1.
Regulation of therapeutic goods
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The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. In some countries, such as the United States, they are regulated at the level by a single agency. In other jurisdictions they are regulated at the level, or at both state and national levels by various bodies, as is the case in Australia. The role of therapeutic goods regulation is designed mainly to protect the health, regulation is aimed at ensuring the safety, quality, and efficacy of the therapeutic goods which are covered under the scope of the regulation. In most jurisdictions, therapeutic goods must be registered before they are allowed to be marketed, there is usually some degree of restriction of the availability of certain therapeutic goods depending on their risk to consumers. Therapeutic goods in Australia are regulated by the Therapeutic Goods Administration, there are 5 main categories, Normal Medicines - Cough, cold and fever medicines, antiseptics, vitamins and others. Sold freely in pharmacies and some large supermarkets, red Stripe Medicines - These medicines are sold only with medical prescription. Antibiotics, Anti allergenics, Anti inflammatories, and other medicines, in Brazil, governmental control is loose on this type, it is not uncommon to buy this type of prescription medicine over the counter without a prescription. Red Stripe Psychoactive Medicines - These medicines are only with a Special Control white medical prescription with carbon copy. The original must be retained by the pharmacist after the sale, Drugs include anti-depressants, anti-convulsants, some sleep aids, anti-psychotics and other non-habit-inducing controlled medicines. Though some consider them habit inducing, anabolic steroids are also regulated under this category, black Stripe Medicines - These medicines are sold only with the Blue B Form medical prescription, which is valid for 30 days and must be retained by the pharmacist after the sale. Includes sedatives, some anorexic inducers and other habit-inducing controlled medicines, includes amphetamines and other stimulants, opioids and other strong habit-forming controlled medicines. In Canada, regulation of goods are governed by the Food and Drug Act. In addition, the Controlled Drugs and Substances Act requires additional regulatory requirements for controlled drugs, the regulation of drugs in Burma is governed by the Food and Drug Administration and Food and Drug Board of Authority. The regulation of drugs in China is governed by the China Food, Medicines for Human Use in the United Kingdom are regulated by the Medicines and Healthcare products Regulatory Agency. The availability of drugs is regulated by classification by the MHRA as part of marketing authorisation of a product, Medicines in the Republic of Ireland are regulated according to the Misuse of Drugs Regulations 1988. Controlled drugs are divided into five categories based on their potential for misuse, cD1, cannabis, lysergamide, coca leaf, etc. Use prohibited except in limited circumstances where a license has been granted, CD2, amphetamine, methadone, morphine, fentanyl, oxycodone, tapentadol, etc
2.
Controlled Substances Act
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The Controlled Substances Act is the statute establishing federal U. S. drug policy under which the manufacture, importation, possession, use and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, the Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs. The legislation created five Schedules, with varying qualifications for a substance to be included in each, classification decisions are required to be made on criteria including potential for abuse, currently accepted medical use in treatment in the United States, and international treaties. The nation first outlawed addictive drugs in the early 1900s and the International Opium Convention helped lead international agreements regulating trade, the Food and Drugs Act of 1906 was the beginning of over 200 laws concerning public health and consumer protections. Others were the Federal Food, Drug, and Cosmetic Act, in 1969, President Richard Nixon announced that the Attorney General, John N. Shafer—to study cannabis abuse in the United States. It implies an overwhelming indictment of the behavior which we believe is not appropriate, the actual and potential harm of use of the drug is not great enough to justify intrusion by the criminal law into private behavior, a step which our society takes only with the greatest reluctance. According to David T. Courtwright, the Act was part of a reform package designed to rationalize. It eliminated mandatory minimum sentences and provided support for drug treatment, king notes that the rehabilitation clauses were added as a compromise to Senator Jim Hughes, who favored a moderate approach. The bill, as introduced by Senator Everett Dirksen, ran to 91 pages, since its enactment in 1970, the Act has been amended several times, The Medical Device Amendments of 1976. The Psychotropic Substances Act of 1978 added provisions implementing the Convention on Psychotropic Substances, the Controlled Substances Penalties Amendments Act of 1984. The Ryan Haight Online Pharmacy Consumer Protection Act of 2008 The Electronic Prescriptions for Controlled Substances 2010, the Controlled Substances Act consists of 2 subchapters. Subchapter II describes the laws for exportation and importation of controlled substances, again specifying fines, the Drug Enforcement Administration was established in 1973, combining the Bureau of Narcotics and Dangerous Drugs and Customs drug agents. When a petition is received by the DEA, the agency begins its own investigation of the drug and this request is sent to the Assistant Secretary of Health of HHS. Under certain circumstances, the Government may temporarily schedule a drug without following the normal procedure, an example is when international treaties require control of a substance. In addition,21 U. S. C. §811 allows the Attorney General to temporarily place a substance in Schedule I to avoid an imminent hazard to the public safety, in any case, once these proceedings are complete, the temporary order is automatically vacated. Unlike ordinary scheduling proceedings, such orders are not subject to judicial review. The CSA also creates a system of distribution for those authorized to handle controlled substances. The cornerstone of this system is the registration of all those authorized by the DEA to handle controlled substances
3.
ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
4.
Chemical formula
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These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the chemical formula CH3CH2OH
5.
