South of the Border is an attraction on Interstate 95 (I-95), US Highway 301 (US 301) and US 501 in Hamer, South Carolina, United States, just south of Rowland, North Carolina. It is so named because it is just south of the border between North Carolina and South Carolina, and was the halfway point to Florida from New York in the early days of motor travel. The area is themed in faux-Mexican style, alluding to Mexico's location south of its border with the United States. The rest area contains restaurants, gas stations, a video arcade, motel, truck stop, a small amusement park, a mini golf course, shopping, fireworks stores, and a motocross training complex. Its mascot is Pedro, a caricature of a Mexican bandido. South of the Border is known for its roadside billboard advertisements, which begin many miles away from and incorporate a mileage countdown to the attraction itself.

Interstate 95 (I-95) is a major Interstate Highway, running along the East Coast of the United States from Florida to Maine. In South Carolina, I-95 runs approximately parallel to the Atlantic Ocean shore although about 50 miles (80 km) inland, from Hardeeville in the south to Dillon in the northeast. The route runs through the cities of Florence and Walterboro.