Gerhard Johannes Paul Domagk was a German pathologist and bacteriologist. He is credited with the discovery of Sulfonamidochrysoidine, the first commercially available antibiotic and marketed under the brand name Prontosil, for which he received the 1939 Nobel Prize in Physiology or Medicine. Domagk was born in Lagow, the son of a school headmaster; until he was 14, he attended school in Sommerfeld. Domagk studied medicine at the University of Kiel, but volunteered to serve as a soldier in World War I, where he was wounded in December 1914, working the rest of the war as a medic. After the war, he finished his studies, worked at the University of Greifswald, where he researched infections caused by bacteria. In 1925, he followed his professor Walter Gross to the University of Münster and became a professor there himself, he started working at the Bayer laboratories at Wuppertal. The same year, he married Gertrud Strube, they would have three sons and a daughter. Domagk was appointed director of Bayer's Institute of Pathology and Bacteriology, where he continued the studies of Josef Klarer and Fritz Mietzsch, based on works by Paul Ehrlich, to use dyes, at that time a major product of IG Farben, as antibiotics.
He found the sulfonamide Prontosil to be effective against streptococcus, treated his own daughter with it, saving her the amputation of an arm. In 1939, Domagk received the Nobel Prize in Medicine for this discovery, the first drug effective against bacterial infections, he was forced by the Nazi regime to refuse the prize and was arrested by the Gestapo and detained for a week. In 1941 Domagk was awarded the Medaglia Paterno by the Kingdom of Italy and the Von-Klebelsberg-Medal and Prize by the Kingdom of Hungary, he became a member of the German Academy of Sciences Leopoldina in 1942. Sulfonamides had revolutionary antibacterial effectiveness for their time, surpassing phage therapy, but were replaced by penicillin, which showed both better effects and fewer side effects. However, Domagk's work on sulfonamides led to the development of the antituberculosis drugs thiosemicarbazone and isoniazid, which helped to curb the epidemic of tuberculosis which swept Europe after World War II. After the war, in 1947, Domagk was able to receive his Nobel Prize, but not the monetary portion of the prize due to the time that had elapsed.
In 1951, he was one of seven Nobel Laureates. Domagk became a Foreign Member of the Royal Society in 1959, he changed his focus to chemotherapy against cancer. He continued to work in Wuppertal. Domagk died from a heart attack in Burgberg near Königsfeld, Schwarzwald
Simplified molecular-input line-entry system
The simplified molecular-input line-entry system is a specification in the form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules; the original SMILES specification was initiated in the 1980s. It has since been extended. In 2007, an open standard called. Other linear notations include the Wiswesser line notation, ROSDAL, SYBYL Line Notation; the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. Acknowledged for their parts in the early development were "Gilman Veith and Rose Russo and Albert Leo and Corwin Hansch for supporting the work, Arthur Weininger and Jeremy Scofield for assistance in programming the system." The Environmental Protection Agency funded the initial project to develop SMILES. It has since been modified and extended by others, most notably by Daylight Chemical Information Systems.
In 2007, an open standard called "OpenSMILES" was developed by the Blue Obelisk open-source chemistry community. Other'linear' notations include the Wiswesser Line Notation, ROSDAL and SLN. In July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is considered to have the advantage of being more human-readable than InChI; the term SMILES refers to a line notation for encoding molecular structures and specific instances should be called SMILES strings. However, the term SMILES is commonly used to refer to both a single SMILES string and a number of SMILES strings; the terms "canonical" and "isomeric" can lead to some confusion when applied to SMILES. The terms are not mutually exclusive. A number of valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol. Algorithms have been developed to generate the same SMILES string for a given molecule; this SMILES is unique for each structure, although dependent on the canonicalization algorithm used to generate it, is termed the canonical SMILES.
These algorithms first convert the SMILES to an internal representation of the molecular structure. Various algorithms for generating canonical SMILES have been developed and include those by Daylight Chemical Information Systems, OpenEye Scientific Software, MEDIT, Chemical Computing Group, MolSoft LLC, the Chemistry Development Kit. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database; the original paper that described the CANGEN algorithm claimed to generate unique SMILES strings for graphs representing molecules, but the algorithm fails for a number of simple cases and cannot be considered a correct method for representing a graph canonically. There is no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, double bond geometry; these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES.
