The Saturn Awards are American awards presented annually by the Academy of Science Fiction and Horror Films. The awards were referred to as Golden Scrolls; the Saturn Awards were created in 1973. The Saturn Awards were devised by Donald A. Reed in 1973, who felt that work in films in the genre of science fiction at that time lacked recognition within the established Hollywood film industry's award system; the award given was a Golden Scroll certificate. In the late 1970s, the award was changed to be a representation of the planet Saturn, with its ring composed of film; the Saturn Awards are voted upon by members of the presenting Academy. The Academy is a non-profit organization with membership open to the public, its President and Executive Producer is Robert Holguin, Producer/Writers Bradley Marcus and Kevin Marcus Its members include filmmakers JJ Abrams, Bryan Singer, Steven Spielberg, Bryan Fuller, Mark A. Altman, Vince Gilligan and James Cameron, among others. Although the Award still focuses on films and television in the science fiction and horror categories, the Saturns have recognized productions in other dramatic genres.
There are special awards for lifetime achievement in film production. The Saturn Awards are criticized for having a broad and inconsistent definition of genres, as well as for nominating and awarding movies not related to sci-fi, fantasy or horror. Best Streaming Superhero Series Best Streaming Science Fiction, Action & Fantasy Series Best Streaming Horror & Thriller Series Best Actor in Streaming Presentation Best Actress in Streaming Presentation Best Supporting Actor in Streaming Presentation Best Supporting Actress in Streaming Presentation Best DVD or Blu-ray Release Best DVD or Blu-ray Special Edition Release Best Classic Film DVD Release Best Television DVD Release Best DVD or Blu-ray Collection Best Retro Television Series on DVD The George Pal Memorial Award The Life Career Award The President's Memorial Award Special Recognition Award Breakthrough Performance Award Best Low-Budget Film Best Network Television Series Best Syndicated/Cable Television Series Best International Series Best Youth-Oriented Television Series Best New Media Television Series Best Television Presentation 1Star Wars was nominated for 16 awards, won 12.
The actual number of nominations include two nominations as part of compilations. 214 wins for Star Wars, 4 wins for The Empire Strikes Back, 5 wins for Return of the Jedi, 2 wins for The Phantom Menace, 2 wins for Attack of the Clones, 2 wins for Revenge of the Sith, 8 wins for The Force Awakens, 3 wins for Rogue One, 3 wins for The Last Jedi, 1 win for a compilation comprising several films of the franchise. 38 nominations for Iron Man, 1 nomination for The Incredible Hulk, 4 nominations for Iron Man 2, 4 nominations for Thor, 7 nominations for Captain America: The First Avenger, 6 nominations for The Avengers, 5 nominations for Iron Man 3, 5 nominations for Thor: The Dark World, 11 nominations for Captain America: The Winter Soldier, 9 nominations for Guardians of the Galaxy, 4 nominations for Avengers: Age of Ultron, 6 nominations for Ant-Man, 8 nominations for Captain America: Civil War, 10 nominations for Doctor Strange, 4 nominations for Guardians of the Galaxy Vol. 2, 4 nominations for Spider-Man: Homecoming, 2 nominations for Thor: Ragnarok, 14 nominations for Black Panther, 2 nominations for Avengers: Infinity War, 3 nominations for Captain Marvel, 14 nominations for Avengers: Endgame.
