In the Roman foundation myth, a she-wolf was an Italian wolf who nursed and sheltered the twins Romulus and Remus after they were abandoned in the wild by decree of King Amulius of Alba Longa. She cared for the infants at her den, a cave known as the Lupercal, until they were discovered by a shepherd, Faustulus. Romulus would later become the founder and first king of Rome. The image of the she-wolf suckling the twins has been a symbol of Rome since ancient times and is one of the most recognizable icons of ancient mythology.

The founding of Rome was a prehistoric event or process later greatly embellished by Roman historians and poets. Archaeological evidence indicates that Rome developed from the gradual union of several hilltop villages during the Final Bronze Age or early Iron Age. Prehistoric habitation of the Italian Peninsula occurred by 48,000 years ago, with the area of Rome being settled by around 1600 BC. Some evidence on the Capitoline Hill possibly dates as early as c. 1700 BC and the nearby valley that later housed the Roman Forum had a developed necropolis by at least 1000 BC. The combination of the hilltop settlements into a single polity by the later 8th century BC was probably influenced by the trend for city-state formation emerging from ancient Greece.