New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is located on a peninsula, bordered on the north and east by the state of New York along the extent of the length of New York City on its western edge. New Jersey is the fourth-smallest state by area but the 11th-most populous, with 9 million residents as of 2017, the most densely populated of the 50 U. S. states. New Jersey lies within the combined statistical areas of New York City and Philadelphia. New Jersey was the second-wealthiest U. S. state by median household income as of 2017. New Jersey was inhabited by Native Americans for more than 2,800 years, with historical tribes such as the Lenape along the coast. In the early 17th century, the Dutch and the Swedes founded the first European settlements in the state; the English seized control of the region, naming it the Province of New Jersey after the largest of the Channel Islands and granting it as a colony to Sir George Carteret and John Berkeley, 1st Baron Berkeley of Stratton.
New Jersey was the site of several decisive battles during the American Revolutionary War in the 18th century. In the 19th century, factories in cities, Paterson, Trenton, Jersey City, Elizabeth helped to drive the Industrial Revolution. New Jersey's geographic location at the center of the Northeast megalopolis, between Boston and New York City to the northeast, Philadelphia and Washington, D. C. to the southwest, fueled its rapid growth through the process of suburbanization in the second half of the 20th century. In the first decades of the 21st century, this suburbanization began reverting with the consolidation of New Jersey's culturally diverse populace toward more urban settings within the state, with towns home to commuter rail stations outpacing the population growth of more automobile-oriented suburbs since 2008. Around 180 million years ago, during the Jurassic Period, New Jersey bordered North Africa; the pressure of the collision between North America and Africa gave rise to the Appalachian Mountains.
Around 18,000 years ago, the Ice Age resulted in glaciers. As the glaciers retreated, they left behind Lake Passaic, as well as many rivers and gorges. New Jersey was settled by Native Americans, with the Lenni-Lenape being dominant at the time of contact. Scheyichbi is the Lenape name for the land, now New Jersey; the Lenape were several autonomous groups that practiced maize agriculture in order to supplement their hunting and gathering in the region surrounding the Delaware River, the lower Hudson River, western Long Island Sound. The Lenape society was divided into matrilinear clans; these clans were organized into three distinct phratries identified by their animal sign: Turtle and Wolf. They first encountered the Dutch in the early 17th century, their primary relationship with the Europeans was through fur trade; the Dutch became the first Europeans to lay claim to lands in New Jersey. The Dutch colony of New Netherland consisted of parts of modern Middle Atlantic states. Although the European principle of land ownership was not recognized by the Lenape, Dutch West India Company policy required its colonists to purchase the land that they settled.
The first to do so was Michiel Pauw who established a patronship called Pavonia in 1630 along the North River which became the Bergen. Peter Minuit's purchase of lands along the Delaware River established the colony of New Sweden; the entire region became a territory of England on June 24, 1664, after an English fleet under the command of Colonel Richard Nicolls sailed into what is now New York Harbor and took control of Fort Amsterdam, annexing the entire province. During the English Civil War, the Channel Island of Jersey remained loyal to the British Crown and gave sanctuary to the King, it was from the Royal Square in Saint Helier that Charles II of England was proclaimed King in 1649, following the execution of his father, Charles I. The North American lands were divided by Charles II, who gave his brother, the Duke of York, the region between New England and Maryland as a proprietary colony. James granted the land between the Hudson River and the Delaware River to two friends who had remained loyal through the English Civil War: Sir George Carteret and Lord Berkeley of Stratton.
