Timothy Ray Brown

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Timothy Ray Brown (born 1966) is an American considered to be the first person cured of HIV/AIDS.[1][2] Brown was diagnosed with HIV in 1995 while studying in Berlin, Germany, giving him the nickname The Berlin Patient.[3]

Procedure[edit]

In 2007, Brown, who was HIV positive, underwent a procedure known as hematopoietic stem cell transplantation to treat leukemia[4] (performed by a team of doctors in Berlin, Germany, including Gero Hütter). From 60 matching donors, they selected a [CCR5]-Δ32 homozygous individual with two genetic copies of a rare variant of a cell surface receptor. This genetic trait confers resistance to HIV infection by blocking attachment of HIV to the cell. Roughly 10% of people of European ancestry have this inherited mutation, but it is rarer in other populations.[5][6] The transplant was repeated a year later after a leukemia relapse. Over the three years after the initial transplant, and despite discontinuing antiretroviral therapy, researchers could not detect HIV in Brown's blood or in various biopsies.[7] Levels of HIV-specific antibodies in Timothy Brown's blood also declined, suggesting that functional HIV may have been eliminated from his body. However, scientists studying his case warn that this remission of HIV infection is unusual.[8]

Brown, the "Berlin patient", suffered from graft-versus-host disease and leukoencephalopathy – both transplant complications that are potentially fatal. This means that the procedure should not be performed on others with HIV, even if sufficient numbers of suitable donors could be found.[9][10] In fact, there is now some doubt that Timothy Brown's apparent cure was due to the unusual nature of the stem cells he received. The graft-versus-host disease Brown suffered from could have been what eliminated the HIV virus from his system.

As of 2017, six more people also appear to have been cleared of HIV after getting graft-versus-host disease; only one of them had received CCR5 mutant stem cells, so it appears that when a transplant recipient has graft-versus-host disease the transplanted cells may kill off the host's HIV-infected immune cells.[11]

Timothy Ray Brown Foundation[edit]

In July 2012, Brown announced the formation of the Timothy Ray Brown Foundation in Washington, DC, a foundation dedicated to fighting HIV/AIDS.[12]

See also[edit]

References[edit]

  1. ^ "ADULT Stem Cell Transplant Cures HIV-Positive Man, Say Docs". Fox Nation. Retrieved 2015-01-20. 
  2. ^ Trudy Ring (2012-09-07). "Is Anyone Immune to HIV?". HIVPlusMag. Retrieved 2015-01-20. 
  3. ^ Andre Picard (2012-07-24). "Meet the man who was cured of HIV". The Globe and Mail. Retrieved 2015-11-20. Mr. Brown, an American from Seattle, was attending school in Berlin in 1995 when he tested positive for HIV. 
  4. ^ "German HIV patient cured after stem cell transplant". Belfast Telegraph. 15 December 2010. Retrieved 15 December 2010. 
  5. ^ "Bone marrow 'cures HIV patient'". BBC News. 13 November 2008. Retrieved 2009-01-02. 
  6. ^ Novembre, J; Galvani, AP; Slatkin, M (2005). "The Geographic Spread of the CCR5 Δ32 HIV-Resistance Allele". PLoS Biology. 3 (11): e339. doi:10.1371/journal.pbio.0030339. PMC 1255740Freely accessible. PMID 16216086.  open access publication – free to read
  7. ^ Allers, K.; Hutter, G.; Hofmann, J.; Loddenkemper, C.; Rieger, K.; Thiel, E.; Schneider, T. (2010). "Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation". Blood. 117 (10): 2791–2799. doi:10.1182/blood-2010-09-309591. PMID 21148083. 
  8. ^ http://www.aidsmeds.com/articles/hiv_aids_stemcell_2042_14199.shtml
  9. ^ Levy JA (2009). "Not an HIV Cure, but Encouraging New Directions". N Engl J Med. 360 (7): 724–725. doi:10.1056/NEJMe0810248. PMID 19213687. Retrieved 2009-03-31. 
  10. ^ Lunzen, J.; Fehse, B.; Hauber, J. (2011). "Gene Therapy Strategies: Can We Eradicate HIV?". Current HIV/AIDS Reports. 8 (2): 78–84. doi:10.1007/s11904-011-0073-9. PMID 21331536. 
  11. ^ Clare Wilson (May 6, 2017). "Immune war with donor cells after transplant may wipe out HIV". New Scientist. 
  12. ^ "Man "cured" of AIDS: Timothy Ray Brown". CBSNews. Retrieved 2015-01-20.