A notable feature of these rules is. The term isomeric SMILES is applied to SMILES in which isotopes are specified. In terms of a graph-based computational procedure, SMILES is a string obtained by printing the symbol nodes encountered in a depth-first tree traversal of a chemical graph; the chemical graph is first trimmed to remove hydrogen atoms and cycles are broken to turn it into a spanning tree. Where cycles have been broken, numeric suffix labels are included to indicate the connected nodes. Parentheses are used to indicate points of branching on the tree; the resultant SMILES form depends on the choices: of the bonds chosen to break cycles, of the starting atom used for the depth-first traversal, of the order in which branches are listed when encountered. Atoms are represented by the standard abbreviation of the chemical elements, in square brackets, such as for gold. Brackets may be omitted in the common case of atoms which: are in the "organic subset" of B, C, N, O, P, S, F, Cl, Br, or I, have no formal charge, have the number of hydrogens attached implied by the SMILES valence model, are the normal isotopes, are not chiral centers.
All other elements must be enclosed in brackets, have charges and hydrogens shown explicitly. For instance, the SMILES for water may be written as either O or. Hydrogen may be written as a separate atom; when brackets are used, the symbol H is added if the atom in brackets is bonded to one or more hydrogen, followed by the number of hydrogen atoms if greater than 1 by the sign + for a positive charge or by - for a negative charge. For example, for ammonium. If there is more than one charge, it is written as digit.
World War II
World War II known as the Second World War, was a global war that lasted from 1939 to 1945. The vast majority of the world's countries—including all the great powers—eventually formed two opposing military alliances: the Allies and the Axis. A state of total war emerged, directly involving more than 100 million people from over 30 countries; the major participants threw their entire economic and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. World War II was the deadliest conflict in human history, marked by 50 to 85 million fatalities, most of whom were civilians in the Soviet Union and China, it included massacres, the genocide of the Holocaust, strategic bombing, premeditated death from starvation and disease, the only use of nuclear weapons in war. Japan, which aimed to dominate Asia and the Pacific, was at war with China by 1937, though neither side had declared war on the other. World War II is said to have begun on 1 September 1939, with the invasion of Poland by Germany and subsequent declarations of war on Germany by France and the United Kingdom.
From late 1939 to early 1941, in a series of campaigns and treaties, Germany conquered or controlled much of continental Europe, formed the Axis alliance with Italy and Japan. Under the Molotov–Ribbentrop Pact of August 1939, Germany and the Soviet Union partitioned and annexed territories of their European neighbours, Finland and the Baltic states. Following the onset of campaigns in North Africa and East Africa, the fall of France in mid 1940, the war continued between the European Axis powers and the British Empire. War in the Balkans, the aerial Battle of Britain, the Blitz, the long Battle of the Atlantic followed. On 22 June 1941, the European Axis powers launched an invasion of the Soviet Union, opening the largest land theatre of war in history; this Eastern Front trapped most crucially the German Wehrmacht, into a war of attrition. In December 1941, Japan launched a surprise attack on the United States as well as European colonies in the Pacific. Following an immediate U. S. declaration of war against Japan, supported by one from Great Britain, the European Axis powers declared war on the U.
S. in solidarity with their Japanese ally. Rapid Japanese conquests over much of the Western Pacific ensued, perceived by many in Asia as liberation from Western dominance and resulting in the support of several armies from defeated territories; the Axis advance in the Pacific halted in 1942. Key setbacks in 1943, which included a series of German defeats on the Eastern Front, the Allied invasions of Sicily and Italy, Allied victories in the Pacific, cost the Axis its initiative and forced it into strategic retreat on all fronts. In 1944, the Western Allies invaded German-occupied France, while the Soviet Union regained its territorial losses and turned toward Germany and its allies. During 1944 and 1945 the Japanese suffered major reverses in mainland Asia in Central China, South China and Burma, while the Allies crippled the Japanese Navy and captured key Western Pacific islands; the war in Europe concluded with an invasion of Germany by the Western Allies and the Soviet Union, culminating in the capture of Berlin by Soviet troops, the suicide of Adolf Hitler and the German unconditional surrender on 8 May 1945.
Following the Potsdam Declaration by the Allies on 26 July 1945 and the refusal of Japan to surrender under its terms, the United States dropped atomic bombs on the Japanese cities of Hiroshima and Nagasaki on 6 and 9 August respectively. With an invasion of the Japanese archipelago imminent, the possibility of additional atomic bombings, the Soviet entry into the war against Japan and its invasion of Manchuria, Japan announced its intention to surrender on 15 August 1945, cementing total victory in Asia for the Allies. Tribunals were set up by fiat by the Allies and war crimes trials were conducted in the wake of the war both against the Germans and the Japanese. World War II changed the political social structure of the globe; the United Nations was established to foster international co-operation and prevent future conflicts. The Soviet Union and United States emerged as rival superpowers, setting the stage for the nearly half-century long Cold War. In the wake of European devastation, the influence of its great powers waned, triggering the decolonisation of Africa and Asia.