The area was named the Province of New Jersey. Since the state's inception, New Jersey has been characterized by religious diversity. New England Congregationalists settled alongside Scots Presbyterians and Dutch Reformed migrants. While the majority of residents lived in towns with individual landholdings of 100 acres, a few rich proprietors owned vast estates. English Quakers and Anglicans owned large landholdings. Unlike Plymouth Colony and other colonies, New Jersey was populated by a secondary wave of immigrants who came from other colonies instead of those who migrated directly from Europe. New Jersey remained agrarian and rural throughout the colonial era, commercial farming developed sporadically; some townships, such as Burlington on the Delaware River and Perth Amboy, emerged as important ports for shipping to New York City and Philadelphia. The colony's fertile lands and tolerant religious policy drew more settlers, New Jersey's population had increased to 120,000 by 1775. Settlement for the first 10 years of English rule took place along Hackensack River and Arthur Kill –
Fort Lee, New Jersey
Fort Lee is a borough at the eastern border of Bergen County, New Jersey, United States, in the New York City Metropolitan Area, situated atop the Hudson Palisades. As of the 2010 United States Census, the borough's population was 35,345, reflecting a decline of 116 from the 35,461 counted in the 2000 Census, which had in turn increased by 3,464 from the 31,997 counted in the 1990 Census; the borough is the western terminus of the George Washington Bridge and is located across the Hudson River from the Manhattan borough of New York City. Named for the site of an early American Revolutionary War military encampment, it became the birthplace of the American film industry. According to the United States Census Bureau, the borough had a total area of 2.888 square miles, including 2.541 square miles of land and 0.347 square miles of water. The borough is situated atop the escarpment of the Hudson Palisades on the peninsula between the Hackensack and Hudson rivers; the borough is bisected by the confluence of roads at GWB Plaza leading to the George Washington Bridge.
Unincorporated communities and place names located or within the borough include Coytesville and Taylorville. The borough borders Cliffside Park, Englewood, Englewood Cliffs, Palisades Park, Ridgefield. and the Washington Heights neighborhood of Upper Manhattan. Given its evolving cosmopolitan ambiance and adjacent proximity to Manhattan, Fort Lee is one of Northern New Jersey's Hudson Waterfront communities, called New York City's Sixth Borough, Fort Lee is named for General Charles Lee after George Washington and his troops had camped at Mount Constitution overlooking Burdett's Landing, in defense of New York City, it was during Washington's retreat in November 1776 that Thomas Paine composed his pamphlet, The American Crisis, which began with the recognized phrase, "These are the times that try men's souls." These events are recalled at Fort Lee Historic Park. Fort Lee was formed by an act of the New Jersey Legislature on March 29, 1904, from the remaining portions of Ridgefield Township.
With the creation of Fort Lee, Ridgefield Township became defunct and was dissolved as of March 29, 1904. The Fort Lee Police Department was formed under borough ordinance on August 9, 1904, consisted of six marshals; the history of cinema in the United States can trace its roots to the East Coast where, at one time, Fort Lee was the motion picture capital of America. The industry got its start at the end of the 19th century with the construction of Thomas Edison's "Black Maria", the first motion picture studio in West Orange, New Jersey. New Jersey offered land at costs less than New York City, the cities and towns on the North River and Hudson Palisades benefited as a result of the phenomenal growth of the film industry at the turn of the 20th century. Film-making began attracting both capital and an innovative workforce, when the Kalem Company began using Fort Lee in 1907 as a location for filming in the area, other filmmakers followed. In 1909, a forerunner of Universal Studios, the Champion Film Company, built the first studio.
They were followed by others who either built new studios or who leased facilities in Fort Lee. In the 1910s and 1920s, film companies such as the Independent Moving Pictures Company, Peerless Studios, The Solax Company, Éclair Studios, Goldwyn Picture Corporation, American Méliès, World Film Company, Biograph Studios, Fox Film Corporation, Pathé Frères, Metro Pictures Corporation, Victor Film Company, Selznick Pictures Corporation were all making pictures in Fort Lee; such notables as Mary Pickford got their start at Biograph Studios. With the offshoot businesses that sprang up to service the film studios, for nearly two decades Fort Lee experienced unrivaled prosperity. However, just as the development of Fort Lee production facilities were gaining strength, Nestor Studios of Bayonne, New Jersey, built the first studio in Hollywood in 1911. Nestor Studios, owned by David and William Horsley merged with Universal Studios. California's more hospitable and cost-effective climate led to the eventual shift of all filmmaking to the West Coast by the 1930s.
