1.
Ultrasound
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Ultrasound is sound waves with frequencies higher than the upper audible limit of human hearing. Ultrasound is no different from normal sound in its physical properties and this limit varies from person to person and is approximately 20 kilohertz in healthy, young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz, Ultrasound is used in many different fields. Ultrasonic devices are used to detect objects and measure distances, Ultrasound imaging or sonography is often used in medicine. In the nondestructive testing of products and structures, ultrasound is used to detect invisible flaws, industrially, ultrasound is used for cleaning, mixing, and to accelerate chemical processes. Animals such as bats and porpoises use ultrasound for locating prey, scientist are also studying ultrasound using graphene diaphragms as a method of communication. Acoustics, the science of sound, starts as far back as Pythagoras in the 6th century BC, echolocation in bats was discovered by Lazzaro Spallanzani in 1794, when he demonstrated that bats hunted and navigated by inaudible sound and not vision. The first technological application of ultrasound was an attempt to detect submarines by Paul Langevin in 1917, the piezoelectric effect, discovered by Jacques and Pierre Curie in 1880, was useful in transducers to generate and detect ultrasonic waves in air and water. Ultrasound is defined by the American National Standards Institute as sound at frequencies greater than 20 kHz, in air at atmospheric pressure ultrasonic waves have wavelengths of 1.9 cm or less. The upper frequency limit in humans is due to limitations of the middle ear, auditory sensation can occur if high‐intensity ultrasound is fed directly into the human skull and reaches the cochlea through bone conduction, without passing through the middle ear. Children can hear some high-pitched sounds that older adults cannot hear, the Mosquito is an electronic device that uses a high pitched frequency to deter loitering by young people. Bats use a variety of ultrasonic ranging techniques to detect their prey and they can detect frequencies beyond 100 kHz, possibly up to 200 kHz. Many insects have good hearing and most of these are nocturnal insects listening for echolocating bats. This includes many groups of moths, beetles, praying mantids, upon hearing a bat, some insects will make evasive manoeuvres to escape being caught. Ultrasonic frequencies trigger an action in the noctuid moth that cause it to drop slightly in its flight to evade attack. Tiger moths also emit clicks which may disturb bats echolocation, dogs and cats hearing range extends into the ultrasound, the top end of a dogs hearing range is about 45 kHz, while a cats is 64 kHz. The wild ancestors of cats and dogs evolved this higher hearing range to hear sounds made by their preferred prey. A dog whistle is a whistle that emits ultrasound, used for training and calling dogs, porpoises have the highest known upper hearing limit, at around 160 kHz
2.
Obstetrics
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Obstetrics is the field of study concentrated on pregnancy, childbirth, and the postpartum period. As a medical specialty, obstetrics is combined with gynaecology under the discipline known as obstetrics, prenatal care is important in screening for various complications of pregnancy. The newer integrated screen can be done at 10 plus weeks to 13 plus weeks with an ultrasound of the fetal neck and it gives an accurate risk profile very early. A second blood screen at 15 to 20 weeks refines the risk more accurately, the cost is higher than an AFP-quad screen due to the ultrasound and second blood test, but it is quoted to have a 93% pick up rate as opposed to 88% for the standard AFP/QS. This is a standard of care in the United States. If positive, the woman receives IV penicillin or ampicillin while in labor—or, if she is allergic to penicillin, glucose loading test - screens for gestational diabetes, if >140 mg/dL, a glucose tolerance test is administered, a fasting glucose >105 mg/dL suggests gestational diabetes. Specialised ultrasound equipment can also evaluate the flow velocity in the umbilical cord. X-rays and computerized tomography are not used, especially in the first trimester, due to the ionizing radiation, no effects of magnetic resonance imaging on the foetus have been demonstrated, but this technique is too expensive for routine observation. Instead, obstetric ultrasonography is the method of choice in the first trimester and throughout the pregnancy, because it emits no radiation, is portable. The safety of frequent ultrasound scanning has not be confirmed, despite this, increasing numbers of women are choosing to have additional scans for no medical purpose, such as gender scans, 3D and 4D scans. A normal gestation would reveal a gestational sac, yolk sac, the gestational age can be assessed by evaluating the mean gestational sac diameter before week 6, and the crown-rump length after week 6. Multiple gestation is evaluated by the number of placentae and amniotic sacs present, other tools used for assessment include, Fetal screening is used to help assess the viability of the fetus, as well as congenital abnormalities. Fetal karyotype can be used for the screening of genetic diseases, Fetal lung maturity is associated with how much surfactant the fetus is producing. Reduced production of surfactant indicates decreased lung maturity and is a risk factor for infant respiratory distress syndrome. Typically a lecithin, sphingomyelin ratio greater than 1.5 is associated with increased lung maturity, diabetes mellitus and pregnancy deals with the interactions of diabetes mellitus and pregnancy. Risks for the child include miscarriage, growth restriction, growth acceleration, feotal obesity, polyhydramnios, systemic lupus erythematosus and pregnancy confers an increased rate of foetal death in utero and spontaneous abortion, as well as of neonatal lupus. Thyroid disease in pregnancy can, if uncorrected, cause adverse effects on foetal and maternal well-being, the deleterious effects of thyroid dysfunction can also extend beyond pregnancy and delivery to affect neurointellectual development in the early life of the child. Demand for thyroid hormones is increased during pregnancy, and may cause a previously unnoticed thyroid disorder to worsen, hypercoagulability in pregnancy is the propensity of pregnant women to develop thrombosis
3.
