Tetrahydroberberine oxidase

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tetrahydroberberine oxidase
EC number1.3.3.8
CAS number114705-00-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a tetrahydroberberine oxidase (EC is an enzyme that catalyzes the chemical reaction

(S)-tetrahydroberberine + 2 O2 berberine + 2 H2O2

Thus, the two substrates of this enzyme are (S)-tetrahydroberberine and O2, whereas its two products are berberine and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-tetrahydroberberine:oxygen oxidoreductase. This enzyme is also called (S)-THB oxidase. This enzyme participates in alkaloid biosynthesis.


  • Amann M, Nagakura N, Zenk MH (1984). "(S)-Tetrahydroprotoberberine oxidase the final enzyme in protoberberine biosynthesis". Tetrahedron Lett. 25 (9): 953&ndash, 954. doi:10.1016/S0040-4039(01)80071-X.
  • Okada N, Shinmyo A, Okada H, Yamada Y (1988). "Purification and characterization of (S)-tetrahydroberberine oxidase from cultured Coptis japonica cells". Phytochemistry. 27 (4): 979&ndash, 982. doi:10.1016/0031-9422(88)80255-3.