The Church of Saint Nicholas of Myra, usually known as St. Nicholas Church, is an Anglican church in Brighton, England. It is both the original parish church of Brighton and, after St Helen's Church, Hangleton and St Peter's Church in Preston village, the third oldest surviving building in the city of Brighton and Hove. It is located on high ground at the junction of Church Street and Dyke Road in the city centre, very close to the main shopping areas. Due to its architectural significance the church is a Grade II* listed building.

Brighton is a seaside resort and one of the two main areas of the city of Brighton and Hove in the county of East Sussex, England. It is located 47 miles (76 km) south of London. Archaeological evidence of settlement in the area dates back to the Bronze Age, Roman and Anglo-Saxon periods. The ancient settlement of "Brighthelmstone" was documented in the Domesday Book (1086). The town's importance grew in the Middle Ages as the Old Town developed, but it languished in the early modern period, affected by foreign attacks, storms, a suffering economy and a declining population. Brighton began to attract more visitors following improved road transport to London and becoming a boarding point for boats travelling to France. The town also developed in popularity as a health resort for sea bathing as a purported cure for illnesses.