Jmol
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Jmol is computer software for molecular modelling chemical structures in 3-dimensions. Jmol returns a 3D representation of a molecule that may be used as a teaching tool and it is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License version 2.0, a standalone application and a software development kit exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways, for example, molecules can be displayed as ball-and-stick models, space-filling models, ribbon diagrams, etc. Jmol supports a range of chemical file formats, including Protein Data Bank, Crystallographic Information File, MDL Molfile. There is also a JavaScript-only version, JSmol, that can be used on computers with no Java, the Jmol applet, among other abilities, offers an alternative to the Chime plug-in, which is no longer under active development. While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS9. Jmol requires Java installation and operates on a variety of platforms. For example, Jmol is fully functional in Mozilla Firefox, Internet Explorer, Opera, Google Chrome, fast and Scriptable Molecular Graphics in Web Browsers without Java3D
6.
Simplified molecular-input line-entry system
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The simplified molecular-input line-entry system is a specification in form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules, the original SMILES specification was initiated in the 1980s. It has since modified and extended. In 2007, a standard called OpenSMILES was developed in the open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. The Environmental Protection Agency funded the project to develop SMILES. It has since modified and extended by others, most notably by Daylight Chemical Information Systems. In 2007, a standard called OpenSMILES was developed by the Blue Obelisk open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, in July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is generally considered to have the advantage of being slightly more human-readable than InChI, the term SMILES refers to a line notation for encoding molecular structures and specific instances should strictly be called SMILES strings. However, the term SMILES is also used to refer to both a single SMILES string and a number of SMILES strings, the exact meaning is usually apparent from the context. The terms canonical and isomeric can lead to confusion when applied to SMILES. The terms describe different attributes of SMILES strings and are not mutually exclusive, typically, a number of equally valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol, algorithms have been developed to generate the same SMILES string for a given molecule, of the many possible strings, these algorithms choose only one of them. This SMILES is unique for each structure, although dependent on the algorithm used to generate it. These algorithms first convert the SMILES to a representation of the molecular structure. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database, there is currently no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, and these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES
7.
International Chemical Identifier
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Initially developed by IUPAC and NIST from 2000 to 2005, the format and algorithms are non-proprietary. The continuing development of the standard has supported since 2010 by the not-for-profit InChI Trust. The current version is 1.04 and was released in September 2011, prior to 1.04, the software was freely available under the open source LGPL license, but it now uses a custom license called IUPAC-InChI Trust License. Not all layers have to be provided, for instance, the layer can be omitted if that type of information is not relevant to the particular application. InChIs can thus be seen as akin to a general and extremely formalized version of IUPAC names and they can express more information than the simpler SMILES notation and differ in that every structure has a unique InChI string, which is important in database applications. Information about the 3-dimensional coordinates of atoms is not represented in InChI, the InChI algorithm converts input structural information into a unique InChI identifier in a three-step process, normalization, canonicalization, and serialization. The InChIKey, sometimes referred to as a hashed InChI, is a fixed length condensed digital representation of the InChI that is not human-understandable. The InChIKey specification was released in September 2007 in order to facilitate web searches for chemical compounds and it should be noted that, unlike the InChI, the InChIKey is not unique, though collisions can be calculated to be very rare, they happen. In January 2009 the final 1.02 version of the InChI software was released and this provided a means to generate so called standard InChI, which does not allow for user selectable options in dealing with the stereochemistry and tautomeric layers of the InChI string. The standard InChIKey is then the hashed version of the standard InChI string, the standard InChI will simplify comparison of InChI strings and keys generated by different groups, and subsequently accessed via diverse sources such as databases and web resources. Every InChI starts with the string InChI= followed by the version number and this is followed by the letter S for standard InChIs. The remaining information is structured as a sequence of layers and sub-layers, the layers and sub-layers are separated by the delimiter / and start with a characteristic prefix letter. The six layers with important sublayers are, Main layer Chemical formula and this is the only sublayer that must occur in every InChI. The atoms in the formula are numbered in sequence, this sublayer describes which atoms are connected by bonds to which other ones. Describes how many hydrogen atoms are connected to each of the other atoms, the condensed,27 character standard InChIKey is a hashed version of the full standard InChI, designed to allow for easy web searches of chemical compounds. Most chemical structures on the Web up to 2007 have been represented as GIF files, the full InChI turned out to be too lengthy for easy searching, and therefore the InChIKey was developed. With all databases currently having below 50 million structures, such duplication appears unlikely at present, a recent study more extensively studies the collision rate finding that the experimental collision rate is in agreement with the theoretical expectations. Example, Morphine has the structure shown on the right, as the InChI cannot be reconstructed from the InChIKey, an InChIKey always needs to be linked to the original InChI to get back to the original structure
8.
