Santiago is a province which currently comprises one of the 32 provinces of the Dominican Republic. It is divided into 10 municipalities and its capital city is Santiago de los Caballeros. Located in north-central Dominican Republic, in the Cibao region, it is bordered by the provinces of Valverde to the north-west, Puerto Plata to the north, Espaillat and La Vega to the east, San Juan to the south and Santiago Rodríguez to the west.

The Dominican Republic is divided into thirty-one provincias, while the national capital, Santo Domingo, is contained within its own Distrito Nacional.