Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

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Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
Identifiers
EC number 4.1.2.45
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (EC 4.1.2.45, 2'-hydroxybenzalpyruvate aldolase, NsaE, tHBPA hydratase-aldolase) is an enzyme with systematic name (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O salicylaldehyde + pyruvate

This enzyme is involved in naphthalene degradation.

References[edit]

  1. ^ Kuhm, A.E.; Knackmuss, H.J.; Stolz, A. (1993). "Purification and properties of 2′-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates". J. Biol. Chem. 268 (13): 9484–9489. PMID 8486638. 
  2. ^ Keck, A.; Conradt, D.; Mahler, A.; Stolz, A.; Mattes, R.; Klein, J. (2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152: 1929–1940. doi:10.1099/mic.0.28783-0. PMID 16804169. 
  3. ^ Eaton, R.W. (1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". J. Bacteriol. 176 (24): 7757–7762. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239Freely accessible. PMID 8002605. 
  4. ^ Eaton, R.W. (2000). "trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst". Appl. Environ. Microbiol. 66 (6): 2668–2672. doi:10.1128/aem.66.6.2668-2672.2000. PMC 110598Freely accessible. PMID 10831455. 

External links[edit]