Synthetic cannabinoids
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Synthetic cannabinoids are a class of chemicals that are different from the cannabinoids found in cannabis but which also bind to cannabinoid receptors. They are often marketed as designer drugs or sold in products with claims that they give the effects of cannabis, when these chemicals are sprayed or otherwise soaked into a plant or other base material the blend is sometimes misleadingly referred to as synthetic marijuana. These synthetic marijuana products are sold for recreational drug use, when synthetic cannabinoid blends first went on sale in the early 2000s, it was thought that they achieved an effect through a mixture of natural herbs. They have been sold under brand names, online, in head shops. Studies have associated synthetic cannabinoid use with psychotic episodes days after use and these blends are often marketed as herbal incense or herbal smoking blends, and the products are usually consumed through smoking. Although synthetic cannabinoids may not produce results in drug tests for cannabis. The synthetic cannabinoids contained in these products have made illegal in many countries. Synthetic cannabinoids are used for drug use, however many were designed for research purposes. Studies are ongoing to examine their therapeutic potential, the drug is used in an attempt to get the effects of cannabis or similar effects. Part of the appeal of the drug is that it is marketed as being like natural cannabis, in comparison with cannabis, it is inexpensive and can be easy to get as a commercial product through convenience stores, tobacco shops, or head shops. A standard drug test will not identify a user of synthetic cannabinoids whereas that would happen with natural cannabis, Synthetic cannabinoids have been legal in the past, or at least, not illegal to sell or possess. There are many different chemicals which are called synthetic cannabinoids and many of them are regulated by different laws or not mentioned in laws, Synthetic cannabinoids frequently produce adverse effects which lead to hospitalization or referrals to poison control centers. Synthetic cannabinoids can be any of a number of different drugs, there is no way to describe general effects among all the different chemicals because they all have different effects. Many compounds have been banned in the U. S. and numerous countries, although loopholes remain. No official studies have been conducted on the effects of cannabinoids on humans. However, reports describing effects seen in patients seeking medical care after taking synthetic cannabinoids have been published, other symptoms included epileptic seizures, and acute psychosis. At least one death has been linked to overdose of synthetic cannabinoids and this may further explain the increased toxicity of synthetic cannabinoids compared to THC. Professor John W. Huffman, who first synthesised many of the used in synthetic cannabis mimics, is quoted as saying
9.
JWH-250
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JWH-250 or is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Other 2-substituted analogues such as the methyl, chloro and bromo compounds are also active, JWH-250 was discovered by, and named after the researcher Dr. John W. Huffman. He created JWH-250 and a number of compounds to research the structure. An ELISA immunoassay technique for detecting JWH-250 in urine has been reported, JWH-250 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard. AM-2201 JWH-073 JWH-200 List of JWH cannabinoids List of AM cannabinoids MEPIRAPIM SDB-001 THJ-2201
10.
JWH-007
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JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. Another drug similarly named JHW-007 is an analogue and atypical dopamine reuptake inhibitor. JWH-007 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, JWH-007 is illegal in Poland since 08.06.2010 on the basis of Ustawa z dnia 15 kwietnia 2011 r. O zmianie ustawy o przeciwdziałaniu narkomanii published in Dz. U,2011 nr 105 poz.614 As of October 2015 JWH-007 is a controlled substance in China. JWH-015 JWH-018 JWH-019 JWH-073 List of JWH cannabinoids
11.
RCS-4
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RCS-4, or 1-pentyl-3-indole, is a synthetic cannabinoid drug sold under the names SR-19, BTM-4, or Eric-4, but originally, OBT-199. RCS-4 is a potent cannabinoid receptor agonist, with EC50 values of 146 nM for human CB1 receptors, all methoxyphenyl regioisomers, and N-butyl homologues of RCS-4 and its regioisomers also display potent agonist activities at CB1 and CB2 receptors. RCS-4 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health and it was outlawed in Denmark on 11 March 2011. As of October 2015 RCS-4 is a substance in China. AM-630 AM-679 RCS-8 Pravadoline Structural scheduling of synthetic cannabinoids
12.
Cannabinoid
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A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid receptors in cells that alter neurotransmitter release in the brain. Ligands for these proteins include the endocannabinoids, the phytocannabinoids. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol, the psychoactive compound in cannabis. Cannabidiol is another constituent of the plant. There are at least 113 different cannabinoids isolated from cannabis, exhibiting varied effects, the discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate. These receptors are common in animals, and have found in mammals, birds, fish. At present, there are two types of cannabinoid receptors, termed CB1 and CB2, with mounting evidence of more. The human brain has more cannabinoid receptors than any other G protein-coupled receptor type, CB1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic system, including the hippocampus. They are also found in the cerebellum and in male and female reproductive systems. CB1 receptors are absent in the medulla oblongata, the part of the brain responsible for respiratory. CB1 is also found in the anterior eye and retina. CB2 receptors are found in the immune system, or immune-derived cells with the greatest density in the spleen. While found only in the nervous system, a report does indicate that CB2 is expressed by a subpopulation of microglia in the human cerebellum. CB2 receptors appear to be responsible for the anti-inflammatory and possibly other therapeutic effects of cannabis seen in animal models, the classical cannabinoids are concentrated in a viscous resin produced in structures known as glandular trichomes. At least 113 different cannabinoids have been isolated from the Cannabis plant To the right, the best studied cannabinoids include tetrahydrocannabinol, cannabidiol and cannabinol. All classes derive from cannabigerol-type compounds and differ mainly in the way this precursor is cyclized, the classical cannabinoids are derived from their respective 2-carboxylic acids by decarboxylation. CBG CBC CBL CBV THCV CBDV CBCV CBGV CBGM THC THCA CBD CBDA Tetrahydrocannabinol is the psychoactive component of the Cannabis plant. Delta-9-tetrahydrocannabinol and delta-8-tetrahydrocannabinol, mimic the actions of anandamide and 2-arachidonoylglycerol neurotransmitters produced naturally in the body and these cannabinoids produce the effects associated with cannabis by binding to the CB1 cannabinoid receptors in the brain
13.