Fetal
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A fetus is a stage in the prenatal development of viviparous organisms. In human development, a fetus or foetus is a human between the embryonic state and birth. The fetal stage of development tends to be taken as beginning at the age of eleven weeks. In biological terms, however, prenatal development is a continuum, the use of the term fetus generally implies that an embryo has developed to the point of being recognizable as a human, this is the point usually taken to be the ninth week after fertilization. A fetus is also characterized by the presence of all the body organs, though they will not yet be fully developed and functional. The word fetus is from the Latin fētus, the British, Irish, and Commonwealth spelling is foetus, which has been in use since at least 1594. It arose as a hypercorrection based on an incorrect etymology that may have originated with an error by Isidore of Seville in AD620 and this spelling is the most common in most Commonwealth nations, except in the medical literature, where fetus is used. The etymologically accurate original spelling fetus is used in Canada and the United States, in addition, fetus is now the standard English spelling throughout the world in medical journals. The spelling faetus was used historically, in humans, the fetal stage commences at the beginning of the ninth week. At the start of the stage, the fetus is typically about 30 millimetres in length from crown to rump. The head makes up half of the fetus size. Breathing-like movement of the fetus is necessary for stimulation of lung development, the heart, hands, feet, brain and other organs are present, but are only at the beginning of development and have minimal operation. The genitalia of the starts to form and placenta becomes fully functional during week 9. At this point in development, uncontrolled movements and twitches occur as muscles, the brain, and pathways begin to develop. A woman pregnant for the first time, typically feels fetal movements at about 21 weeks, whereas a woman who has given birth at least once, by the end of the fifth month, the fetus is about 20 cm long. The amount of body fat rapidly increases, thalamic brain connections, which mediate sensory input, form. Bones are fully developed, but are soft and pliable. Iron, calcium, and phosphorus become more abundant, fingernails reach the end of the fingertips
4.
Diagnostic method
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Medical diagnosis is the process of determining which disease or condition explains a persons symptoms and signs. It is most often referred to as diagnosis with the context being implicit. The information required for diagnosis is typically collected from a history, often, one or more diagnostic procedures, such as diagnostic tests, are also done during the process. Sometimes Posthumous diagnosis is considered a kind of medical diagnosis, Diagnosis is often challenging, because many signs and symptoms are nonspecific. For example, redness of the skin, by itself, is a sign of many disorders, thus differential diagnosis, in which several possible explanations are compared and contrasted, must be performed. This involves the correlation of various pieces of information followed by the recognition and differentiation of patterns, occasionally the process is made easy by a sign or symptom that is pathognomonic. Diagnosis is a component of the procedure of a doctors visit. From the point of view of statistics, the procedure involves classification tests. The first recorded examples of medical diagnosis are found in the writings of Imhotep in ancient Egypt, a Babylonian medical textbook, the Diagnostic Handbook written by Esagil-kin-apli, introduced the use of empiricism, logic and rationality in the diagnosis of an illness or disease. Traditional Chinese Medicine, as described in the Yellow Emperors Inner Canon or Huangdi Neijing, specified four diagnostic methods, inspection, auscultation-olfaction, interrogation, hippocrates was known to make diagnoses by tasting his patients urine and smelling their sweat. This article uses diagnostician as any of these person categories, a diagnostic procedure does not necessarily involve elucidation of the etiology of the diseases or conditions of interest, that is, what caused the disease or condition. Such elucidation can be useful to optimize treatment, further specify the prognosis or prevent recurrence of the disease or condition in the future, the initial task is to detect a medical indication to perform a diagnostic procedure. Indications include, Detection of any deviation from what is known to be normal, such as can be described in terms of, for example, anatomy, physiology, pathology, psychology, a complaint expressed by a patient. The fact that a patient has sought a diagnostician can itself be an indication to perform a diagnostic procedure, even during an already ongoing diagnostic procedure, there can be an indication to perform another, separate, diagnostic procedure for another, potentially concomitant, disease or condition. A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease, Diagnostic tests can also be used to provide prognostic information on people with established disease. Processing of the answers, findings or other results, consultations with other providers and specialists in the field may be sought. There are a number of methods or techniques that can be used in a diagnostic procedure, in reality, a diagnostic procedure may involve components of multiple methods. The final result may also remain a list of possible conditions, the resultant diagnostic opinion by this method can be regarded more or less as a diagnosis of exclusion
5.
Vital signs
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Vital signs are a group of the 4 to 6 most important signs that indicate the status of the body’s vital functions. These measurements are taken to assess the general physical health of a person, give clues to possible diseases. The normal ranges for a person’s vital signs vary with age, weight, gender, there are four primary vital signs, body temperature, blood pressure, pulse, and breathing rate, often notated as BT, BP, HR, and RR. However, depending on the setting, the vital signs may include other measurements called the fifth vital sign or sixth vital sign. Vital signs are recorded using the LOINC internationally accepted standard coding system, early warning scores have been proposed that combine the individual values of vital signs into a single score. This was done in recognition that deteriorating vital signs often precede cardiac arrest and/or admission to the intensive care unit, used appropriately, a rapid response team can assess and treat a deteriorating patient and prevent adverse outcomes. Though a pulse can be taken by hand, a stethoscope may be required for a patient with a weak pulse. Temperature recording gives an indication of core body temperature which is tightly controlled as it affects the rate of chemical reactions. Temperature can be recorded in order to establish a baseline for the normal body temperature for the site. Other causes of elevated temperature include hyperthermia, temperature depression also needs to be evaluated. It is also noteworthy to review the trend of the patients temperature, a patient with a fever of 38 °C does not necessarily indicate an ominous sign if his previous temperature has been higher. Body temperature is maintained through a balance of the produced by the body. Temperature is commonly considered to be a vital sign most notably in a hospital setting, eMTs, in particular, are taught to measure the vital signs of, respiration, pulse, skin, pupils, and blood pressure as the 5 vital signs in a non-hospital setting. The pulse or heart rate is the rate at which the beats while pumping blood through the arteries. Its rate is measured either at the wrist or the ankle and is recorded as beats per minute. The pulse commonly taken is from the artery at the wrist. Sometimes the pulse cannot be taken at the wrist and is taken at the elbow, at the neck against the artery, behind the knee. The pulse rate can also be measured by listening directly to the using a stethoscope
6.