Most countries whose industries had been damaged moved towards economic expansion. Political integration in Europe, emerged as an effort to end pre-war enmities and create a common identity; the start of the war in Europe is held to be 1 September 1939, beginning with the German invasion of Poland. The dates for the beginning of war in the Pacific include the start of the Second Sino-Japanese War on 7 July 1937, or the Japanese invasion of Manchuria on 19 September 1931. Others follow the British historian A. J. P. Taylor, who held that the Sino-Japanese War and war in Europe and its colonies occurred and the two wars merged in 1941; this article uses the conventional dating. Other starting dates sometimes used for World War II include the Italian invasion of Abyssinia on 3 October 1935; the British historian Antony Beevor views the beginning of World War II as the Battles of Khalkhin Gol fought between Japan and the fo
Vienna is the federal capital and largest city of Austria, one of the nine states of Austria. Vienna is Austria's primate city, with a population of about 1.9 million, its cultural and political centre. It is the 7th-largest city by population within city limits in the European Union; until the beginning of the 20th century, it was the largest German-speaking city in the world, before the splitting of the Austro-Hungarian Empire in World War I, the city had 2 million inhabitants. Today, it has the second largest number of German speakers after Berlin. Vienna is host to many major international organizations, including the United Nations and OPEC; the city is located in the eastern part of Austria and is close to the borders of the Czech Republic and Hungary. These regions work together in a European Centrope border region. Along with nearby Bratislava, Vienna forms a metropolitan region with 3 million inhabitants. In 2001, the city centre was designated a UNESCO World Heritage Site. In July 2017 it was moved to the list of World Heritage in Danger.
Apart from being regarded as the City of Music because of its musical legacy, Vienna is said to be "The City of Dreams" because it was home to the world's first psychoanalyst – Sigmund Freud. The city's roots lie in early Celtic and Roman settlements that transformed into a Medieval and Baroque city, the capital of the Austro-Hungarian Empire, it is well known for having played an essential role as a leading European music centre, from the great age of Viennese Classicism through the early part of the 20th century. The historic centre of Vienna is rich in architectural ensembles, including Baroque castles and gardens, the late-19th-century Ringstraße lined with grand buildings and parks. Vienna is known for its high quality of life. In a 2005 study of 127 world cities, the Economist Intelligence Unit ranked the city first for the world's most liveable cities. Between 2011 and 2015, Vienna was ranked second, behind Melbourne. In 2018, it replaced Melbourne as the number one spot. For ten consecutive years, the human-resource-consulting firm Mercer ranked Vienna first in its annual "Quality of Living" survey of hundreds of cities around the world.
Monocle's 2015 "Quality of Life Survey" ranked Vienna second on a list of the top 25 cities in the world "to make a base within."The UN-Habitat classified Vienna as the most prosperous city in the world in 2012/2013. The city was ranked 1st globally for its culture of innovation in 2007 and 2008, sixth globally in the 2014 Innovation Cities Index, which analyzed 162 indicators in covering three areas: culture and markets. Vienna hosts urban planning conferences and is used as a case study by urban planners. Between 2005 and 2010, Vienna was the world's number-one destination for international congresses and conventions, it attracts over 6.8 million tourists a year. The English name Vienna is borrowed from the homonymous Italian version of the city's name or the French Vienne; the etymology of the city's name is still subject to scholarly dispute. Some claim that the name comes from Vedunia, meaning "forest stream", which subsequently produced the Old High German Uuenia, the New High German Wien and its dialectal variant Wean.
Others believe that the name comes from the Roman settlement name of Celtic extraction Vindobona meaning "fair village, white settlement" from Celtic roots, vindo-, meaning "bright" or "fair" – as in the Irish fionn and the Welsh gwyn –, -bona "village, settlement". The Celtic word Vindos may reflect a widespread prehistorical cult of a Celtic God. A variant of this Celtic name could be preserved in the Czech and Polish names of the city and in that of the city's district Wieden; the name of the city in Hungarian, Serbo-Croatian and Ottoman Turkish has a different Slavonic origin, referred to an Avar fort in the area. Slovene-speakers call the city Dunaj, which in other Central European Slavic languages means the Danube River, on which the city stands. Evidence has been found of continuous habitation in the Vienna area since 500 BC, when Celts settled the site on the Danube River. In 15 BC the Romans fortified the frontier city they called Vindobona to guard the empire against Germanic tribes to the north.
