1-piperazine is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor, it has negligible affinity for the dopamine D2, D3, D4 receptors and does not appear to have significant affinity for the α1-adrenergic receptors. A number of pyrimidinylpiperazine derivatives are drugs, including: Buspirone - anxiolytic Dasatinib - anticancer agent Eptapirone - anxiolytic Gepirone - anxiolytic Ipsapirone - anxiolytic Piribedil - antiparkinsonian agent Revospirone - anxiolytic Tandospirone - anxiolytic Tirilazad - neuroprotective agent Umespirone - anxiolytic Zalospirone - anxiolyticThe anxiolytics are classified as azapirones due to the azaspirodecanedione moiety in their structures. 1-PP is a common metabolite of all of the listed agents. Alnespirone and enilospirone, despite being azapirones, are not piperazines and therefore do not metabolize to 1-PP, while perospirone and tiospirone are piperazines, they are instead benzothiazole-substituted piperazines and do not metabolize to 1-PP either.
The Harlan Log House known as "The Log House," was built about 1715 by Joshua Harlan, is a well-preserved example of an English-style log cabin near Kennett Square, in Kennett Township, Chester County, United States. It is about a half mile west of the hamlet of Fairville. Joshua Harlan was the son of George Harlan, who arrived in Pennsylvania in 1687. Joshua was born in 1696 and was the cousin of the George Harlan, who built the Harlan House, about 12 miles north about 1724. Both houses are listed in the National Register of Historic Places; the core of the house was built about 1715 as a two-story square cabin. Although English settlers modelled their log cabins on the examples of Swedish settlers, the English versions were square rather than rectangular. An 1815 stone addition measures 19 feet by 15 feet, with a modern addition attached to the stone addition, it was added to the National Register of Historic Places in 1987
Jessore-5 is a constituency represented in the Jatiya Sangsad of Bangladesh since 2014 by Swapan Bhattacharjee, of the Awami League since 2018. The constituency encompasses Manirampur Upazila; the constituency was created for the first general elections in newly independent Bangladesh, held in 1973. Ahead of the 2008 general election, the Election Commission redrew constituency boundaries to reflect population changes revealed by the 2001 Bangladesh census; the 2008 redistricting altered the boundaries of the constituency. Ahead of the 2014 general election, the Election Commission expanded the boundaries of the constituency, it excluded one union parishad of Manirampur Upazila: Mancharpur. "People's Republic of Bangladesh". Psephos