Guilt (emotion)
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It is closely related to the concept of remorse. Guilt is an important factor in perpetuating obsessive–compulsive disorder symptoms, Guilt and its associated causes, merits, and demerits are common themes in psychology and psychiatry. Both in specialized and in language, guilt is an affective state in which one experiences conflict at having done something that one believes one should not have done. It gives rise to a feeling which does not go away easily, sigmund Freud described this as the result of a struggle between the ego and the superego – parental imprinting. Freud rejected the role of God as punisher in times of illness or rewarder in time of wellness, while removing one source of guilt from patients, he described another. For his later explicator, Lacan, guilt was the companion of the signifying subject who acknowledged normality in the form of the Symbolic order. This may be linked to what Les Parrott has called the disease of false guilt. At the root of false guilt is the idea that what you feel must be true, if you feel guilty, you must be guilty. The philosopher Martin Buber underlined the difference between the Freudian notion of guilt, based on conflicts, and existential guilt, based on actual harm done to others. Guilt is often associated with anxiety, in mania, according to Otto Fenichel, the patient succeeds in applying to guilt the defense mechanism of denial by overcompensation. re-enacts being a person without guilt feelings. In psychological research, guilt can be measured by using questionnaires, such as the Differential Emotions Scale, defenses against feeling guilt can become an overriding aspect of ones personality. The methods that can be used to avoid guilt are multiple and they include, Repression, usually used by the superego and ego against instinctive impulses, but on occasion employed against the superego/conscience itself. If the defence fails, then one may begin to feel guilty years later for actions lightly committed at the time, projection is another defensive tool with wide applications. Alternatively, not the guilt, but the agency itself, may be projected onto other people. Feelings of guilt can prompt subsequent virtuous behavior, people who feel guilty may be more likely to exercise restraint, avoid self-indulgence, and exhibit less prejudice. Guilt appears to prompt reparatory behaviors to alleviate the negative emotions that it engenders, people appear to engage in targeted and specific reparatory behaviors toward the persons they wronged or offended. Individuals high in psychopathy lack any sense of guilt or remorse for harm they may have caused others. Instead, they rationalize their behavior, blame someone else, or deny it outright, a person with psychopathy has a tendency to be harmful to his or herself and to others. They have little ability to plan ahead for the future, an individual with psychopathy will never find themselves at fault because they will do whatever it takes to benefit themselves without reservation
7.
Placenta
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The placenta provides oxygen and nutrients to growing babies and removes waste products from the babys blood. The placenta attaches to the wall of the uterus, and the umbilical cord develops from the placenta. The umbilical cord is what connects the mother and the baby, Placentas are a defining characteristic of placental mammals, but are also found in some non-mammals with varying levels of development. The homology of structures in various viviparous organisms is debatable. The classical plural is placentae, but the form placentas is common in modern English, prototherial and metatherial mammals produce a choriovitelline placenta that, while connected to the uterine wall, provides nutrients mainly derived from the egg sac. In humans, the placenta averages 22 cm in length and 2–2.5 cm in thickness, with the center being the thickest, and it typically weighs approximately 500 grams. It has a dark reddish-blue or crimson color and it connects to the fetus by an umbilical cord of approximately 55–60 cm in length, which contains two umbilical arteries and one umbilical vein. The umbilical cord inserts into the chorionic plate, vessels branch out over the surface of the placenta and further divide to form a network covered by a thin layer of cells. This results in the formation of villous tree structures, on the maternal side, these villous tree structures are grouped into lobules called cotyledons. In humans, the placenta usually has a shape. The placental flora more closely resembles that of the oral microbiome than either the vaginal or rectal microbiome, in non-human animals, part of the microbiome is passed onto offspring even before the offspring are born. Bacteriologists assume that the same holds true for humans. The placenta begins to develop upon implantation of the blastocyst into the maternal endometrium, the outer layer of the blastocyst becomes the trophoblast, which forms the outer layer of the placenta. This outer layer is divided into two layers, the underlying cytotrophoblast layer and the overlying syncytiotrophoblast layer. The syncytiotrophoblast is a continuous cell layer that covers the surface of the placenta. It forms as a result of differentiation and fusion of the underlying cytotrophoblast cells, the syncytiotrophoblast, thereby contributes to the barrier function of the placenta. Development of the blood supply to the placenta is complete by the end of the first trimester of pregnancy. In preparation for implantation of the blastocyst, the uterine endometrium undergoes decidualisation, spiral arteries in decidua are remodeled so that they become less convoluted and their diameter is increased
8.
