·mol−1
Melting point 139.5 °C (283.1 °F; 412.6 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pteridine is an aromatic chemical compound composed of fused pyrimidine and pyrazine rings. A pteridine is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure.

Synthesis of pteridine from 4,5-diaminopyrimidine and glyoxal.

Biochemistry[edit]

Pterins and flavins are classes of substituted pteridines that have important biological activity, especially in context of intermolecular energy transfer.[1]

Substituted pteridines are intermediates in the biosynthesis of dihydrofolic acid in many microorganisms.[2] The enzyme dihydropteroate synthetase converts pteridine and 4-aminobenzoic acid to dihydrofolic acid in the presence of glutamate. The enzyme dihydropteroate synthetase is inhibited by sulfonamide antibiotics.

See also[edit]

References[edit]

  1. ^ Kritsky, M. S; Telegina, T. A; Vechtomova, Y. L; Kolesnikov, M. P; Lyudnikova, T. A; Golub, O. A (2010). "Excited flavin and pterin coenzyme molecules in evolution". Biochemistry. Biokhimiia. 75 (10): 1200–16. PMID 21166638. 
  2. ^ Voet, D.; Voet, J.G. (2004). Biochemistry (3rd ed.). John Wiley & Sons. ISBN 0-471-39223-5