Close ties with other Celtic peoples continued through the ages. The Irish monk Saint Colman is buried in Melk Abbey and Saint Fergil served as Bishop of Salzburg for forty years. Irish Benedictines founded twelfth-century monastic settlements. Evidence of these ties persists in the form of Vienna's great Schottenstift monastery, once home to many Irish monks. In 976 Leopold I of Babenberg became count of the Eastern March, a 60-mile district centering on the Danube on the eastern frontier of Bavaria; this initial district grew into the duchy of Austria. Each succeeding Babenberg ruler expanded the march east along the Danube encompassing Vienna and the lands east. In 1145 Duke Henry II Jasomirgott moved the Babenberg family residence from Klosterneuburg in Lower Austria to Vienna. From that time, Vienna remained the center of the Babenberg dynasty. In 1440 Vienna became the resident city of the Habsburg dynasty, it grew to become the de facto capital of the Holy Roman Empire in 1437 and a cultural centre for arts and science and fine cuisine.
Hungary occupied the city between 1485 and 1490. In the 16th and 1
Mammals are vertebrate animals constituting the class Mammalia, characterized by the presence of mammary glands which in females produce milk for feeding their young, a neocortex, fur or hair, three middle ear bones. These characteristics distinguish them from reptiles and birds, from which they diverged in the late Triassic, 201–227 million years ago. There are around 5,450 species of mammals; the largest orders are the rodents and Soricomorpha. The next three are the Primates, the Cetartiodactyla, the Carnivora. In cladistics, which reflect evolution, mammals are classified as endothermic amniotes, they are the only living Synapsida. The early synapsid mammalian ancestors were sphenacodont pelycosaurs, a group that produced the non-mammalian Dimetrodon. At the end of the Carboniferous period around 300 million years ago, this group diverged from the sauropsid line that led to today's reptiles and birds; the line following the stem group Sphenacodontia split off several diverse groups of non-mammalian synapsids—sometimes referred to as mammal-like reptiles—before giving rise to the proto-mammals in the early Mesozoic era.
The modern mammalian orders arose in the Paleogene and Neogene periods of the Cenozoic era, after the extinction of non-avian dinosaurs, have been among the dominant terrestrial animal groups from 66 million years ago to the present. The basic body type is quadruped, most mammals use their four extremities for terrestrial locomotion. Mammals range in size from the 30–40 mm bumblebee bat to the 30-meter blue whale—the largest animal on the planet. Maximum lifespan varies from two years for the shrew to 211 years for the bowhead whale. All modern mammals give birth to live young, except the five species of monotremes, which are egg-laying mammals; the most species-rich group of mammals, the cohort called placentals, have a placenta, which enables the feeding of the fetus during gestation. Most mammals are intelligent, with some possessing large brains, self-awareness, tool use. Mammals can communicate and vocalize in several different ways, including the production of ultrasound, scent-marking, alarm signals and echolocation.
Mammals can organize themselves into fission-fusion societies and hierarchies—but can be solitary and territorial. Most mammals are polygynous. Domestication of many types of mammals by humans played a major role in the Neolithic revolution, resulted in farming replacing hunting and gathering as the primary source of food for humans; this led to a major restructuring of human societies from nomadic to sedentary, with more co-operation among larger and larger groups, the development of the first civilizations. Domesticated mammals provided, continue to provide, power for transport and agriculture, as well as food and leather. Mammals are hunted and raced for sport, are used as model organisms in science. Mammals have been depicted in art since Palaeolithic times, appear in literature, film and religion. Decline in numbers and extinction of many mammals is driven by human poaching and habitat destruction deforestation. Mammal classification has been through several iterations since Carl Linnaeus defined the class.
No classification system is universally accepted. George Gaylord Simpson's "Principles of Classification and a Classification of Mammals" provides systematics of mammal origins and relationships that were universally taught until the end of the 20th century. Since Simpson's classification, the paleontological record has been recalibrated, the intervening years have seen much debate and progress concerning the theoretical underpinnings of systematization itself through the new concept of cladistics. Though field work made Simpson's classification outdated, it remains the closest thing to an official classification of mammals. Most mammals, including the six most species-rich orders, belong to the placental group; the three largest orders in numbers of species are Rodentia: mice, porcupines, beavers and other gnawing mammals. The next three biggest orders, depending on the biological classification scheme used, are the Primates including the apes and lemurs. According to Mammal Species of the World, 5,416 species were identified in 2006.
