St. Mary's County, established in 1637, is a county located in the U.S. state of Maryland. As of the 2020 census, the population was 113,777. Its county seat is Leonardtown. The name is in honor of Mary, the mother of Jesus. St. Mary's County comprises the California-Lexington Park, Maryland Metropolitan Statistical Area, which also is included in the Washington-Baltimore-Arlington, DC-MD-VA-WV-PA Combined Statistical Area. It is part of the Southern Maryland region. The county was the home to the first Maryland Colony, and the first capital of the Colony of Maryland. Settled by English Catholics, it is considered to be the birthplace of religious freedom in North America, at a time when the British colonies were settled primarily by Protestants. The county is home to the Patuxent River Naval Air Station and St. Mary's College of Maryland. Traditionally, St. Mary's County has been known for its unique and historic culture of Chesapeake Bay tidewater farming, fishing, and crabbing communities. But with the advent of the military bases, growth of an extensive defense contractor presence, and the growth of St. Mary's College of Maryland, as well as increasing numbers of long-distance Washington, D.C. commuters, it has been undergoing a decades-long transformation which has seen the county's population double since 1970.

In the United States, a county or county equivalent is an administrative or political subdivision of a U.S. state or other territories of the United States which consists of a geographic area with specific boundaries and usually some level of governmental authority. The term "county" is used in 48 states, while Louisiana and Alaska have functionally equivalent subdivisions called parishes and boroughs, respectively. The specific governmental powers of counties vary widely between the states, with many providing some level of services to civil townships, municipalities, and unincorporated areas. Certain municipalities are in multiple counties; New York City is uniquely partitioned into five counties, referred to at the city government level as boroughs. Some municipalities have been consolidated with their county government to form consolidated city-counties, or have been legally separated from counties altogether to form independent cities. Conversely, those counties in Connecticut, Rhode Island, eight of Massachusetts's 14 counties, and Alaska's Unorganized Borough have no government power, existing only as geographic distinctions.