St Mary's Church is an Anglican parish church in Nantwich, Cheshire, England. The church is recorded in the National Heritage List for England as a designated Grade I listed building. It has been called the "Cathedral of South Cheshire" and it is considered by some to be one of the finest medieval churches, not only in Cheshire, but in the whole of England. The architectural writer Raymond Richards described it as "one of the great architectural treasures of Cheshire", and Alec Clifton-Taylor included it in his list of "outstanding" English parish churches.

Nantwich is a market town and civil parish in the unitary authority of Cheshire East in Cheshire, England. It has among the highest concentrations of listed buildings in England, with notably good examples of Tudor and Georgian architecture. It had a population of 14,045 in 2021.