Putrescine is a foul-smelling organic chemical compound NH24NH2, related to cadaverine. The two compounds are responsible for the foul odor of putrefying flesh, but contribute to the odor of such processes as bad breath and bacterial vaginosis, they are found in semen and some microalgae, together with related molecules like spermine and spermidine. Putrescine and cadaverine were first described in 1885 by the Berlin physician Ludwig Brieger. In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors. Putrescine is produced on an industrial scale by hydrogenation of succinonitrile, produced by addition of hydrogen cyanide to acrylonitrile. Putrescine is reacted with adipic acid to yield the polyamide Nylon 46, marketed by DSM under the trade name Stanyl. Biotechnological production of putrescine from renewable feedstock is a promising alternative to the chemical synthesis. A metabolically engineered strain of Escherichia coli that produces putrescine at high titer in glucose mineral salts medium has been described.
Spermidine synthase uses S-adenosylmethioninamine to produce spermidine. Spermidine in turn gets converted to spermine. Putrescine is synthesized in small quantities by healthy living cells by the action of ornithine decarboxylase. Putrescine is synthesized biologically via two different pathways. In one pathway, arginine is converted into agmatine, with a reaction catalyzed by the enzyme arginine decarboxylase. N-carbamoylputrescine is converted into putrescine. In the second pathway, arginine is converted into ornithine and ornithine is converted into putrescine by ornithine decarboxylase; the polyamines, of which putrescine is one of the simplest, appear to be growth factors necessary for cell division. Putrescine is toxic in large doses. In rats it has a low acute oral toxicity of 2000 mg/kg body weight, with no-observed-adverse-effect level of 2000 ppm; when heated to decomposition, putrescine emits toxic fumes of NOx. Skatole Trimethylamine Putrescine MS Spectrum
Bunbury Mill is a watermill located to the east of the village of Bunbury, England. After being at risk of demolition, it has been restored as a working museum; the structure is designated by English Heritage as a Grade II listed building. There is evidence that a corn mill has been on the site since 1290; the present building dates from about 1844. During the 20th century the mill was used to produce animal feed, although some flour was still made. In 1960 the building was damaged by flood and, because of the cost of reconstruction and because of falling demand for its products, the mill closed; the land was bought by Nantwich Rural District Council. In 1966 there were plans to demolish the building, but local residents campaigned for the mill to be repaired as a job creation scheme; this was successful, the mill was restored to working order by 1977. It passed into the ownership of the North West Water Authority who reopened the mill as a working museum. In 1999 United Utilities added a classroom and toilet facilities, the building was used for school and heritage visitors.
The mill was closed by United Utilities in 2010 for financial reasons, the grounds and machinery were looked after by volunteers. The Bunbury Watermill Trust was established, in April 2012 the mill was given to the Trust, reopening it to visitors; the group Friends of Bunbury Mill has been established to support the work of the trustees. The mill stands on a sloping site with a single storey facing the road to the south, two storeys behind, it is constructed in red brick with a slate roof. On the south face is an elevated taking-in door under a small gable; the west and east sides are gabled, with three windows in the west side. The north side contains other openings; the mill pool lies to the south and the mill stream runs to the east. Bunbury Mill is open to visitors at advertised times. Tours of the working mill are available; the site includes a wildlife pool and 2 acres of grounds. Facilities include a visitor centre with a café and public toilets. Listed buildings in Bunbury, Cheshire List of museums in Cheshire Bunbury Mill - official site
Background was a Canadian journalistic television series which aired on CBC Television from 1959 to 1962. The series was an in-depth review of current news items, it replaced CBC's previous Sunday night journalistic series This Week. It was a forerunner to This Hour Has Seven Days, its first season was hosted by University of Saskatchewan political science professor Rick Hart. Hart, was inexperienced in broadcasting and left the series after the first season; the series was led in following seasons by a selection of journalists and analysts who included Arnold Beichman, Alistair Cooke, Philip Deane, Robert Fulford, Robert McKenzie, Michael Maclear and Malcolm Muggeridge. Documentaries featured on Background included features on various world regions, the United Nations, "The Rise and Fall of the Third Reich" by William L. Shirer. Douglas Leiterman produced "The Critical Years", a series within the Background series, for the final 1961-1962 seasons of the series. Background was produced by Cliff Solway, who complained of difficulty finding guests who could provide a sufficiently forceful presentation for the show.
For its first season, the series aired Sundays at 11:15 p.m. in a 25-minute time slot from 5 July 1959 to 26 June 1960. The next season, this was adjusted to a 20-minute time slot starting at 11:20 p.m. from 9 October 1960 to 1 January 1961. Background expanded to a 30-minute time slot at 10:00 p.m. Sundays from 19 February to 25 June 1961. In 1962, the series was randomly scheduled. Allan, Blaine. "Background". Queen's University. Archived from the original on 11 March 2010. Retrieved 7 May 2010