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Transfersome is a trademark registered by the German company IDEA AG, which refers to its proprietary drug delivery technology. The name means “carrying body” and is derived from the Latin word 'transferre', meaning 'to carry across', and the Greek word 'soma', meaning 'a body'. A Transfersome carrier is an artificial vesicle designed to exhibit the characteristics of a cell vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially, targeted drug delivery.


The term Transfersome and the underlying concept were introduced in 1991 by Gregor Cevc. Numerous groups have since been working with similar carriers, frequently using different names (e.g., elastic vesicle, flexible vesicle, etc.) to describe them.

In a broader sense, a Transfersome is a highly adaptable, stress-responsive complex aggregate. The form preferred by researchers and pharmacologists is an ultradeformable vesicle possessing an aqueous core surrounded by the complex lipid bilayer. Interdependencies inherent in the local composition and shape of the bilayer makes the vesicle both self-regulating and self-optimizing. This enables the Transfersome to cross various transport barriers efficiently, and then act as a Drug carrier for non-invasive targeted drug delivery and sustained release of therapeutic agents.

Composition and mechanism of action[edit]

The carrier aggregate is composed of at least one amphiphat (such as phosphatidylcholine), which in aqueous solvents self-assembles into a lipid bilayer that closes into a simple lipid vesicle. By addition of at least one bilayer softening component (such as a biocompatible surfactant or an amphiphile drug) lipid bilayer flexibility and permeability are greatly increased. The resulting Transfersome is optimized for flexibility and permeability, and can therefore adapt its shape to ambient conditions easily and rapidly by adjusting local concentration of each bilayer component to the local stress experienced at the bilayer. Since its basic organization is broadly similar to a liposome, a Transfersome differs from more conventional vesicles primarily by its "softer", more deformable, and better adjustable artificial membrane.

Another beneficial consequence of strong bilayer deformability is the increased affinity of a Transfersome to bind and retain water. An ultradeformable and highly hydrophilic vesicle always tends to avoid dehydration, which may involve a transport process related to, but not identical with forward osmosis. For example, a Transfersome vesicle applied on an open biological surface, such as non-occluded skin, tends to penetrate its barrier and migrate into the water-rich deeper strata to secure adequate hydration. Barrier penetration involves reversible bilayer deformation, but must not compromise either vesicle integrity or barrier properties for the underlying hydration affinity and gradient to remain unimpaired.

Since it is too large to diffuse through the skin, the Transfersome must find and exploit a suitable route through the organ. Use of Transfersome vesicles for drug delivery therefore relies on the carrier’s ability to widen and overcome the hydrophilic pores in the skin or some other (e.g. plant cuticle) opening. The subsequent gradual release of the active agent from the drug carrier allows the drug molecules to diffuse and finally bind to their targets. Drug transport to an intra-cellular action site may also involve fusion of the carrier’s lipid bilayer with the cell membrane, unless the vesicle is taken up actively by the cell in the process called endocytosis.


The mechanical properties and transportability of a vesicle can be studied by measuring stress- or deformation-dependent vesicle bilayer elasticity and changes in permeability. In a single experiment, the objective may be reached by determining the pressure dependent area density of the Transfersome suspension flux through a nano-porous filter, with pores at least 50% smaller than the average vesicle size. For the proper Transfersome vesicles, the proportionality function derived by the experiment, so-called “Penetrability”, increases non-linearly with the flux driving force (head pressure), often sigmoidally). The bulk suspension viscosity governs the highest achievable penetrability; a suspension of ideal Transfersome vesicles, experiencing no friction in the barrier, therefore yields a similar maximum penetrability value as the comparably tested vesicles-suspending fluid. On the other hand, the characteristic pressure needed to achieve a significant transport rate with the vesicles suspension mainly depends on the adaptability of the bilayer being evaluated. Analysis of experimental Penetrability vs. Driving pressure curves can therefore yield the characteristic bilayer elasticity and permeability values, based on a theoretical description of material flow as an activated transport process.


Transfersome technology is best suited for non-invasive delivery of therapeutic molecules across open biological barriers where Transfersome vesicles can transport molecules that are too big to diffuse through the barrier. Examples include systemic delivery of therapeutically meaningful amounts of macromolecules, such as insulin or interferon, across intact mammalian skin. Other applications include the transport of small molecule drugs which have certain physicochemical properties which would otherwise prevent them from diffusing across the barrier.

Peripheral tissue targeting[edit]

Another attraction of Transfersome technology is the carrier's ability to target peripheral, subcutaneous tissue. This ability relies on minimisation of the carrier-associated drug clearance through cutaneous blood vessels plexus: the non-fenestrated blood capillary walls in the skin together with the tight junctions between endothelial cells preclude vesicles getting directly into blood, thus maximising local drug retention and propensity to reach the peripheral tissue targets. The Non-steroidal anti-inflammatory drug (NSAID) ketoprofen in a Transfersome formulation gained marketing approval by the Swiss regulatory agency (SwissMedic) in 2007; the product is expected to be marketed under the trademark Diractin. Further therapeutic products based on the Transfersome technology, according to IDEA AG, are in clinical development.


Transfersome vesicles are prepared in a similar manner as liposomes, except that no separation of the vesicle-associated and free drug is required. Examples include sonicating,[1] extrusion, low shear rates mixing (multilamellar liposomes), or high high-shear homogenisation unilamellar liposomes) of the crude vesicle suspension.


  1. ^ Stryer S. (1981) Biochemistry, 213

Further reading[edit]