At the time, Thomas Edison owned all the patents relevant to motion picture production. Movie producers on the East Coast acting independently of Edison's Motion Picture Patents Company were sued or enjoined by Edison and his agents, while movie makers working on the West Coast could work independently of Edison's control, in part due to the Ninth Circuit Court of Appeals–which was headquartered in San Francisco and covered most of Southern California–being well known not to enforce patents claims. Television and film in New Jersey remains an important industry. Since 2000, the Fort Lee Film Commission has been charged with celebrating the history of film in Fort Lee, as well as attracting film and television production companies to the borough, they will be opening the Barrymore Film Center to promote film making and its history. In 1957, market researcher James Vicary claimed that flashing messages on a movie screen, in Fort Lee, had influenced people to purchase more food and drinks. Vicary coined the term subliminal advertising and formed the Subliminal Projection Company based on a six-week test.
Vicary claimed that during the presentation of the movie Picnic he used a tachistoscope to project the words "Drink Coca-Cola" and "Hungry? Eat popcorn" for 1/3000 of a second a
The pharmaceutical industry discovers, develops and markets drugs or pharmaceutical drugs for use as medications to be administered to patients to cure them, vaccinate them, or alleviate a symptom. Pharmaceutical companies may deal in medical devices, they are subject to a variety of laws and regulations that govern the patenting, safety and marketing of drugs. The modern pharmaceutical industry traces its roots to two sources; the first of these were local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid 1800s. Rational drug discovery from plants started with the isolation of morphine and sleep-inducing agent from opium, by the German apothecary assistant Friedrich Sertürner who named the compound after the Greek god of dreams, Morpheus. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had established rudimentary methods in organic chemical synthesis.
The development of synthetic chemical methods allowed scientists to systematically vary the structure of chemical substances, growth in the emerging science of pharmacology expanded their ability to evaluate the biological effects of these structural changes. By the 1890s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs; the blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897, John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine developed a method for obtaining epinephrine in a pure state, licensed the technology to Parke-Davis.
Parke-Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be efficacious for the acute treatment of asthma attacks, an inhaled version was sold in the United States until 2011. By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion. While effective, the requirement for injection limited the use of epinephrine and orally active derivatives were sought. A structurally similar compound, was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome, academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929; the drug proved to have only modest anti-asthma effects, but produced sensations of exhilaration and palpitations. Amphetamine was developed by Smith and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was developed for the treatment of narcolepsy, post-encephalitic parkinsonism, mood elevation in depression and other psychiatric indications.
It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937 and remained in common use for depression until the development of tricyclic antidepressants in the 1960s. In 1903, Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs; the discovery was patented and licensed to Bayer pharmaceuticals, which marketed the compound under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most used drugs for the treatment of epilepsy through the 1970s, as of 2014, remains on the World Health Organizations list of essential medications; the 1950s and 1960s saw increased awareness of the addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers.
Today, amphetamine is restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy. A series of experiments performed from the late 1800s to the early 1900s revealed that diabetes is caused by the absence of a substance produced by the pancreas. In 1869, Oskar Minkowski and Joseph von Mering found that diabetes could be induced in dogs by surgical removal of the pancreas. In 1921, Canadian professor Frederick Banting and his student Charles Best repeated this study, found that injections of pancreatic extract reversed the symptoms produced by pancreas removal. Soon, the extract was demonstrated to work in people, but development of insulin therapy as a routine medical procedure was delayed by difficulties in producing the material in sufficient quantity and with reproducible purity; the researchers sought assistance from industrial collaborators at Eli Lilly and Co. based on the company's experience with large scale purification of biological materials.
Chemist George B. Walden of Eli Lilly and Company found that careful adjustment of the pH of the extract allowed a pure grade of insulin to be produced. Under pressure from Toronto Un
The United States of America known as the United States or America, is a country composed of 50 states, a federal district, five major self-governing territories, various possessions. At 3.8 million square miles, the United States is the world's third or fourth largest country by total area and is smaller than the entire continent of Europe's 3.9 million square miles. With a population of over 327 million people, the U. S. is the third most populous country. The capital is Washington, D. C. and the largest city by population is New York City. Forty-eight states and the capital's federal district are contiguous in North America between Canada and Mexico; the State of Alaska is in the northwest corner of North America, bordered by Canada to the east and across the Bering Strait from Russia to the west. The State of Hawaii is an archipelago in the mid-Pacific Ocean; the U. S. territories are scattered about the Pacific Ocean and the Caribbean Sea, stretching across nine official time zones. The diverse geography and wildlife of the United States make it one of the world's 17 megadiverse countries.