Echinacea
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Echinacea /ˌɛkᵻˈneɪʃiə/ is a genus, or group of herbaceous flowering plants in the daisy family. The Echinacea genus has nine species, which are commonly called purple coneflowers and they are found only in eastern and central North America, where they are found growing in moist to dry prairies and open wooded areas. They have large, showy heads of flowers, blooming from early to late summer. The generic name is derived from the Greek word ἐχῖνος, meaning hedgehog and these flowering plants and their parts have different uses. Some species are cultivated in gardens for their showy flowers, Echinacea purpurea is used in folk medicine. Two of the species, E. tennesseensis and E. laevigata, are listed in the United States as endangered species, the DNA analysis allows researchers to reveal clear distinctions among species based on chemical differences in root metabolites. The research concluded that of the 40 genetically diverse populations of Echinacea studied, Echinacea species are herbaceous, drought-tolerant perennial plants growing up to 140 cm or 4 feet, in height. They grow from taproots, except E. purpurea, which grows from a caudex with fibrous roots. They have erect stems that in most species are unbranched, both the basal and cauline leaves are arranged alternately. The leaves are hairy with a rough texture, having uniseriate trichomes but sometimes they lack hairs. The basal leaves and the stem leaves have petioles. The leaf blades in different species may have one, three or five nerves, some species have linear to lanceolate leaves, and others have elliptic- to ovate-shaped leaves, often the leaves decrease in size as they progress up the stems. Leaf bases gradually increase in width away from the petioles or the bases are rounded to heart shaped, most species have leaf margins that are entire, but sometimes they are dentate or serrate. The flowers are collected together into single rounded heads at the ends of long peduncles, the inflorescences have crateriform to hemispheric shaped involucres which are 12–40 mm wide. The phyllaries, or bracts below the head, are persistent. The phyllaries are produced in a 2–4 series, the receptacles are hemispheric to conic. The paleae have orange to reddish purple ends, and are longer than the disc corollas, the paleae bases partially surrounding the cypselae, and are keeled with the apices abruptly constricted to awn-like tips. The ray florets number 8–21 and the corollas are purple to pale pink, white
14.
Caryophyllene
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It is usually found as a mixture with isocaryophyllene and α-humulene, a ring-opened isomer. Caryophyllene is notable for having a ring, as well as a trans-double bond in an 8-membered ring. The first total synthesis of caryophyllene in 1964 by E. J, corey was considered one of the classic demonstrations of the possibilities of synthetic organic chemistry at the time. Caryophyllene is one of the compounds that contributes to the spiciness of black pepper. 14-Hydroxycaryophyllene oxide was isolated from the urine of rabbits treated with -caryophyllene, the x-ray crystal structure of 14-hydroxycaryophyllene has been reported. The metabolism of caryophyllen progresses through -caryophyllene oxide since the compound also afforded 14-hydroxycaryophyllene as a metabolite. Caryophyllene → caryophyllene oxide → 14-hydroxycaryophyllene → 14-hydroxycaryophyllene oxide, caryophyllene oxide, in which the olefin of caryophyllene has become an epoxide, is the component responsible for cannabis identification by drug-sniffing dogs and is also an approved food flavoring. Antinociceptive, neuroprotective, anxiolytic and antidepressant and anti-alcoholism activity in in vitro studies, whether this compound is able to modulate inflammatory processes in humans via the endocannabinoid system is yet unknown. However, it is found to elicit significant neuroprotection by its anti-inflammatory, caryophyllene does not bind to the centrally expressed cannabinoid receptor type-1 and therefore does not exert psychoactive effects. Scientific evidence have been presented for non-cannabinoid plant components as putative antidotes to intoxicating effects of THC, that could increase its therapeutic index
15.
Cannabichromene
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Cannabichromene is a cannabinoid found in the Cannabis plant and therefore can be also described as a phytocannabinoid - from ancient Greek phyton = plant. It bears structural similarity to the other natural cannabinoids, including tetrahydrocannabinol, tetrahydrocannabivarin, cannabidiol and it is actually the second most concentrated cannabinoid in the plant, after tetrahydrocannabinol. Evidence has suggested that it may play a role in the anti-inflammatory and anti-viral effects of cannabis, cannabichromene may contribute to the overall analgesic effects of medical cannabis. A study done in March 2010 showed that CBC along with cannabidiol and tetrahydrocannabinol have antidepressant effects, another study showed that CBC helps promote neurogenesis. CBC is known to interact with receptors in the brain. It is widely known that the cannabinoids interact with the CB1 and CB2 receptors, CBC in particular is known to interact with the TRPV1 and TRPA1 receptors as well, which may result in some of its medicinal properties. Also, in mice, its antiinflammatory activity appears to be modulated by the administration of THC and is independent of the CB2 receptor and this suggests an interplay of the two molecules. It is not scheduled by the Convention on Psychotropic Substances and its boiling point is 220 degrees Celsius,428 degrees Fahrenheit. A study in Neurochemistry International suggested that cannabichromene might stimulate the growth of cells by stimulating adult neural stem progenitor cells. The study said our results suggest that CBC raises the viability of NSPCs while inhibiting their differentiation into astroglia, possibly through up-regulation of ATP, in a 2012 animal study, CBC was shown to normalize gastrointestinal hypermotility without reducing the transit time. The study notes that this is of clinical interest, as the only drugs available for intestinal dysmotility are often associated with constipation. In a 2015 study, CBC, together with other common phytocannabinoids, specifically CBC, cannabidivarin and tetrahydrocannabivarin showed promise to become highly efficient, novel anti-acne agents
16.