Umbilical cord
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In placental mammals, the umbilical cord is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the cord is physiologically and genetically part of the fetus and. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta, conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta. The umbilical cord develops from and contains remnants of the yolk sac and it forms by the fifth week of fetal development, replacing the yolk sac as the source of nutrients for the fetus. The cord is not directly connected to the circulatory system, but instead joins the placenta. The length of the cord is approximately equal to the crown-rump length of the fetus throughout pregnancy. The umbilical cord in a full term neonate is usually about 50 centimeters long and this diameter decreases rapidly within the placenta. The smooth muscle cells of the layer are rather poorly differentiated, the umbilical cord contains Whartons jelly, a gelatinous substance made largely from mucopolysaccharides which protects the blood vessels inside. It contains one vein, which carries oxygenated, nutrient-rich blood to the fetus, occasionally, only two vessels are present in the umbilical cord. This is sometimes related to fetal abnormalities, but it may occur without accompanying problems. It is unusual for a vein to carry oxygenated blood and for arteries to carry deoxygenated blood, however, this naming convention reflects the fact that the umbilical vein carries blood towards the fetuss heart, while the umbilical arteries carry blood away. The blood flow through the cord is approximately 35 ml / min at 20 weeks. Adapted to the weight of the fetus, this corresponds to 115 ml / min / kg at 20 weeks and 64 ml / min / kg at 40 weeks, the umbilical cord enters the fetus via the abdomen, at the point which will become the umbilicus. Within the fetus, the umbilical vein continues towards the transverse fissure of the liver, one of these branches joins with the hepatic portal vein, which carries blood into the liver. The second branch bypasses the liver and flows into the vena cava. The two umbilical arteries branch from the iliac arteries, and pass on either side of the urinary bladder into the umbilical cord. In effect, a clamp is created, halting the flow of blood. In air at 18 °C, this physiological clamping will take three minutes or less, in water birth, where the water temperature is close to body temperature, normal pulsation can be 5 minutes and longer
9.
Developing world
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Also, the general term less-developed country should not be confused with the specific least developed country. The term developing describes a currently observed situation and not a dynamic or expected direction of progress, since the late 1990s developing countries tended to demonstrate higher growth rates than the developed ones. There is criticism of the use of the developing country. The term implies inferiority of a country or undeveloped country compared with a developed country. It assumes a desire to develop along the traditional Western model of development which a few countries, such as Cuba and Bhutan. An alternative measurement that has suggested is that of gross national happiness. Countries on the boundary between developed and developing are often categorized under the newly industrialized countries. In the 2016 edition of its World Development Indicators, the World Bank made a decision to no longer distinguish between “developed” and “developing” countries in the presentation of its data, nobody has ever agreed on a definition for these terms in the first place. Various terms are used for whatever is not a developed country, terms used include less developed country or less economically developed country, and for the more extreme, least developed country or least economically developed country. But according to the United Nations Statistics Division, There is no established convention for the designation of developed, the World Bank classifies countries into four income groups. These are set each year on July 1, economies were divided according to 2016 GNI per capita using the following ranges of income, Low income countries had GNI per capita of US$1,025 or less. Lower middle income countries had GNI per capita between US$1,026 and US$4,035, upper middle income countries had GNI per capita between US$4,036 and US$12,475. High income countries had GNI per capita above US$12,476 and this may be by absolute numbers or country ranking. The UN has developed the Human Development Index, an indicator of the above statistics. The UN sets Millennium Development Goals from a blueprint developed by all of the countries and leading development institutions. There is an association between low income and high population growth. The terms utilized when discussing developing countries refer to the intent, other terms sometimes used are less developed countries, least economically developed countries, underdeveloped nations or Third World nations, and non-industrialized nations. Conversely, developed countries, most economically developed countries, First World nations and that is, LEDCs are the poorest subset of LDCs
10.
Developed world
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Which criteria are to be used and which countries can be classified as being developed are subjects of debate. Developed countries have post-industrial economies, meaning the sector provides more wealth than the industrial sector. They are contrasted with developing countries, which are in the process of industrialization, or undeveloped countries, which are pre-industrial and almost entirely agrarian. As of 2015, advanced economies comprise 60. 8% of global GDP based on values and 42. 9% of global GDP based on purchasing-power parity according to the International Monetary Fund. In 2015, the ten largest advanced economies by GDP in both nominal and PPP terms were Australia, Canada, France, Germany, Italy, Japan, South Korea, Spain, the United Kingdom, and the United States. The term industrialized country may be ambiguous, as industrialization is an ongoing process that is hard to define. The first industrialized country was the United Kingdom, followed by Belgium, later it spread further to Germany, United States, France and other Western European countries. According to some such as Jeffrey Sachs, however, the current divide between the developed and developing world is largely a phenomenon of the 20th century. Economic criteria have tended to dominate discussions, one such criterion is income per capita, countries with high gross domestic product per capita would thus be described as developed countries. Another economic criterion is industrialization, countries in which the tertiary and quaternary sectors of industry dominate would thus be described as developed. More recently another measure, the Human Development Index, which combines an economic measure, national income, with other measures, indices for life expectancy and this criterion would define developed countries as those with a very high rating. According to the United Nations Statistics Division, There is no established convention for the designation of developed, the UN HDI is a statistical measure that gauges a countrys level of human development. While there is a correlation between having a high HDI score and a prosperous economy, the UN points out that the HDI accounts for more than income or productivity. Unlike GDP per capita or per capita income, the HDI takes into account how income is turned into education and health opportunities, since 1990, Norway, Japan, Canada and Iceland have had the highest HDI score. The top 47 countries have scores ranging from 0.793 in Barbados to 0.955 in Norway, many countries listed by IMF or CIA as advanced, possess an HDI over 0.788. Many countries possessing an HDI of 0.788 and over are also listed by IMF or CIA as advanced, thus, many advanced economies are characterized by an HDI score of 0.9 or higher. Since April 2016, the IMF classifies Macau as an advanced economy, the latest index was released on 14 December 2015 and covers the period up to 2014. The following are the 49 countries in the top quartile - having an HDI above 0.8, = Increase = No increase or decrease = Decrease The number in parentheses represents the number of ranks the country has climbed relative to the ranking in 2014 report
11.