These were grouped into 153 families and 29 orders. In 2008, the International Union for Conservation of Nature completed a five-year Global Mammal Assessment for its IUCN Red List, which counted 5,488 species. According to a research published in the Journal of Mammalogy in 2018, the number of recognized mammal species is 6,495 species included 96 extinct; the word "mammal" is modern, from the scientific name Mammalia coined by Carl Linnaeus in 1758, derived from the Latin mamma. In an influential 1988 paper, Timothy Rowe defined Mammalia phylogenetically as the crown group of mammals, the clade consisting of the most recent common ancestor of living monotremes and therian m
The density, or more the volumetric mass density, of a substance is its mass per unit volume. The symbol most used for density is ρ, although the Latin letter D can be used. Mathematically, density is defined as mass divided by volume: ρ = m V where ρ is the density, m is the mass, V is the volume. In some cases, density is loosely defined as its weight per unit volume, although this is scientifically inaccurate – this quantity is more called specific weight. For a pure substance the density has the same numerical value as its mass concentration. Different materials have different densities, density may be relevant to buoyancy and packaging. Osmium and iridium are the densest known elements at standard conditions for temperature and pressure but certain chemical compounds may be denser. To simplify comparisons of density across different systems of units, it is sometimes replaced by the dimensionless quantity "relative density" or "specific gravity", i.e. the ratio of the density of the material to that of a standard material water.
Thus a relative density less than one means. The density of a material varies with pressure; this variation is small for solids and liquids but much greater for gases. Increasing the pressure on an object decreases the volume of the object and thus increases its density. Increasing the temperature of a substance decreases its density by increasing its volume. In most materials, heating the bottom of a fluid results in convection of the heat from the bottom to the top, due to the decrease in the density of the heated fluid; this causes it to rise relative to more dense unheated material. The reciprocal of the density of a substance is called its specific volume, a term sometimes used in thermodynamics. Density is an intensive property in that increasing the amount of a substance does not increase its density. In a well-known but apocryphal tale, Archimedes was given the task of determining whether King Hiero's goldsmith was embezzling gold during the manufacture of a golden wreath dedicated to the gods and replacing it with another, cheaper alloy.
Archimedes knew that the irregularly shaped wreath could be crushed into a cube whose volume could be calculated and compared with the mass. Baffled, Archimedes is said to have taken an immersion bath and observed from the rise of the water upon entering that he could calculate the volume of the gold wreath through the displacement of the water. Upon this discovery, he leapt from his bath and ran naked through the streets shouting, "Eureka! Eureka!". As a result, the term "eureka" entered common parlance and is used today to indicate a moment of enlightenment; the story first appeared in written form in Vitruvius' books of architecture, two centuries after it took place. Some scholars have doubted the accuracy of this tale, saying among other things that the method would have required precise measurements that would have been difficult to make at the time. From the equation for density, mass density has units of mass divided by volume; as there are many units of mass and volume covering many different magnitudes there are a large number of units for mass density in use.
The SI unit of kilogram per cubic metre and the cgs unit of gram per cubic centimetre are the most used units for density. One g/cm3 is equal to one thousand kg/m3. One cubic centimetre is equal to one millilitre. In industry, other larger or smaller units of mass and or volume are more practical and US customary units may be used. See below for a list of some of the most common units of density. A number of techniques as well as standards exist for the measurement of density of materials; such techniques include the use of a hydrometer, Hydrostatic balance, immersed body method, air comparison pycnometer, oscillating densitometer, as well as pour and tap. However, each individual method or technique measures different types of density, therefore it is necessary to have an understanding of the type of density being measured as well as the type of material in question; the density at all points of a homogeneous object equals its total mass divided by its total volume. The mass is measured with a scale or balance.