Cannabidiol
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Cannabidiol is one of at least 113 active cannabinoids identified in cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plants extract, Dravet syndrome is a rare form of epilepsy that is difficult to treat. It is a form of intractable epilepsy that begins in infancy. Initial seizures are most often prolonged events and in the year of life other seizure types begin to emerge. A number of profile and anecdotal reports have sparked interest in treatment of Dravet syndrome with cannabidiol. Some cannabis/hemp extract preparations containing CBD are marketed as dietary supplements, one such preparation is marketed under the tradename Charlottes Web Hemp Extract. GW Pharmaceuticals is seeking FDA approval to market a liquid formulation of pure plant-derived CBD, Epidiolex was granted fast-track status and is in late stage trials following positive early results from the drug. A2014 review stated that cannabidiol has been claimed, anecdotally, information in the review stated that there is no established mechanism of action and the lack of high-quality evidence in this area precluded conclusions being drawn. A2016 review states that because of the quality of available data. There is tentative evidence that CBD had an effect. Cannabidiol may also extend the duration of the effects of THC via inhibition of the cytochrome P450 CYP3A, cannabidiol has been found to act as an antagonist of the GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen. It has also shown to act as a 5-HT1A receptor partial agonist, and this action may be involved in the antidepressant, anxiolytic. It is a modulator of the μ and δ-opioid receptors as well. Cannabidiols pharmacological effects have additionally been attributed to PPARγ agonism and intracellular calcium release and it has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD. Despite this, the evidence in humans suggests no significant effect of CBD on THC plasma levels. Nabiximols is an aerosolized mist for oral administration containing a near 1,1 ratio of CBD, the drug was approved by Canadian authorities in 2005 to alleviate pain associated with multiple sclerosis. Epidiolex, a drug with cannabidiol as its active pharmaceutical ingredient, Epidiolex is an oil formulation of CBD extracted from the cannabis plant undergoing clinical trials for refractory epilepsy syndromes. Cannabidiol is insoluble in water but soluble in solvents such as pentane
17.
Cannabidivarin
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Cannabidivarin is a non-psychoactive cannabinoid found in Cannabis. It is a homolog of cannabidiol, with the side-chain shortened by two methylene bridges, plants with relatively high levels of CBDV have been reported in feral populations of C. indica from northwest India, and in hashish from Nepal. Similarly to CBD, it has 7 double bond isomers and 30 stereoisomers and it is not scheduled by Convention on Psychotropic Substances. It is being developed by GW Pharmaceuticals because of a demonstrated neurochemical pathway for previously-observed anti-epileptic. GW has begun a phase 2 trial for adult epilepsy, and is to begin trials of this CBDV product in children in 2016 in Australia, cannabinoids Cannabis Medical marijuana Erowid Compounds found in Cannabis sativa
18.
Cannabigerol
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Cannabigerol is a non-intoxicating cannabinoid found in the Cannabis genus of plants. CBG is the form of cannabigerolic acid, the parent molecule from which many other cannabinoids are made. CBG has been found to act as a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist and it also binds to the CB2 receptor as an antagonist. CBG does not trigger THC-like activity in mice, rats, gerbils and non-human primates, moreover, CBG was without effect up to 80 mg/kg in the mouse tetrad test of cannabimimetic activity. It has been shown to improve a model of inflammatory disease, ulcerative colitis. CBG induces production of the natural skin moisturizers, holding promise for dry-skin syndromes. Cannabigerol has been shown to relieve pressure, which may be of benefit in the treatment of glaucoma. CBG has been shown to have properties and may prove promising for the treatment of neurodegenerative diseases such as Huntington’s disease. CBG is known to have properties and research suggests that it might be effective against the superbug MRSA. CBG is showing promising properties in vitro for the treatment of a broad range of cancers including breast, liver, lung, pancreatic, skin, ovarian, renal, bladder. CBG is not scheduled by Convention on Psychotropic Substances, CBG is not scheduled at the federal level in the United States. The biosynthesis of CBG begins by loading a hexanoyl CoA onto a ketide synthetase assembly protein and subsequent condensation with three malonyl CoA molecules
19.