South Asia
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Topographically, it is dominated by the Indian Plate, which rises above sea level as Nepal and northern parts of India situated south of the Himalayas and the Hindu Kush. South Asia is bounded on the south by the Indian Ocean and on land by West Asia, Central Asia, East Asia, the current territories of Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan, and Sri Lanka form the countries of South Asia. The South Asian Association for Regional Cooperation is an economic cooperation organisation in the region which was established in 1985, South Asia covers about 5.1 million km², which is 11. 51% of the Asian continent or 3. 4% of the worlds land surface area. The population of South Asia is about 1.749 billion or about one fourth of the worlds population, overall, it accounts for about 39. 49% of Asias population and is home to a vast array of peoples. The area of South Asia and its extent is not clear cut as systemic. Aside from the region of South Asia, formerly part of the British Empire, there is a high degree of variation as to which other countries are included in South Asia. Modern definitions of South Asia are consistent in including Afghanistan, India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, Myanmar is included by some scholars in South Asia, but in Southeast Asia by others. Some do not include Afghanistan, others question whether Afghanistan should be considered a part of South Asia or the Middle East, the mountain countries of Nepal and Bhutan, and the island countries of Sri Lanka and Maldives are generally included as well. Myanmar is often added, and by various deviating definitions based on often substantially different reasons, the British Indian Ocean Territory, the common concept of South Asia is largely inherited from the administrative boundaries of the British Raj, with several exceptions. The Aden Colony, British Somaliland and Singapore, though administered at various times under the Raj, have not been proposed as any part of South Asia. Additionally Burma was administered as part of the Raj until 1937, the 562 princely states that were protected by but not directly ruled by the Raj became administrative parts of South Asia upon joining Union of India or Dominion of Pakistan. China and Myanmar have also applied for the status of members of SAARC. This bloc of countries include two independent countries that were not part of the British Raj – Nepal, and Bhutan, Afghanistan was a British protectorate from 1878 until 1919, after the Afghans lost to the British in the Second Anglo-Afghan war. The United Nations Statistics Divisions scheme of sub-regions include all eight members of the SAARC as part of Southern Asia, population Information Network includes Afghanistan, Bangladesh, Burma, India, Nepal, Pakistan and Sri Lanka as part of South Asia. Maldives, in view of its characteristics, was admitted as a member Pacific POPIN subregional network only in principle, the Hirschman–Herfindahl index of the United Nations Economic and Social Commission for Asia and the Pacific for the region includes only the original seven signatories of SAARC. The British Indian Ocean Territory is connected to the region by a publication of Janes for security considerations, the inclusion of Myanmar in South Asia is without consensus, with many considering it a part of southeast Asia and others including it within South Asia. Afghanistan was of importance to the British colonial empire, especially after the Second Anglo-Afghan War over 1878–1880, Afghanistan remained a British protectorate until 1919, when a treaty with Vladimir Lenin included the granting of independence to Afghanistan. Following Indias partition, Afghanistan has generally included in South Asia
12.
Sub-Saharan Africa
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Sub-Saharan Africa is, geographically, the area of the continent of Africa that lies south of the Sahara. According to the UN, it consists of all African countries that are fully or partially located south of the Sahara and it contrasts with North Africa, whose territories are part of the League of Arab states within the Arab world. Somalia, Djibouti, Comoros and Mauritania are geographically in Sub-Saharan Africa, the Sahel is the transitional zone between the Sahara and the tropical savanna and forest-savanna mosaic to the south. The Sahara pump theory explains how flora and fauna left Africa to penetrate the Middle East, African pluvial periods are associated with a wet Sahara phase during which larger lakes and more rivers existed. Geographers historically divided the region into several distinct ethnographic sections based on each areas respective inhabitants, commentators in Arabic in the medieval period used the general term bilâd as-sûdân for the vast Sudan region, or sometimes extending from the coast of West Africa to Western Sudan. Its equivalent in Southeast Africa was Zanj, which was situated in the vicinity of the Great Lakes region. The geographers drew an explicit distinction between the Sudan region and its analogue Zanj, from the area to their extreme east on the Red Sea coast in the Horn of Africa. In modern-day Ethiopia and Eritrea was Al-Habash or Abyssinia, which was inhabited by the Habash or Abyssinians, Sub-Saharan Africa has a wide variety of climate zones or biomes. South Africa and the Democratic Republic of the Congo in particular are considered Megadiverse countries, the Sahel shoots across all of Africa at a latitude of about 10° to 15° N. Countries that include parts of the Sahara Desert proper in their territories and parts of the Sahel in their southern region include Mauritania, Mali, Niger, Chad. The Sahel has a hot semi-arid climate, South of the Sahel, there is a belt of savanna, widening to include most of South Sudan and Ethiopia in the east. The Serengeti ecosystem is located in northwestern Tanzania and extends to southwestern Kenya, the Kalahari Basin includes the Kalahari Desert surrounded by a belt of semi-desert. The Bushveld is a tropical ecoregion of Southern Africa. The Karoo is a semi-desert in western South Africa and this occurred 10 million to 5 million years ago. By 3 million years ago several australopithecine hominid species had developed throughout southern, eastern and they were tool users rather than tool manufacturers. The tools were classed as Oldowan, roughly 1.8 million years ago, Homo ergaster first appeared in the fossil record in Africa. From Homo ergaster, Homo erectus evolved 1.5 million years ago, some of the earlier representatives of this species were small-brained and used primitive stone tools, much like H. habilis. The brain later grew in size, and H. erectus eventually developed a complex stone tool technology called the Acheulean
13.