Chakravakam is a 1974 Telugu drama film based on the novel titled Chakravakam written by Koduri Kausalya Devi. Sobhan Babu Vanisree Chandrakala S. V. Ranga Rao Nagabhushanam Allu Ramalingaiah Krishna Kumari Rajasulochana Padmanabham Sreedhar "Ee Nadila Naa Hrudayam Parugulu Teestundi" "Kothaga Pellaina Kurravaniki Pattapagale Tondara" "Veenaleni Teeganu Neevuleni Bratukunu" "Veenalona Teegalona Ekkadunnadi Ragamu" The film ran for 200 days in Hyderabad. Chakravakam on IMDb
Deepak Vinayak is an Award Winning Indian Australian community leader from Melbourne. He was appointed as the People of Australia Ambassador by Australian Prime Minister Julia Gillard for two consecutive terms in 2012 and 2013. Deepak completed BTech in civil engineering from Punjab of India and migrated to Australia in 1996, he has graduated from Victoria University with a Diploma of Engineering in Advanced Trade. He works for the Metro Trains Melbourne, he was appointed People of Australia Ambassador for two times 2012 and 2013 by Australian Prime Minister Julia Gillard. Deepak has been a four-time Australia Day Ambassador, he was a member of Regional Advisory Council for North and West Metropolitan at Victorian Multicultural Commission, State Government of Victoria. He founded South Asian Community Link Group-Australasia, South Asian Youth Connect Australasia and Global Organization for People of Indian Origin Chapter in Melbourne to engage with South Asian Australians in Victoria, he has extended support in community work by youth, engaged with multifaith communities, has hosted community gathering to engage policy makers with local community and has partnered in Suicide Prevention.
He is an R U OK and White Ribbon Ambassador. He has been recognised as a Community Champion by Victoria University Medal of the Order of Australia 2018 Pride of Australia Medal Victoria Victorian Multicultural Commission, Government of Victoria, Multicultural Champion of Victoria is nominated as a Multicultural Champion for service to multiculturalism in Victoria, 2018 Australia Day Ambassador for consecutively four times during 2014–17, National Australia Day Council Victorian Multicultural Commission, Government of Victoria, Victoria's Multicultural Awards for Excellence in category of Meritorious Service to the Community–Individuals, 2015 People of Australia Ambassador for two terms, 2012 and 2013, appointed by Prime Minister of Australia Victorian Multicultural Commission, Government of Victoria, Victoria's Multicultural Awards for Excellence in category of Service Delivery to Multicultural Community-Individuals, 2010 Official website
Lipinski's rule of five known as Pfizer's rule of five or the rule of five, is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would make it a orally active drug in humans. The rule was formulated by Christopher A. Lipinski in 1997, based on the observation that most orally administered drugs are small and moderately lipophilic molecules; the rule describes molecular properties important for a drug's pharmacokinetics in the human body, including their absorption, distribution and excretion. However, the rule does not predict; the rule is important to keep in mind during drug discovery when a pharmacologically active lead structure is optimized step-wise to increase the activity and selectivity of the compound as well as to ensure drug-like physicochemical properties are maintained as described by Lipinski's rule. Candidate drugs that conform to the RO5 tend to have lower attrition rates during clinical trials and hence have an increased chance of reaching the market.
Lipinski's rule states that, in general, an orally active drug has no more than one violation of the following criteria: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular mass less than 500 daltons An octanol-water partition coefficient that does not exceed 5Note that all numbers are multiples of five, the origin of the rule's name. As with many other rules of thumb, such as Baldwin's rules for ring closure, there are many exceptions. In an attempt to improve the predictions of druglikeness, the rules have spawned many extensions, for example the Ghose filter: Partition coefficient log P in −0.4 to +5.6 range Molar refractivity from 40 to 130 Molecular weight from 180 to 480 Number of atoms from 20 to 70 Veber's Rule further questions a 500 molecular weight cutoff. The polar surface area and the number of rotatable bonds has been found to better discriminate between compounds that are orally active and those that are not for a large data set of compounds in the rat.