Cannabicyclol
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Cannabicyclol is a non-psychoactive cannabinoid found in Cannabis. CBL is a product like cannabinol. It is not scheduled by Convention on Psychotropic Substances
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Cannabinol
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Cannabinol is a psychoactive cannabinoid found only in trace amounts in Cannabis sativa and Cannabis indica. Pharmacologically relevant quantities are formed as a metabolite of tetrahydrocannabinol, CBN acts as a partial agonist at the CB1 receptors, but has a higher affinity to CB2 receptors, however, with lower affinities in comparison to THC. Degraded or oxidized cannabis products, such as low-quality baled cannabis and traditionally produced hashish, are high in CBN, cannabinol has been shown to have analgesic properties. Unlike other cannabinoids, CBN does not stem from cannabigerol but rather is the product of THC. If cannabis is exposed to air or ultraviolet light for a period of time. CBN is then formed by decarboxylation of CBNA, in contrast to THC, CBN has no double bond isomers nor stereoisomers. Both THC and CBN activate the CB1 and CB2 receptors, CBN is not listed in the list of scheduled controlled substances in the USA. It is also possible that CBN may not meet the standard of an analogue for the purposes of bringing forth a prosecution under the Federal Analogue Act. Erowid Compounds found in Cannabis sativa
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Tetrahydrocannabinol
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Tetrahydrocannabinol, or more precisely its main isomer -trans-Δ⁹-tetrahydrocannabinol, is the principal psychoactive constituent of cannabis. It can be a clear, amber or gold colored glassy solid when cold, like most pharmacologically-active secondary metabolites of plants, THC in Cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B absorption properties, which, it has been speculated, THC, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the UN Convention on Psychotropic Substances. It was listed under Schedule I in 1971, but reclassified to Schedule II in 1991 following a recommendation from the WHO, based on subsequent studies, the WHO has recommended the reclassification to the less-stringent Schedule III. Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs and it is specifically still listed under Schedule I by US federal law under the Controlled Substances Act signed by the US Congress in 1970. A pharmaceutical formulation is available by prescription in the U. S. dronabinol is the INN for a pure isomer of THC, -trans-Δ⁹-tetrahydrocannabinol, which is the main isomer found in cannabis. It is used to treat anorexia in people with HIV/AIDS as well as for refractory nausea and it is safe and effective for these uses. An overdose of dronabinol usually presents with lethargy, decreased motor coordination, slurred speech, there was a single death rated by the investigator as possibly related to treatment. This person had a seizure followed by aspiration pneumonia, the paper does not describe whether this was one of the subjects from the epilepsy trials. The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide, THC targets receptors in a manner far less selective than endocannabinoid molecules released during retrograde signaling, as the drug has a relatively low cannabinoid receptor efficacy and affinity. In populations of low cannabinoid receptor density, THC may act to antagonize endogenous agonists that possess greater receptor efficacy, THC is a lipophilic molecule and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue. THC, similarly to cannabidiol, albeit less potently, is an allosteric modulator of the μ-. Due to its agonistic activity, THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids. However, this form of tolerance appears to be irregular throughout mouse brain areas, THC is metabolized mainly to 11-OH-THC by the body. This metabolite is still psychoactive and is oxidized to 11-nor-9-carboxy-THC. In humans and animals, more than 100 metabolites could be identified, metabolism occurs mainly in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A4. More than 55% of THC is excreted in the feces and ~20% in the urine, the main metabolite in urine is the ester of glucuronic acid and THC-COOH and free THC-COOH. In the feces, mainly 11-OH-THC was detected, the discovery of THC, by a team of researchers from Hebrew University Pharmacy School, was first reported in 1964, with substantial later work reported by Raphael Mechoulam in June 1970
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Tetrahydrocannabinol-C4
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Tetrahydrocannabinol-C4, also known as THC-C4 and butyl-THC, is a homologue of tetrahydrocannabinol, the active component of cannabis. They are only different by the side chain being replaced by a butyl side chain. It is unknown whether THC-C4 is an agonist, partial agonist, the propyl analog, THCV, is a cannabinoid receptor type 1 and cannabinoid receptor type 2 antagonist, while THC is a CB1 agonist. THC-C4 has rarely been isolated from samples, but appears to be less commonly present than THC or THCV. It is metabolised in a manner to THC. Similarly to THC, it has 7 double bond isomers and 30 stereoisomers and it is not scheduled by Convention on Psychotropic Substances
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Tetrahydrocannabinolic acid
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Tetrahydrocannabinolic acid is a biosynthetic precursor of tetrahydrocannabinol, the active component of cannabis. When purified, it forms a crystal which is unstable in the presence of acids, heat, oxygen, THCA does not have any known psychoactive effects on humans in its own right. It does have antiinflammatory, neuroprotective, antiemetic and anti-prostate cancer effects and it inhibits COX-1 and COX-2 enzymes involved in inflammation in human colon cell cultures. It has also shown to decrease the amount of oxidative stress caused by impairment of mitochondria which is a major mechanism in neural degeneration in mouse mesencephalic cell cultures. Despite the ready decarboxylation by drying or heating ex vivo, conversion of THCA to THC in vivo appears to be very limited, consequently, it is believed to be important in less-psychoactive preparations of cannabis used for medical use, such as cannabis tea. THCA is not scheduled by the United Nations Convention on Psychotropic Substances, there is also a practical legal issue of potential THC contamination of THCA which should be considered. As mentioned above, THCA decarboxylates to form THC, a Schedule I controlled substance and this makes it possible that possession of THCA might lead to prosecution for possession of THC due to the presence of THC breakdown products in bulk THCA
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Tetrahydrocannabivarin