World Health Organization
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The World Health Organization is a specialised agency of the United Nations that is concerned with international public health. It was established on 7 April 1948, headquartered in Geneva, the WHO is a member of the United Nations Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations, the constitution of the World Health Organization had been signed by 61 countries on 22 July 1946, with the first meeting of the World Health Assembly finishing on 24 July 1948. It incorporated the Office international dhygiène publique and the League of Nations Health Organization, since its creation, it has played a leading role in the eradication of smallpox. The WHO is responsible for the World Health Report, an international publication on health, the worldwide World Health Survey. The head of WHO is Margaret Chan, the 2014/2015 proposed budget of the WHO is about US$4 billion. About US$930 million are to be provided by member states with a further US$3 billion to be from voluntary contributions, after failing to get a resolution passed on the subject, Alger Hiss, the Secretary General of the conference, recommended using a declaration to establish such an organisation. Dr. Sze and other delegates lobbied and a declaration passed calling for a conference on health. The use of the world, rather than international, emphasised the truly global nature of what the organisation was seeking to achieve. The constitution of the World Health Organization was signed by all 51 countries of the United Nations and it thus became the first specialised agency of the United Nations to which every member subscribed. Its constitution formally came into force on the first World Health Day on 7 April 1948, the first meeting of the World Health Assembly finished on 24 July 1948, having secured a budget of US$5 million for the 1949 year. Andrija Stampar was the Assemblys first president, and G. Brock Chisholm was appointed Director-General of WHO and its first priorities were to control the spread of malaria, tuberculosis and sexually transmitted infections, and to improve maternal and child health, nutrition and environmental hygiene. Its first legislative act was concerning the compilation of statistics on the spread. The logo of the World Health Organization features the Rod of Asclepius as a symbol for healing, in 1947 the WHO established an epidemiological information service via telex, and by 1950 a mass tuberculosis inoculation drive using the BCG vaccine was under way. In 1955, the eradication programme was launched, although it was later altered in objective. 1965 saw the first report on diabetes mellitus and the creation of the International Agency for Research on Cancer. In 1958, Viktor Zhdanov, Deputy Minister of Health for the USSR, called on the World Health Assembly to undertake an initiative to eradicate smallpox. At this point,2 million people were dying from smallpox every year, in 1966, WHO moved into its headquarters building
14.
Chromosome
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A chromosome is a DNA molecule with part or all of the genetic material of an organism. Prokaryotes usually have one single circular chromosome, whereas most eukaryotes are diploid, chromosomes in eukaryotes are composed of chromatin fiber. Chromatin fiber is made of nucleosomes, a nucleosome is a histone octamer with part of a longer DNA strand attached to and wrapped around it. Chromatin fiber, together with associated proteins is known as chromatin, chromatin is present in most cells, with a few exceptions, for example, red blood cells. Occurring only in the nucleus of cells, chromatin contains the vast majority of DNA, except for a small amount inherited maternally. Chromosomes are normally visible under a microscope only when the cell is undergoing the metaphase of cell division. Before this happens every chromosome is copied once, and the copy is joined to the original by a centromere resulting in an X-shaped structure, the original chromosome and the copy are now called sister chromatids. During metaphase, when a chromosome is in its most condensed state, in this highly condensed form chromosomes are easiest to distinguish and study. In prokaryotic cells, chromatin occurs free-floating in cytoplasm, as these cells lack organelles, the main information-carrying macromolecule is a single piece of coiled double-helix DNA, containing many genes, regulatory elements and other noncoding DNA. The DNA-bound macromolecules are proteins that serve to package the DNA, chromosomes vary widely between different organisms. Some species such as certain bacteria also contain plasmids or other extrachromosomal DNA and these are circular structures in the cytoplasm that contain cellular DNA and play a role in horizontal gene transfer. Chromosomal recombination during meiosis and subsequent sexual reproduction plays a significant role in genetic diversity. In prokaryotes and viruses, the DNA is often densely packed and organized, in the case of archaea, by homologs to eukaryotic histones, small circular genomes called plasmids are often found in bacteria and also in mitochondria and chloroplasts, reflecting their bacterial origins. Some use the term chromosome in a sense, to refer to the individualized portions of chromatin in cells. However, others use the concept in a sense, to refer to the individualized portions of chromatin during cell division. The word chromosome comes from the Greek χρῶμα and σῶμα, describing their strong staining by particular dyes, schleiden, Virchow and Bütschli were among the first scientists who recognized the structures now so familiar to everyone as chromosomes. The term was coined by von Waldeyer-Hartz, referring to the term chromatin, in a series of experiments beginning in the mid-1880s, Theodor Boveri gave the definitive demonstration that chromosomes are the vectors of heredity. His two principles were the continuity of chromosomes and the individuality of chromosomes and it is the second of these principles that was so original
15.
