Santa Fe de la Vera Cruz is the capital city of the province of Santa Fe, Argentina. It is situated in north-eastern Argentina, near the junction of the Paraná and Salado rivers. It lies 15 kilometres (9.3 mi) from the Hernandarias Subfluvial Tunnel that connects it to the city of Paraná. The city is also connected by canal with the port of Colastiné on the Paraná River. Santa Fe de la Vera Cruz has about 391,164 inhabitants per the 2010 census [INDEC]. The metropolitan area has a population of 653,073, making it the eighth largest in Argentina.

The Province of Santa Fe is a province of Argentina, located in the center-east of the country. Neighboring provinces are from the north clockwise Chaco, Corrientes, Entre Ríos, Buenos Aires, Córdoba, and Santiago del Estero. Together with Córdoba and Entre Ríos, the province is part of the economico-political association known as the Center Region.