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Tetrahydrocannabivarin is a homologue of tetrahydrocannabinol having a propyl side chain instead of a pentyl group on the molecule, which makes it produce very different effects from THC. This terpeno-phenolic compound is naturally in Cannabis, sometimes in significant amounts. The psychoactive effects of THCV in Cannabis preparations are not well characterized, similarly to THC, THCV has 7 double bond isomers and 30 stereoisomers. Its melting point is <220 degrees Celsius, <428 degrees Fahrenheit, THCV levels up to 53. 7% of total cannabinoids have been reported. THCV is a cannabinoid receptor type 1 antagonist and cannabinoid receptor type 2 partial agonist, Δ8-THCV has also been shown to be a CB1 antagonist. Both papers describing the properties of THCV were demonstrated in murine models. Unlike THC, cannabidiol, and cannabichromene, THCV doesn’t begin as cannabigerolic acid, instead of combining with olivetolic acid to create CBGA, geranyl pyrophosphate joins with divarinolic acid, which has 2 less carbon atoms. Once CBGVA is created, the process continues exactly the same as it would for THC, CBGVA is broken down to tetrahydrocannabivarin carboxylic acid by the enzyme THCV synthase. At that point, THCVA can be decarboxylated with heat or UV light to create THCV, GW Pharmaceuticals is studying plant-derived tetrahydrocannabivarin for type 2 diabetes in addition to metformin. It is not scheduled by Convention on Psychotropic Substances, cannabinoids Rimonabant Tetrahydrocannabinol-C4 Cannabivarin Parahexyl Cannabis Medical cannabis Erowid Compounds found in Cannabis sativa
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Yangonin
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Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1, yangonin displays marked in vitro toxicity on human hepatocytes with approximately 40% reduction in viability based on an ethidium bromide assay. The predominant mode of cell death turned out to be rather than necrosis. No significant changes were observed in glutathione levels
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11-Hydroxy-THC
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11-Hydroxy-Δ9-tetrahydrocannabinol is the main active metabolite of Tetrahydrocannabinol which is formed in the body after cannabis is consumed. The conversion from THC to 11-OH-THC is relatively high when cannabis is consumed in the form of cannabis edibles and, compared to oral consumption, 11-OH-THC is more potent than THC and crosses the blood–brain barrier more easily. 11-Hydroxy-THC has been shown to be active in its own right and this might partially explain the biphasic effects of cannabis, whereby some effects such as increased appetite tend to be delayed rather than occurring immediately when the drug is consumed. Fresh cannabis contains Tetrahydrocannabinolic acid, which is converted into THC after heating, 11-Hydroxy-THC is subsequently metabolised further to 11-nor-9-carboxy-THC, which is not psychoactive but might still play a role in the analgesic and anti-inflammatory effects of cannabis
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Endocannabinoid
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Two primary endocannabinoid receptors have been identified, CB1, first cloned in 1990, and CB2, cloned in 1993. One other main endocannabinoid is 2-Arachidonoylglycerol which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD, 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase, the cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems. The neurons, neural pathways, and other cells where these molecules, enzymes, the endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, Cannabinoid binding sites exist throughout the central and peripheral nervous systems. The two most relevant receptors for cannabinoids are the CB1 and CB2 receptors, which are expressed predominantly in the brain, density of expression varies based on species and correlates with the efficacy that cannabinoids will have in modulating specific aspects of behavior related to the site of expression. For example, in rodents, the highest concentration of cannabinoid binding sites are in the ganglia and cerebellum. Binding has been demonstrated by 2-arachidonoylglycerol on the TRPV1 receptor suggesting that this receptor may be a candidate for the established response, in addition to CB1 and CB2, certain orphan receptors are known to bind endocannabinoids as well, including GPR18, GPR55, and GPR119. During neurotransmission, the pre-synaptic neuron releases neurotransmitters into the cleft which bind to cognate receptors expressed on the post-synaptic neuron. Expression appears to be exclusive, so both types of endocannabinoids are not co-synthesized. Evidence suggests that the influx of calcium into the post-synaptic neuron causes the activation of an enzyme called transacylase. This enzyme is suggested to catalyze the first step of endocannabinoid biosynthesis by converting phosphatidylethanolamine, experiments have shown that phospholipase D cleaves NAPE to yield anandamide. This process is mediated by bile acids, in NAPE-phospholipase D -knockout mice, cleavage of NAPE is reduced in low calcium concentrations, but not abolished, suggesting multiple, distinct pathways are involved in anandamide synthesis. The synthesis of 2-AG is less established and warrants further research, once released into the extracellular space by a putative endocannabinoid transporter, messengers are vulnerable to glial cell inactivation. While arachidonic acid is a substrate for leukotriene and prostaglandin synthesis, a neuropharmacological study demonstrated that an inhibitor of FAAH selectively increases anandamide levels in the brain of rodents and primates. Such approaches could lead to the development of new drugs with analgesic, anxiolytic-like and antidepressant-like effects, Cannabinoid receptors are G-protein coupled receptors located on the pre-synaptic membrane. The relative potency of different cannabinoids in inhibition of adenylyl cyclase correlates with their varying efficacy in behavioral assays and this inhibition of cAMP is followed by phosphorylation and subsequent activation of not only a suite of MAP kinases, but also the PI3/PKB and MEK/ERK pathway. In addition, CB1 activation has been demonstrated to increase the activity of transcription factors like c-Fos, the molecular mechanisms of CB1-mediated changes to the membrane voltage have also been studied in detail
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2-Arachidonoylglycerol
