Testosterone 17b-dehydrogenase (NADP+)

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Testosterone 17beta-dehydrogenase (NADP+)
Identifiers
EC number 1.1.1.64
CAS number 9028-63-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Testosterone 17beta-dehydrogenase (NADP+) (EC 1.1.1.64, 17-ketoreductase, NADP-dependent testosterone-17beta-oxidoreductase, testosterone 17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP+ 17-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

testosterone + NADP+ androstenedione + NADPH + H+

Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

References[edit]

  1. ^ Endahl, G.L.; Kochakia, C.D.; Hamm, D. (1960). "Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver". J. Biol. Chem. 235: 2792–2796. PMID 13696735.
  2. ^ Sweat, M.L.; Samuels, L.T.; Lumry, R. (1950). "Preparation and characterisation of the enzyme which converts testosterone to androstendione". J. Biol. Chem. 185: 75–84. PMID 15436478.
  3. ^ Villee, C.A.; Spencer, J.M. (1960). "Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver". J. Biol. Chem. 235: 3615–3619. PMID 13781425.

External links[edit]