Pyridoxine 5'-phosphate synthase

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Pyridoxine 5'-phosphate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a pyridoxine 5'-phosphate synthase (EC is an enzyme that catalyzes the chemical reaction

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate pyridoxine 5'-phosphate + phosphate + 2 H2O

Thus, the two substrates of this enzyme are 1-deoxy-D-xylulose 5-phosphate and 3-amino-2-oxopropyl phosphate, whereas its 3 products are pyridoxine 5'-phosphate, phosphate, and H2O.


This enzyme belongs to the family of transferases, specifically those transferring nitrogenous groups transferring other nitrogenous groups.


The systematic name of this enzyme class is 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing). Other names in common use include pyridoxine 5-phosphate phospho lyase, PNP synthase, and PdxJ.

Biological role[edit]

This enzyme participates in vitamin B6 metabolism.


  • Garrido-Franco M (2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond". Biochim. Biophys. Acta. 1647 (1–2): 92–7. doi:10.1016/s1570-9639(03)00065-7. PMID 12686115. 
  • Garrido-Franco M, Laber B, Huber R, Clausen T (2002). "Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis". J. Mol. Biol. 321 (4): 601–12. doi:10.1016/S0022-2836(02)00695-2. PMID 12206776. 
  • Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS (1999). "Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein". FEBS Lett. 449 (1): 45–8. doi:10.1016/S0014-5793(99)00393-2. PMID 10225425. 
  • Franco MG, Laber B, Huber R, Clausen T (2001). "Structural basis for the function of pyridoxine 5'-phosphate synthase". Structure. 9 (3): 245–53. doi:10.1016/S0969-2126(01)00584-6. PMID 11286891.