Taxoid 14beta-hydroxylase

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Taxoid 14beta-hydroxylase
Identifiers
EC number 1.14.13.146
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Taxoid 14beta-hydroxylase (EC 1.14.13.146) is an enzyme with systematic name 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O

Taxoid 14beta-hydroxylase requires cytochrome P450.

References[edit]

  1. ^ Jennewein, S.; Rithner, C.D.; Williams, R.M.; Croteau, R. (2003). "Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase". Arch. Biochem. Biophys. 413: 262–270. doi:10.1016/s0003-9861(03)00090-0. PMID 12729625. 

External links[edit]