RNASEH1

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RNASEH1
PDB 2qk9 EBI.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNASEH1, H1RNA, RNH1, PEOB2, ribonuclease H1
External IDsMGI: 1335073 HomoloGene: 2202 GeneCards: RNASEH1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for RNASEH1
Genomic location for RNASEH1
Band2p25.3Start3,544,793 bp[1]
End3,558,616 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286834
NM_001286837
NM_002936

NM_001286865
NM_011275

RefSeq (protein)

NP_001273763
NP_001273766
NP_002927

NP_001273794
NP_035405

Location (UCSC)Chr 2: 3.54 – 3.56 MbChr 12: 28.65 – 28.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.[5][6][7] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171865 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020630 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: ribonuclease H1". 
  6. ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics. 79 (6): 818–23. doi:10.1006/geno.2002.6776. PMID 12036296. 
  7. ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell. 28 (2): 264–76. doi:10.1016/j.molcel.2007.08.015. PMID 17964265. 

Further reading[edit]