To determine the density of a liquid or a gas, a hydrometer, a dasymeter or a Coriolis flow meter may be used, respectively. Hydrostatic weighing uses the displacement of water due to a submerged object to determine the density of the object. If the body is not homogeneous its density varies between different regions of the object. In that case the density around any given location is determined by calculating the density of a small volume around that location. In the limit of an infinitesimal volume the density of an inhomogeneous object at a point becomes: ρ = d m / d V, where d V is an elementary volume at position r; the mass of the body t
Nazi human experimentation
Nazi human experimentation was a series of medical experiments on large numbers of prisoners, including children, by Nazi Germany in its concentration camps in the early to mid 1940s, during World War II and the Holocaust. Chief target populations included Romani, ethnic Poles, Soviet POWs, disabled Germans, Jews from across Europe. Nazi physicians and their assistants forced prisoners into participating; the experiments resulted in death, disfigurement or permanent disability, as such are considered examples of medical torture. At Auschwitz and other camps, under the direction of Eduard Wirths, selected inmates were subjected to various hazardous experiments that were designed to help German military personnel in combat situations, develop new weapons, aid in the recovery of military personnel, injured, to advance the Nazi racial ideology. Aribert Heim conducted similar medical experiments at Mauthausen. After the war, these crimes were tried at what became known as the Doctors' Trial, revulsion at the abuses perpetrated led to the development of the Nuremberg Code of medical ethics.
The Nazi physicians in the Doctors' Trial argued that military necessity justified their torturous experiments, compared their victims to collateral damage from Allied bombings. But this defense, in any case rejected by the Tribunal, cannot apply to the twin experiments of Josef Mengele, which were performed on children and had no connection to military necessity; the table of contents of a document from the Nuremberg military tribunals prosecution includes titles of the sections that document medical experiments revolving around: food, epidemic jaundice, blood coagulation and phlegmone. According to the indictments at the Subsequent Nuremberg Trials, these experiments included the following: Experiments on twin children in concentration camps were created to show the similarities and differences in the genetics of twins, as well as to see if the human body can be unnaturally manipulated; the central leader of the experiments was Josef Mengele, who from 1943 to 1944 performed experiments on nearly 1,500 sets of imprisoned twins at Auschwitz.
About 200 people survived these studies. The twins were arranged by age and sex and kept in barracks between experiments, which ranged from injection of different dyes into the eyes of twins to see whether it would change their color to sewing twins together in attempts to create conjoined twins. Times, one twin would be forced to undergo experimentation, while the other was kept as a control. If the experimentation reached the point of death, the second twin would be brought in to be killed at the same time. Doctors would look at the effects of experimentation and compare both bodies. From about September 1942 to about December 1943 experiments were conducted at the Ravensbrück concentration camp, for the benefit of the German Armed Forces, to study bone and nerve regeneration, bone transplantation from one person to another. Sections of bones and nerves were removed from the subjects without use of anesthesia; as a result of these operations, many victims suffered intense agony and permanent disability.
On August 12, 1946 a survivor named Jadwiga Kamińska gave a deposition about her time at Ravensbrück concentration camp and describes how she was operated on twice. Both operations involved one of her legs and although she never describes having any knowledge as to what the procedure was, she explains that both times she was in extreme pain and developed a fever post surgery, yet she was given little to no care. Kamińska describes being told that she had been operated on because she was a "young girl and a Polish patriot", she describes. Prisoners were experimented on by having their bone marrow injected with bacteria to study the effectiveness of new drugs being developed for use in the battle fields. Many prisoners left the camps with disfigurement. In mid-1942 in Baranowicze, occupied Poland, experiments were conducted in a small building behind the private home occupied by a known Nazi SD Security Service officer, in which "a young boy of eleven or twelve strapped to a chair so he could not move.
Above him was a mechanized hammer that every few seconds came down upon his head." The boy was driven insane from the torture. In 1941, the Luftwaffe conducted experiments with the intent of discovering means to prevent and treat hypothermia. There were 360 to 400 experiments and 280 to 300 victims indicating some victims suffered more than one experiment. Another study placed prisoners naked in the open air for several hours with temperatures as low as −6 °C. Besides studying the physical effects of cold exposure, the experimenters assessed different methods of rewarming survivors. "One assistant testified that some victims were thrown into boiling water for rewarming."Beginning in August 1942, at the Dachau camp, prisoners were forced to sit in tanks of freezing water for up to 3 hours. After subjects were frozen, they underwent different methods for rewarming. Many subjects died in this process; the freezing/hypothermia experiments were conducted for the Nazi high command to simulate the conditions the armies suffered on the Eastern Front, as the German forces were ill-prepared for the cold weather they encountered.
Many experiments were conducted on captured Russian troops. The principal locales were Auschwitz. Sigmund Rascher, an SS doctor based at Dachau, reported directly to Reichsführer-SS Heinrich Himmler and publicised