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2-Arachidonoylglycerol is an endocannabinoid, an endogenous agonist of the CB1 receptor. It is a formed from the omega-6 fatty acid arachidonic acid. It is present at high levels in the central nervous system. It has been found in bovine and human milk. The chemical was first described in 1994-1995, although it had discovered some time before that. The activities of Phospholipase C and diacylglycerol lipase mediate its formation, 2-AG is synthesized from arachidonic acid-containing diacylglycerol. 2-AG, unlike anandamide, is present at high levels in the central nervous system, it is the most abundant molecular species of monoacylglycerol found in mouse. Detection of 2-AG in brain tissue is complicated by the ease of its isomerization to 1-AG during standard lipid extraction conditions. It has been found in maternal bovine as well as human milk, shimon Ben-Shabat, of Ben-Gurion University, discovered the chemical. 2-AG was a chemical compound but its occurrence in mammals. 2-Arachidonoylglycerol, next with Anandamide, was the second endocannabinoid discovered, the cannabinoid established the existence of a cannabinoid neuromodulatory system in the nervous system. Unlike anandamide, formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C, 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0. 3nM, 2-AG induces a rapid, 2-AG is hydrolyzed in vitro by monoacylglycerol lipase, fatty acid amide hydrolase, and the uncharacterized serine hydrolase enzymes ABHD6 and ABHD12. The exact contribution of each of these enzymes to the termination of 2-AG signaling in vivo is unknown, there have been identified transport proteins for 2-arachidonoylglycerol and anandamide. These include the heat shock proteins and fatty acid binding proteins, 2-Arachidonoylglycerol is synthesized from arachidonic acid-containing diacylglycerol, which is derived from the increase of inositol phospholipid metabolism by the action of diacylglycerol lipase. 2-Arachidonoyl glyceryl ether Endocannabinoid transporters Dinh TP, Carpenter D, Leslie FM, brain monoglyceride lipase participating in endocannabinoid inactivation. Proceedings of the National Academy of Sciences of the United States of America
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2-Arachidonyl glyceryl ether
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2-Arachidonyl glyceryl ether is a putative endocannabinoid discovered by Lumír Hanuš and colleagues at the Hebrew University of Jerusalem, Israel. Its isolation from porcine brain and its structural elucidation and synthesis were described in 2001. Lumír Hanuš, Saleh Abu-Lafi, Ester Fride, Aviva Breuer, Zvi Vogel, Deborah E. Shalev, Irina Kustanovich, and Raphael Mechoulam found the endogenous agonist of the cannabinoid receptor type 1 in 2000. The discovery was 100 gram of porcine brain, was added to a mixture of 200 mL of chloroform and 200 mL of methanol,100 mL of Water was then added, and the mixing process continued for another minute. After this, the mixture was filtered, two layers then formed and the layer of water-methanol was separated and evaporated when pressure was reduced. Synaptosomal membranes were prepared from 250g of the brains of Sabra male rats, a Hewlett Packard G 1800B GCD system that has a HP-5971 GC with electron ionization detector was used. The production of the endocannabinoid is enhanced in normal, but not in endothelium-denuded rat aorta on reacting with carbachol and it potently reduces blood pressure in rats and may represent an endothelium-derived hypotension factor. 2-Arachidonyl glyceryl ethers structure can be determined by mass spectrometry and Rutherford backscattering spectrometry and it was confirmed by comparison with a synthetic sample of the endocannabinoid. It binds to the Cannabinoid receptor type 1, which causes sedation, hypothermia, intestinal immobility, the endocannabinoid exhibits Ki values of 21.2 nM and >3 µM at the Cannabinoid receptor type 1 and the peripheral cannabinoid receptors. The presence of 2-AGE in body tissue is disputed, 2-AGE binds with a Ki of 21 nM to the CB1 receptor and 480 nM to the CB2 receptor. It shows agonistic behaviour on both receptors and is a partial agonist for the TRPV1 channel, after binding to CB2 receptors it inhibits adenylate cyclase and stimulates ERK-MAPK and regulates calcium transients. In comparison to 2-arachidonoyl glycerol, noladin is metabolically more stable resulting in a longer half-life and it lowers Intraocular pressure, increases the uptake of GABA in the globus pallidus of rats and is neuroprotective by binding to and activation of PPARα. 2-Arachidonoylglycerol Commercial supplier of Noladin ether
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2-Oleoylglycerol
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2-Oleoylglycerol is a monoacylglycerol that is found in biologic tissues. Its synthesis is derived from diacylglycerol precursors and it is metabolized to oleic acid and glycerol primarily by the enzyme monoacylglycerol lipase. In 2011, 2OG was found to be a ligand to GPR119. 2OG has been shown to increase glucagon-like peptide-1 and gastric inhibitory polypeptide levels following administration to the small intestine
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N-Arachidonoyl dopamine
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N-Arachidonoyl dopamine is an endocannabinoid that acts as an agonist of the CB1 receptor and the transient receptor potential V1 ion channel. NADA was first described as a putative endocannabinoid in 2000 and was identified as an endovanilloid in 2002. NADA is an arachidonic acid based lipid found in the brain of rats, with especially high concentrations in the hippocampus, cerebellum. It activates the TRPV1 channel with an EC50 of approximately of 50nM which makes it the putative endogenous TRPV1 agonist, in mice, NADA was shown to induce the tetrad of physiological paradigms associated with cannabinoids, hypothermia, hypo-locomotion, catalepsy, and analgesia. NADA has been found to play a role in both the peripheral and central nervous systems, and displays antioxidant and neuroprotectant properties. NADA has also implicated in smooth muscle contraction and vasorelaxation in blood vessels. NADA also promotes the inflammatory resolution of human endothelial cells activated by endogenous and exogenous inflammatory mediators. Furthermore, NADA also displays inhibitory activity in HIV-1 replication assays, finally, NADA can prevent the degranulation and release of TNF from RBL- 2H3 mast cells treated with an IgE-antigen complex. Together, theses studies show that physiological functions attributed to NADA are multifaceted, and include the ability to modulate the immune response
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Oleamide
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Oleamide is an organic compound with the formula CH37CH=CH7CNH2. It is the derived from the fatty acid oleic acid. It is a waxy solid. Sometimes labeled as a fatty acid amide, it is biosynthesized from N-oleoylglycine. In terms of occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the fluid during sleep deprivation. It has been considered as a treatment for mood and sleep disorders. In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems, synthetic oleamide has a variety of industrial uses including as a slip agent, a lubricant, and a corrosion inhibitor. Oleamide was found to leaking out of plastics in laboratory experiments. Since polypropylene is used in a number of food containers such as those for yogurt. Analysis of 44 products containing synthetic cannabinoid drugs marketed as herbal incense revealed oleamide in 7 of the products tested, anandamide Fatty acid amide hydrolase Virodhamine
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