Secoisolariciresinol dehydrogenase

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Secoisolariciresinol dehydrogenase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Secoisolariciresinol dehydrogenase (EC is an enzyme with systematic name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

(-)-secoisolariciresinol + 2 NAD+ (-)-matairesinol + 2 NADH + 2 H+

This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.


  1. ^ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". J. Biol. Chem. 276 (16): 12614–12623. doi:10.1074/jbc.M008622200. PMID 11278426. 
  2. ^ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". J. Biol. Chem. 280 (13): 12917–12926. doi:10.1074/jbc.M413266200. PMID 15653677. 
  3. ^ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Org. Biomol. Chem. 4 (5): 808–816. doi:10.1039/b516563f. PMID 16493463. 

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