RNA polymerase V

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RNA polymerase V is a multisubunit plant specific RNA polymerase found in nucleus. Together with RNA polymerase IV required for normal function and biogenesis of small interferring RNA (siRNA). Pol V is involved in siRNA-directed DNA methylation pathway which leads to heterochromatic silencing.[1]

RNA polymerase V is composed of 12 subunits that are paralogous to RNA polymerase II subunits. Two largest subunits (catalytic site) is the most conserved region sharing similarity with eukaryotic and bacterial polymerases.[2]

References[edit]

  1. ^ Wierzbicki, A; Haag, J; Pikaard, CS (2008). "Noncoding transcription by RNA Polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes". Cell. 135: 635–648. doi:10.1016/j.cell.2008.09.035. PMC 2602798Freely accessible. PMID 19013275. 
  2. ^ Ream, TS; Haag, JR; Wierzbicki, AT; Nicora, CD; Norbeck, AD; Zhu, JK; Hagen, G; Guilfoyle, TJ; Pasa-Tolić, L; Pikaard, CS. "Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal their origins as specialized forms of RNA polymerase II". Mol Cell. 33: 192–203. doi:10.1016/j.molcel.2008.12.015. PMC 2946823Freely accessible. PMID 19110459.