Fetal development
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Prenatal development is the process in which an embryo and later fetus develops during gestation. Prenatal development starts with fertilization the first stage in embryogenesis which continues in development until birth. In human pregnancy, prenatal development, also known as development, is the development of the embryo following fertilization. By the end of the week of gestational age the embryo has acquired its basic form and is referred to as a fetus. The next period is that of development where many organs become fully developed. This fetal period is described both topically and chronologically with major occurrences being listed by gestational age, in other animals the very early stages of embryogenesis are the same as those in humans. In later stages, development across all taxa of animals and the length of gestation vary, the perinatal period is around the time of birth. In developed countries and at facilities where expert neonatal care is available, in many developing countries, the starting point of this period is considered 28 completed weeks of gestation. In ICD-10, a classification list by the WHO, there is a particular chapter relating to certain conditions originating in the perinatal period. The antepartum period is equivalent to prenatal. Practically, however, antepartum usually refers to the period between the 24th/26th week of age until birth, for example in antepartum hemorrhage. When semen is released into the vagina, the travel through the cervix and body of the uterus. Fertilization of the egg cell, usually takes place in one of the Fallopian tubes, many sperm are released with the possibility of just one sperm cell managing to adhere to and enter the thick protective shell-like layer surrounding the ovum. The first sperm that penetrates fully into the egg donates its genetic material, the egg then polarizes, repelling any additional sperm. The resulting combination is called a zygote, a new and genetically unique organism, the term conception refers variably to either fertilization or to formation of the conceptus after its implantation in the uterus, and this terminology is controversial. Prior to fertilization, each ovum, as a gamete, contains half of the material that will fuse with the male gamete. The ovum only carries the X female sex chromosome whilst the sperm carries a single sex chromosome of either an X or a male Y chromosome. The resulting human zygote is similar to the majority of cells because it contains two copies of the genome in a diploid set of chromosomes
16.
Psychoactive drugs
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A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, or consciousness. These substances may be used recreationally, to alter ones consciousness, or, as entheogens, for ritual, spiritual, or shamanic purposes. Some categories of drugs, which have medical therapeutic value, are prescribed by medical doctors. There are also some psychoactive substances used in the detoxification and rehabilitation programs for drug users. Psychoactive substances often bring about changes in consciousness and mood that the user may find rewarding. In addition, sustained use of some substances may produce a physical dependence or psychological dependence syndrome associated with somatic or psychological-emotional withdrawal states respectively, Drug rehabilitation aims to break this cycle of dependency, through a combination of psychotherapy, support groups, maintenance and even other psychoactive substances. However, the reverse is true in some cases, that certain experiences on drugs may be so unfriendly. This is especially true of certain deliriants, powerful dissociatives, and classic psychedelics, in part because of this potential for substance misuse, addiction, or dependence, the ethics of drug use is debated. Restrictions on drug production and sales in an attempt to drug abuse are very common among national and sub-national governments worldwide. Ethical concerns have also raised about over-use of these drugs clinically. Psychoactive drug use can be traced to prehistory, there is archaeological evidence of the use of psychoactive substances dating back at least 10,000 years, and historical evidence of cultural use over the past 5,000 years. The chewing of coca leaves, for example, dates back over 8,000 years ago in Peruvian society, medicinal use is one important facet of psychoactive drug usage. However, some have postulated that the urge to alter ones consciousness is as primary as the drive to satiate thirst, hunger or sexual desire. Supporters of this belief contend that the history of use and even childrens desire for spinning, swinging. It is, however, necessary to precisely what is meant by the use of drugs. We do not mean the purely physical craving, but there are not many drugs which have the power of stilling such craving. This relationship is not limited to humans, a number of animals consume different psychoactive plants, animals, berries and even fermented fruit, becoming intoxicated, such as cats after consuming catnip. Traditional legends of sacred plants often contain references to animals that introduced humankind to their use, animals and psychoactive plants appear to have co-evolved, possibly explaining why these chemicals and their receptors exist within the nervous system
17.
Ethanol
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Ethanol, also called alcohol, ethyl alcohol, and drinking alcohol, is the principal type of alcohol found in alcoholic beverages. It is a volatile, flammable, colorless liquid with a characteristic odor. Its chemical formula is C 2H 6O, which can be written also as CH 3-CH 2-OH or C 2H 5-OH, ethanol is mostly produced by the fermentation of sugars by yeasts, or by petrochemical processes. It is a psychoactive drug, causing a characteristic intoxication. It is widely used as a solvent, as fuel, and as a feedstock for synthesis of other chemicals, the eth- prefix and the qualifier ethyl in ethyl alcohol originally come from the name ethyl assigned in 1834 to the group C 2H 5- by Justus Liebig. He coined the word from the German name Aether of the compound C 2H 5-O-C 2H5, according to the Oxford English Dictionary, Ethyl is a contraction of the Ancient Greek αἰθήρ and the Greek word ύλη. The name ethanol was coined as a result of a resolution that was adopted at the International Conference on Chemical Nomenclature that was held in April 1892 in Geneva, Switzerland. The term alcohol now refers to a class of substances in chemistry nomenclature. The Oxford English Dictionary claims that it is a loan from Arabic al-kuḥl, a powdered ore of antimony used since aniquity as a cosmetic. The use of alcohol for ethanol is modern, first recorded 1753, the systematic use in chemistry dates to 1850. Ethanol is used in medical wipes and most common antibacterial hand sanitizer gels as an antiseptic, ethanol kills organisms by denaturing their proteins and dissolving their lipids and is effective against most bacteria and fungi, and many viruses. However, ethanol is ineffective against bacterial spores, ethanol may be administered as an antidote to methanol and ethylene glycol poisoning. Ethanol, often in high concentrations, is used to dissolve many water-insoluble medications, as a central nervous system depressant, ethanol is one of the most commonly consumed psychoactive drugs. The amount of ethanol in the body is typically quantified by blood alcohol content, small doses of ethanol, in general, produce euphoria and relaxation, people experiencing these symptoms tend to become talkative and less inhibited, and may exhibit poor judgment. Ethanol is commonly consumed as a drug, especially while socializing. The largest single use of ethanol is as a fuel and fuel additive. Brazil in particular relies heavily upon the use of ethanol as an engine fuel, gasoline sold in Brazil contains at least 25% anhydrous ethanol. Hydrous ethanol can be used as fuel in more than 90% of new gasoline fueled cars sold in the country, Brazilian ethanol is produced from sugar cane and noted for high carbon sequestration
18.
