Silandrone

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Silandrone
Silandrone.png
Clinical data
Synonyms Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
Routes of
administration
By mouth, intramuscular injection, subcutaneous injection
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.023.414 Edit this at Wikidata
Chemical and physical data
Formula C22H36O2Si
Molar mass 360.613 g/mol
3D model (JSmol)

Silandrone (INN, USAN) (developmental code names SC-16148, NSC-95147), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.[1] It has a very long duration of action when given via subcutaneous or intramuscular injection as well as, notably, significantly greater potency than that of testosterone propionate.[2][3] In addition, it is notable that silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.[4]

See also[edit]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–. ISBN 978-1-4757-2085-3. 
  2. ^ Saunders FJ (November 1966). "A singularly long-acting ether of testosterone". Proc. Soc. Exp. Biol. Med. 123 (2): 303–4. doi:10.3181/00379727-123-31472. PMID 5951069. 
  3. ^ Le Boeuf BJ, Allen JL (1970). "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148". Hormones and Behavior. 1 (2). doi:10.1016/0018-506X(70)90004-8. 
  4. ^ Leland J. Chinn (1969). The Chemistry and Biochemistry of Steroids. Geron-X. p. 97.