Testosterone 17beta-dehydrogenase

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testosterone 17-beta-dehydrogenase (NAD+)
Identifiers
EC number 1.1.1.63
CAS number 9028-62-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
testosterone 17-beta-dehydrogenase (NADP+)
Identifiers
EC number 1.1.1.64
CAS number 9028-63-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants[edit]

There are two variants of the enzyme, one that uses NAD+ as a substrate, and one that uses NADP+ as acceptor.

NAD+[edit]

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.63) catalyzes the reaction

testosterone + NAD+ androst-4-ene-3,17-dione + NADH + H+

Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.

NADP+[edit]

This variant of testosterone 17beta-dehydrogenase (EC 1.1.1.64) catalyzes the reaction

testosterone + NADP+ androst-4-ene-3,17-dione + NADPH + H+

Thus, the two substrates of this enzyme are testosterone and NADP+, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H+.

References[edit]

  • Endahl GL, Kochakian CD, Hamm D (1960). "Separation of a Triphosphopyridine Nucleotide-specific from a Diphosphopyridine Nucleotide-specific 17β-Hydroxy-(testosterone)dehydrogenase of Guinea Pig Liver". J. Biol. Chem. 235: 2792–6. PMID 13696735. 
  • Sweat ML, Samuels LT, Lumry R (1950). "Preparation and characterization of the enzyme which converts testosterone to androstenedione". J. Biol. Chem. 185 (1): 75–84. PMID 15436478. 
  • Villee CA; Spencer JM (1960). "Some Properties of the Pyridine Nucleotide-specific 17β-Hydroxy Steroid Dehydrogenases of Guinea Pig Liver". J. Biol. Chem. 235: 3615–3619. PMID 13781425.