Nicotine
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Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors, Nicotine is found in the leaves of Nicotiana rustica in amounts of 2–14%, the tobacco plant Nicotiana tabacum, Duboisia hopwoodii and Asclepias syriaca. Nicotine constitutes approximately 0. 6–3. 0% of the dry weight of tobacco, less than one millionth of that concentration is found in edible Solanaceae such as eggplants and tomatoes. It functions as a chemical, consequently, nicotine was widely used as an insecticide in the past. An average cigarette yields about 2 mg of absorbed nicotine, and in lesser doses of that order and this stimulant effect is a contributing factor to the addictive properties of tobacco smoking. Nicotines addictive nature includes psychoactive effects, drug-reinforced behavior, compulsive use, relapse after abstinence, beyond addiction, both short and long-term nicotine exposure have not been established as dangerous to adults, except among certain vulnerable groups. At high-enough doses, nicotine is associated with poisonings and is potentially lethal, Nicotine as a tool for quitting smoking has a good safety history. There is inadequate research to show that nicotine itself is associated with cancer in humans, Nicotine in the form of nicotine replacement products is less of a cancer risk than smoking. Nicotine is linked to birth defects. During pregnancy, there are risks to the later in life for type 2 diabetes, obesity, hypertension, neurobehavioral defects, respiratory dysfunction. Nicotines mood-altering effects are different by report, in particular it is both a stimulant and a relaxant, first causing a release of glucose from the liver and epinephrine from the adrenal medulla, it causes stimulation. Users report feelings of relaxation, sharpness, calmness, and alertness, like any stimulant, it may very rarely cause the often uncomfortable akathisia. By reducing the appetite and raising the metabolism, some smokers may lose weight as a consequence, Nicotine also extends the duration of positive effects of dopamine and increases the sensitivity of the brains reward system to rewarding stimuli. Most cigarettes contain 1–3 milligrams of inhalable nicotine, studies suggest that when smokers wish to achieve a stimulating effect, they take short quick puffs, which produce a low level of blood nicotine. At very high doses it dampens neuronal activity, the primary therapeutic use of nicotine is in treating nicotine dependence in order to eliminate smoking with the damage it does to health. Controlled levels of nicotine are given to patients through gums, dermal patches, lozenges, studies have found that these therapies increase the chance of success of quitting by 50 to 70%, though reductions in the population as a whole have not been demonstrated. Nicotine is frequently used for its effects on cognition, alertness. Nicotine is commonly consumed as a drug for its stimulant effects
19.
Medication
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A pharmaceutical drug is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy is an important part of the field and relies on the science of pharmacology for continual advancement. Drugs are classified in various ways, one of the key divisions is by level of control, which distinguishes prescription drugs from over-the-counter drugs. Other ways to classify medicines are by mode of action, route of administration, biological system affected, an elaborate and widely used classification system is the Anatomical Therapeutic Chemical Classification System. The World Health Organization keeps a list of essential medicines, Drug discovery and drug development are complex and expensive endeavors undertaken by pharmaceutical companies, academic scientists, and governments. Governments generally regulate what drugs can be marketed, how drugs are marketed, controversies have arisen over drug pricing and disposal of used drugs. In the US, a drug is, A substance recognized by an official pharmacopoeia or formulary, a substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease. A substance intended to affect the structure or any function of the body, a substance intended for use as a component of a medicine but not a device or a component, part or accessory of a device. Pharmaceutical or a drug is classified on the basis of their origin, Drug from natural origin, Herbal or plant or mineral origin, some drug substances are of marine origin. Drug from chemical as well as origin, Derived from partial herbal and partial chemical synthesis Chemical. Drug derived from animal origin, For example, hormones, Drug derived from microbial origin, Antibiotics Drug derived by biotechnology genetic-engineering, hybridoma technique for example Drug derived from radioactive substances. An elaborate and widely used system is the Anatomical Therapeutic Chemical Classification System. The World Health Organization keeps a list of essential medicines, the main classes of painkillers are NSAIDs, opioids and Local anesthetics. For consciousness Some anesthetics include Benzodiazepines and Barbiturates, the main categories of drugs for musculoskeletal disorders are, NSAIDs, muscle relaxants, neuromuscular drugs, and anticholinesterases. Euthanasia is not permitted by law in countries, and consequently medicines will not be licensed for this use in those countries. Administration is the process by which a patient takes a medicine, there are three major categories of drug administration, enteral, parenteral, and other. It can be performed in various forms such as pills, tablets. There are many variations in the routes of administration, including intravenous and they can be administered all at once as a bolus, at frequent intervals or continuously
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. PMID 16286486. doi:10.1136/jech.2004.023465. 