Paleo-Indians migrated from Siberia to the North American mainland at least 12,000 years ago. European colonization began in the 16th century; the United States emerged from the thirteen British colonies established along the East Coast. Numerous disputes between Great Britain and the colonies following the French and Indian War led to the American Revolution, which began in 1775, the subsequent Declaration of Independence in 1776; the war ended in 1783 with the United States becoming the first country to gain independence from a European power. The current constitution was adopted in 1788, with the first ten amendments, collectively named the Bill of Rights, being ratified in 1791 to guarantee many fundamental civil liberties; the United States embarked on a vigorous expansion across North America throughout the 19th century, acquiring new territories, displacing Native American tribes, admitting new states until it spanned the continent by 1848. During the second half of the 19th century, the Civil War led to the abolition of slavery.
By the end of the century, the United States had extended into the Pacific Ocean, its economy, driven in large part by the Industrial Revolution, began to soar. The Spanish–American War and World War I confirmed the country's status as a global military power; the United States emerged from World War II as a global superpower, the first country to develop nuclear weapons, the only country to use them in warfare, a permanent member of the United Nations Security Council. Sweeping civil rights legislation, notably the Civil Rights Act of 1964, the Voting Rights Act of 1965 and the Fair Housing Act of 1968, outlawed discrimination based on race or color. During the Cold War, the United States and the Soviet Union competed in the Space Race, culminating with the 1969 U. S. Moon landing; the end of the Cold War and the collapse of the Soviet Union in 1991 left the United States as the world's sole superpower. The United States is the world's oldest surviving federation, it is a representative democracy.
The United States is a founding member of the United Nations, World Bank, International Monetary Fund, Organization of American States, other international organizations. The United States is a developed country, with the world's largest economy by nominal GDP and second-largest economy by PPP, accounting for a quarter of global GDP; the U. S. economy is post-industrial, characterized by the dominance of services and knowledge-based activities, although the manufacturing sector remains the second-largest in the world. The United States is the world's largest importer and the second largest exporter of goods, by value. Although its population is only 4.3% of the world total, the U. S. holds 31% of the total wealth in the world, the largest share of global wealth concentrated in a single country. Despite wide income and wealth disparities, the United States continues to rank high in measures of socioeconomic performance, including average wage, human development, per capita GDP, worker productivity.
The United States is the foremost military power in the world, making up a third of global military spending, is a leading political and scientific force internationally. In 1507, the German cartographer Martin Waldseemüller produced a world map on which he named the lands of the Western Hemisphere America in honor of the Italian explorer and cartographer Amerigo Vespucci; the first documentary evidence of the phrase "United States of America" is from a letter dated January 2, 1776, written by Stephen Moylan, Esq. to George Washington's aide-de-camp and Muster-Master General of the Continental Army, Lt. Col. Joseph Reed. Moylan expressed his wish to go "with full and ample powers from the United States of America to Spain" to seek assistance in the revolutionary war effort; the first known publication of the phrase "United States of America" was in an anonymous essay in The Virginia Gazette newspaper in Williamsburg, Virginia, on April 6, 1776. The second draft of the Articles of Confederation, prepared by John Dickinson and completed by June 17, 1776, at the latest, declared "The name of this Confederation shall be the'United States of America'".
