St. Anthony's Catholic Church is a parish church in the Diocese of Davenport. The parish complex is located in downtown Davenport, Iowa, United States, at the corner of Fourth and Main Streets. It is the first church congregation organized in the city of Davenport and the second Catholic congregation, after St. Raphael's in Dubuque, in the state of Iowa. The parish buildings were listed on the National Register of Historic Places as St. Anthony's Roman Catholic Church Complex in 1984. The designation includes the church and the former school building, which is the parish's original church building and the oldest standing church building in Iowa. The designation also included the rectory, which was partially torn down in 2009. The complex was also listed on the Davenport Register of Historic Properties in 1992 as St. Anthony's Church Square. The property has been known historically as Church Square. In 2020 the parish buildings, except for the parish center, were included as contributing properties in the Davenport Downtown Commercial Historic District. Because of its recent construction date, the parish center is excluded as a contributing property.

The Diocese of Davenport is a Latin Church ecclesiastical jurisdiction, or diocese, of the Catholic Church for the southeastern quarter of the state of Iowa in the United States.