In particular, compounds which meet only the two criteria of: 10 or fewer rotatable bonds and Polar surface area no greater than 140 Å2are predicted to have good oral bioavailability. During drug discovery and molecular weight are increased in order to improve the affinity and selectivity of the drug candidate. Hence it is difficult to maintain drug-likeness during hit and lead optimization. Hence it has been proposed that members of screening libraries from which hits are discovered should be biased toward lower molecular weight and lipophility so that medicinal chemists will have an easier time in delivering optimized drug development candidates that are drug-like. Hence the rule of five has been extended to the rule of three for defining lead-like compounds. A rule of three compliant compound is defined as one that has: octanol-water partition coefficient log P not greater than 3 molecular mass less than 300 daltons not more than 3 hydrogen bond donors not more than 3 hydrogen bond acceptors not more than 3 rotatable bonds Biopharmaceutics Classification System Chemical structure Chemicalize.org § List of the predicted structure based properties Fragment-based lead discovery QSAR Interactive Rule of Five calculator Free online calculations of Hydrogen bond donor/acceptor and logP using ChemAxon's Marvin and Calculator Plugins – requires Java Calculation of Druglikeness – requires Java
Roston Lamar Chase is a Barbadian cricketer who plays for the West Indies national cricket team and Barbadian national side in domestic. A batting allrounder, he is a right-arm off spin bowler. In July 2017, he was named Cricketer of the Year and Test Cricketer of the Year by the West Indies Players' Association. From Christ Church Parish, Chase made his senior debut for Barbados during the 2010–11 Regional Four Day Competition, aged 18. After two matches in his debut season, he did not appear again until the 2012–13 competition, although he has since become a regular in the team. During the 2014–15 season, Chase scored a maiden first-class century, 120 not out from 241 balls against the Windward Islands, he finished the season with 534 runs from eight matches, which placed him fourth for Barbados and eighth in the overall competition. Chase continued his good form during the 2015–16 season, being named man of the match against the Leeward Islands after making 136 not out in his team's first innings.
In June 2018, he was named the Best Regional Limited-Overs Cricketer of the Year at the annual Cricket West Indies' Awards. Ahead of the 2018 Caribbean Premier League, he was named as one of five players to watch in the tournament. In October 2018, Cricket West Indies awarded him a red-ball contract for the 2018–19 season. In July 2016, he was named in the West Indies squad for their Test series against India, he made his Test debut for the West Indies on 21 July 2016. In his second Test match, Chase picked up his maiden five-wicket haul and scored a century to stave off a strong Indian bowling attack. In June 2017, he was named in the West Indies One Day International squad for their series against Afghanistan, he made his ODI debut for the West Indies against Afghanistan on 9 June 2017. On 26 January 2019, Chase achieved bowling figures of 8/60 in the fourth innings of the first Test against England in Barbados adding a 54 with the bat in the first innings. In May 2019, Cricket West Indies named him as one of ten reserve players in the West Indies' squad for the 2019 Cricket World Cup.
Kyasamballi Chengaluraya Reddy was the first Chief Minister of Karnataka. K. C. Reddy was born on 4th into Vokkaliga family in Kyasambali village, Kolar district, he was a revolutionary from childhood and participated in many protests against British rule in India. After graduating in law, Reddy along with other political activists, founded the Praja Paksha in 1930; the aim of this party was to achieve responsible government in the Princely state of Mysore. The party gained support in rural areas as it highlighted the issues of farmers; the Praja Paksha and Praja Mitra Mandali joined to form the Praja Samyukta Paksha in 1934. Reddy served as its president from 1935 to 1937; the federation merged with the Indian National Congress and participated in the Indian independence movement. Reddy served as the president of Mysore Congress twice, in 1937–38 and 1946–47, he was a member of the Constituent Assembly of India. After independence of India in 1947, he was at the forefront of the Mysore Chalo movement seeking responsible state government in Mysore State and went on to become the first Chief Minister of the state.
He served in this position from 1947 to 1952. Reddy was elected as a member of the Mysore Legislative Assembly in 1952. Subsequently, he served as a member of the Rajya Sabha from 1952 to 1957 and as a member of the Lok Sabha, representing Kolar from 1957 to 1962. During this period, he served as Union Minister for Housing and Supplies and as Union Minister for Commerce and Industries, he served as Governor of Madhya Pradesh from 1965 to 1971. Reddy's birth centenary was commemorated in 2002 when his contribution towards the development of Karnataka was hailed. List of Chief Ministers of Karnataka List of Governors of Madhya Pradesh 10. Http://www.reddysociety.com/?q=node/35