The final version of the Articles sent to the states for ratification in late 1777 contains the sentence "The Stile of this Confederacy shall be'The United States of America'". In June 1776, Thomas Jefferson wrote the phrase "UNITED STATES OF AMERICA" in all capitalized letters in the headline of his "original Rough draught" of the Declaration of Independence; this draft of the document did not surface unti
London is the capital and largest city of both England and the United Kingdom. Standing on the River Thames in the south-east of England, at the head of its 50-mile estuary leading to the North Sea, London has been a major settlement for two millennia. Londinium was founded by the Romans; the City of London, London's ancient core − an area of just 1.12 square miles and colloquially known as the Square Mile − retains boundaries that follow its medieval limits. The City of Westminster is an Inner London borough holding city status. Greater London is governed by the Mayor of the London Assembly. London is considered to be one of the world's most important global cities and has been termed the world's most powerful, most desirable, most influential, most visited, most expensive, sustainable, most investment friendly, most popular for work, the most vegetarian friendly city in the world. London exerts a considerable impact upon the arts, education, fashion, healthcare, professional services and development, tourism and transportation.
London ranks 26 out of 300 major cities for economic performance. It is one of the largest financial centres and has either the fifth or sixth largest metropolitan area GDP, it is the most-visited city as measured by international arrivals and has the busiest city airport system as measured by passenger traffic. It is the leading investment destination, hosting more international retailers and ultra high-net-worth individuals than any other city. London's universities form the largest concentration of higher education institutes in Europe. In 2012, London became the first city to have hosted three modern Summer Olympic Games. London has a diverse range of people and cultures, more than 300 languages are spoken in the region, its estimated mid-2016 municipal population was 8,787,892, the most populous of any city in the European Union and accounting for 13.4% of the UK population. London's urban area is the second most populous in the EU, after Paris, with 9,787,426 inhabitants at the 2011 census.
The population within the London commuter belt is the most populous in the EU with 14,040,163 inhabitants in 2016. London was the world's most populous city from c. 1831 to 1925. London contains four World Heritage Sites: the Tower of London. Other landmarks include Buckingham Palace, the London Eye, Piccadilly Circus, St Paul's Cathedral, Tower Bridge, Trafalgar Square and The Shard. London has numerous museums, galleries and sporting events; these include the British Museum, National Gallery, Natural History Museum, Tate Modern, British Library and West End theatres. The London Underground is the oldest underground railway network in the world. "London" is an ancient name, attested in the first century AD in the Latinised form Londinium. Over the years, the name has attracted many mythicising explanations; the earliest attested appears in Geoffrey of Monmouth's Historia Regum Britanniae, written around 1136. This had it that the name originated from a supposed King Lud, who had taken over the city and named it Kaerlud.
Modern scientific analyses of the name must account for the origins of the different forms found in early sources Latin, Old English, Welsh, with reference to the known developments over time of sounds in those different languages. It is agreed; this was adapted into Latin as Londinium and borrowed into Old English, the ancestor-language of English. The toponymy of the Common Brythonic form is much debated. A prominent explanation was Richard Coates's 1998 argument that the name derived from pre-Celtic Old European *lowonida, meaning "river too wide to ford". Coates suggested that this was a name given to the part of the River Thames which flows through London. However, most work has accepted a Celtic origin for the name, recent studies have favoured an explanation along the lines of a Celtic derivative of a proto-Indo-European root *lendh-, combined with the Celtic suffix *-injo- or *-onjo-. Peter Schrijver has suggested, on these grounds, that the name meant'place that floods'; until 1889, the name "London" applied to the City of London, but since it has referred to the County of London and Greater London.
"London" is sometimes written informally as "LDN". In 1993, the remains of a Bronze Age bridge were found on the south foreshore, upstream of Vauxhall Bridge; this bridge either reached a now lost island in it. Two of those timbers were radiocarbon dated to between 1750 BC and 1285 BC. In 2010 the foundations of a large timber structure, dated to between 4800 BC and 4500 BC, were found on the Thames's south foreshore, downstream of Vauxhall Bridge; the function of the mesolithic structure is not known. Both structures are on the south bank. Although there is evidence of scattered Brythonic settlements in the area, the first major settlement was founded by the Romans about four years after the invasion
The Associated Press is a U. S.-based not-for-profit news agency headquartered in New York City. Founded in 1846, it operates as a unincorporated association, its members are U. S. newspapers and broadcasters. Its Statement of News Values and Principles spells out its practices; the AP has earned 52 Pulitzer Prizes, including 31 for photography, since the award was established in 1917. The AP has counted the vote in U. S. elections since 1848, including national and local races down to the legislative level in all 50 states, along with key ballot measures. AP collects and verifies returns in every county, parish and town across the U. S. and declares winners in over 5,000 contests. The AP news report, distributed to its members and customers, is produced in English and Arabic. AP content is available on the agency's app, AP News. A 2017 study by NewsWhip revealed that AP content was more engaged with on Facebook than content from any individual English-language publisher; as of 2016, news collected by the AP was published and republished by more than 1,300 newspapers and broadcasters.
