The siege of Pemaquid was a successful attack by a large band of Abenaki Indians on the English fort at Pemaquid, Fort Charles, then the easternmost outpost of colonial Massachusetts. The French-Abenaki attack was led by Jean-Vincent d'Abbadie de Saint-Castin and Father Louis-Pierre Thury and Chief Moxus. The fall of Pemaquid was a significant setback to the English. It pushed the frontier back to Casco (Falmouth), Maine.

John Gyles was an interpreter and soldier, most known for his account of his experiences with the Maliseet tribes at their headquarters at Meductic, on the Saint John River.