Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trans-2,3-dihydro-3-hydroxyanthranilate isomerase (EC, phzF (gene)) is an enzyme with systematic name (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate

The enzyme is involved in phenazine biosynthesis.


  1. ^ Parsons, J.F.; Song, F.; Parsons, L.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79". Biochemistry. 43: 12427–12435. doi:10.1021/bi049059z. PMID 15449932. 
  2. ^ Blankenfeldt, W.; Kuzin, A.P.; Skarina, T.; Korniyenko, Y.; Tong, L.; Bayer, P.; Janning, P.; Thomashow, L.S.; Mavrodi, D.V. (2004). "Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens". Proc. Natl. Acad. Sci. USA. 101: 16431–16436. doi:10.1073/pnas.0407371101. PMC 534541Freely accessible. PMID 15545603. 
  3. ^ Parsons, J.F.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure of the phenazine biosynthesis enzyme PhzG". Acta Crystallogr. D. 60: 2110–2113. doi:10.1107/s0907444904022474. PMID 15502343. 
  4. ^ Mavrodi, D.V.; Bleimling, N.; Thomashow, L.S.; Blankenfeldt, W. (2004). "The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79". Acta Crystallogr. D. 60: 184–186. doi:10.1107/s090744490302571x. PMID 14684924. 
  5. ^ Ahuja, E.G.; Janning, P.; Mentel, M.; Graebsch, A.; Breinbauer, R.; Hiller, W.; Costisella, B.; Thomashow, L.S.; Mavrodi, D.V.; Blankenfeldt, W. (2008). "PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis". J. Am. Chem. Soc. 130: 17053–17061. doi:10.1021/ja806325k. PMID 19053436. 

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