The AP operates 263 news bureaus in 106 countries. It operates the AP Radio Network, which provides newscasts twice hourly for broadcast and satellite radio and television stations. Many newspapers and broadcasters outside the United States are AP subscribers, paying a fee to use AP material without being contributing members of the cooperative; as part of their cooperative agreement with the AP, most member news organizations grant automatic permission for the AP to distribute their local news reports. The AP employs the "inverted pyramid" formula for writing which enables the news outlets to edit a story to fit its available publication area without losing the story's essentials. Cutbacks at rival United Press International in 1993 left the AP as the United States' primary news service, although UPI still produces and distributes stories and photos daily. Other English-language news services, such as the BBC, Reuters and the English-language service of Agence France-Presse, are based outside the United States.
The Associated Press was formed in May 1846 by five daily newspapers in New York City to share the cost of transmitting news of the Mexican–American War. The venture was organized by Moses Yale Beach, second publisher of The Sun, joined by the New York Herald, the New York Courier and Enquirer, The Journal of Commerce, the New York Evening Express; some historians believe. The New York Times became a member shortly after its founding in September 1851. Known as the New York Associated Press, the organization faced competition from the Western Associated Press, which criticized its monopolistic news gathering and price setting practices. An investigation completed in 1892 by Victor Lawson and publisher of the Chicago Daily News, revealed that several principals of the NYAP had entered into a secret agreement with United Press, a rival organization, to share NYAP news and the profits of reselling it; the revelations led to the demise of the NYAP and in December 1892, the Western Associated Press was incorporated in Illinois as The Associated Press.
A 1900 Illinois Supreme Court decision —that the AP was a public utility and operating in restraint of trade—resulted in AP's move from Chicago to New York City, where corporation laws were more favorable to cooperatives. When the AP was founded, news became a salable commodity; the invention of the rotary press allowed the New York Tribune in the 1870s to print 18,000 papers per hour. During the Civil War and Spanish–American War, there was a new incentive to print vivid, on-the-spot reporting. Melville Stone, who had founded the Chicago Daily News in 1875, served as AP General Manager from 1893 to 1921, he embraced the standards of accuracy and integrity. The cooperative grew under the leadership of Kent Cooper, who built up bureau staff in South America, Europe and, the Middle East, he introduced the "telegraph typewriter" or teletypewriter into newsrooms in 1914. In 1935, AP launched the Wirephoto network, which allowed transmission of news photographs over leased private telephone lines on the day they were taken.
This gave AP a major advantage over other news media outlets. While the first network was only between New York and San Francisco AP had its network across the whole United States. In 1945, the Supreme Court of the United States held in Associated Press v. United States that the AP had been violating the Sherman Antitrust Act by prohibiting member newspapers from selling or providing news to nonmember organizations as well as making it difficult for nonmember newspapers to join the AP; the decision facilitated the growth of its main rival United Press International, headed by Hugh Baillie from 1935 to 1955. AP entered the broadcast field in 1941. In 1994, it established a global video newsgathering agency. APTV merged with WorldWide Television News in 1998 to form APTN, which provides video to international broadcasters and websites. In 2004, AP moved its world headquarters from its longtime home at 50 Rockefeller Plaza to a huge building at 450 West 33rd Street in Manhattan—which houses the New York Daily News and the studios of New York's public television station, WNET.
