Relaxin/insulin-like family peptide receptor 4

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Aliases RXFP4, GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4
External IDs MGI: 2182926 HomoloGene: 18775 GeneCards: RXFP4
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RXFP4
Genomic location for RXFP4
Band 1q22 Start 155,941,710 bp[1]
End 155,942,949 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 155.94 – 155.94 Mb Chr 1: 88.65 – 88.65 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.[5]


GPR100 is a member of the rhodopsin family of G protein-coupled receptors GPRs (Fredriksson et al., 2003).[supplied by OMIM][5]

See also[edit]


External links[edit]

Further reading[edit]

  • Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (May 2005). "Receptors for relaxin family peptides". Annals of the New York Academy of Sciences. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688. 
  • Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (March 2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacological Reviews. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. 
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW (December 2003). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". The Journal of Biological Chemistry. 278 (50): 50765–70. doi:10.1074/jbc.M308996200. PMID 14522967. 
  • Boels K, Schaller HC (November 2003). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". British Journal of Pharmacology. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC 1574110Freely accessible. PMID 14530218. 
  • Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (November 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. 
  • Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (January 2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Molecular Pharmacology. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. 
  • Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.