Segesterone

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Segesterone
Segesterone.svg
Clinical data
Synonyms 17α-Hydroxy-16-methylene-19-norprogesterone; 16-Methylene-17α-hydroxy-19-norpregn-4-ene-3,20-dione; 17α-Deacetylnestorone
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C21H28O3
Molar mass 328.445 g/mol
3D model (JSmol)

Segesterone (INN, USAN),[1][2] also known as 17α-hydroxy-16-methylene-19-norprogesterone or as 17α-deacetylnestorone, is a steroidal progestin of the 19-norprogesterone group that was never marketed.[3] An acetate ester, segesterone acetate, better known as nestorone or elcometrine, is marketed for clinical use.[4] Segesterone acetate produces segesterone as a metabolite.[5]

References[edit]

  1. ^ http://www.who.int/medicines/publications/druginformation/innlists/PL89.pdf
  2. ^ http://chem.sis.nlm.nih.gov/chemidplus/rn/7690-08-6
  3. ^ https://pubchem.ncbi.nlm.nih.gov/compound/11823650
  4. ^ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1403–. ISBN 978-1-60913-345-0. 
  5. ^ Prasad PV, Bashir M, Sitruk-Ware R, Kumar N (2010). "Single-dose pharmacokinetics of Nestorone, a potential female-contraceptive". Steroids. 75 (3): 252–64. doi:10.1016/j.steroids.2009.12.011. PMID 20064539.