TRNA (guanine10-N2)-methyltransferase

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TRNA (guanine10-N2)-methyltransferase
Identifiers
EC number 2.1.1.214
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA (guanine10-N2)-methyltransferase (EC 2.1.1.214, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine10 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA

tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.

References[edit]

  1. ^ Purushothaman, S.K.; Bujnicki, J.M.; Grosjean, H.; Lapeyre, B. (2005). "Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA". Mol. Cell. Biol. 25 (11): 4359–4370. doi:10.1128/MCB.25.11.4359-4370.2005. PMC 1140639Freely accessible. PMID 15899842. 

External links[edit]