In 2009, AP had more than 240 bureaus globally. Its mission—"to gather with economy and efficiency an accurate and impartial report of the news"—has not changed since its founding, but digital technology has made the distribution of the AP news report an interact
Pharmacology is the branch of biology concerned with the study of drug action, where a drug can be broadly defined as any man-made, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, organ, or organism. More it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals; the field encompasses drug composition and properties and drug design and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, toxicology, chemical biology and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, Pharmacokinetics studies the effects of biological systems on a drug. In broad terms, pharmacodynamics discusses the chemicals with biological receptors, pharmacokinetics discusses the absorption, distribution and excretion of chemicals from the biological systems.
Pharmacology is not synonymous with pharmacy and the two terms are confused. Pharmacology, a biomedical science, deals with the research and characterization of chemicals which show biological effects and the elucidation of cellular and organismal function in relation to these chemicals. In contrast, pharmacy, a health services profession, is concerned with application of the principles learned from pharmacology in its clinical settings. In either field, the primary contrast between the two are their distinctions between direct-patient care, for pharmacy practice, the science-oriented research field, driven by pharmacology; the origins of clinical pharmacology date back to the Middle Ages in Avicenna's The Canon of Medicine, Peter of Spain's Commentary on Isaac, John of St Amand's Commentary on the Antedotary of Nicholas. Clinical pharmacology owes much of its foundation to the work of William Withering. Pharmacology as a scientific discipline did not further advance until the mid-19th century amid the great biomedical resurgence of that period.
Before the second half of the nineteenth century, the remarkable potency and specificity of the actions of drugs such as morphine and digitalis were explained vaguely and with reference to extraordinary chemical powers and affinities to certain organs or tissues. The first pharmacology department was set up by Rudolf Buchheim in 1847, in recognition of the need to understand how therapeutic drugs and poisons produced their effects. Early pharmacologists focused on natural substances plant extracts. Pharmacology developed in the 19th century as a biomedical science that applied the principles of scientific experimentation to therapeutic contexts. Today pharmacologists use genetics, molecular biology and other advanced tools to transform information about molecular mechanisms and targets into therapies directed against disease, defects or pathogens, create methods for preventative care and personalized medicine; the word "pharmacology" is derived from Greek φάρμακον, pharmakon, "drug, spell" and -λογία, -logia "study of", "knowledge of".
The discipline of pharmacology can be divided into many sub disciplines each with a specific focus. Clinical pharmacology is the basic science of pharmacology with an added focus on the application of pharmacological principles and methods in the medical clinic and towards patient care and outcomes. Neuropharmacology is the study of the effects of medication on central and peripheral nervous system functioning. Psychopharmacology known as behavioral pharmacology, is the study of the effects of medication on the psyche, observing changed behaviors of the body and mind, how molecular events are manifest in a measurable behavioral form. Psychopharmacology is an interdisciplinary field which studies behavioral effects of psychoactive drugs, it incorporates approaches and techniques from neuropharmacology, animal behavior and behavioral neuroscience, is interested in the behavioral and neurobiological mechanisms of action of psychoactive drugs. Another goal of behavioral pharmacology is to develop animal behavioral models to screen chemical compounds with therapeutic potentials.
People in this field use small animals to study psychotherapeutic drugs such as antipsychotics and anxiolytics, drugs of abuse such as nicotine and methamphetamine. Ethopharmacology is a term, in use since the 1960s and derives from the Greek word ἦθος ethos meaning character and "pharmacology" the study of drug actions and mechanism. Cardiovascular pharmacology is the study of the effects of drugs on the entire cardiovascular system, including the heart and blood vessels. Pharmacogenetics is clinical testing of genetic variation that gives rise to differing response to drugs. Pharmacogenomics is the application of genomic technologies to drug discovery and further characterization of older drugs. Pharmacoepidemiology is the study of the effects of drugs in large numbers of people. Safety pharmacology specialises in detecting and investigating potential undesirable pharmacodynamic effects of new chemical entities on physiological functions in relation to exposure in the therapeutic range and above.
Systems pharmacology is