Transportation in Ecuador uses six transportation methods to transport passengers and freight. They are aviation, pipelines and harbors, waterways Avianca LATAM Airlines TAME 359 total: 98 over 3,047 m: 3 2,438 to 3,047 m: 4 1,524 to 2,437 m: 19 914 to 1,523 m: 29 under 914 m: 43 total: 261 914 to 1,523 m:33 under 914 m:228 2 total: 43,197 kilometres paved: 6,467 kilometres unpaved: 36,730 kilometres The Sierra Region still plays an important role in transportation throughout the country; the Pan-American Highway crosses it from North to South. Ecuador has managed to update some roads into 4-lane freeways: Quito - Alpichacas. Length: 33 km. Guayaquil ring-road. Length: 46 km. Guayaquil - Taura. Length: 30 km. Guayaquil - Cerro Blanco. Length: 27 km. Machala - Pasaje. Length: 23 km. Bus transport in Ecuador crude oil 800 km petroleum products 1,358 km Esmeraldas Guayaquil, La Libertad Manta Puerto Bolívar San Lorenzo total: 31 ships totaling 184,819 GT/300,339 tonnes deadweight ships by type: Chemical tanker 1 gas carrying tanker 1 Passenger ships 7 Petroleum tankers 21 Specialized tanker 1Foreign-owned: 2 Norway 1, Paraguay 1Registered in other countries 1 Georgia 1 total: 812 km narrow gauge: 812 km 3 ft 6 in gauge There is a proposed rail connection with Colombia.

On 5 July 2008 a meeting took place between Venezuela and Ecuador regarding a railway for freight and passengers to link the three countries, linking the Pacific with the Atlantic also. There is no railway service to Peru. 1,500 kilometres This article incorporates public domain material from the CIA World Factbook website https://www.cia.gov/library/publications/the-world-factbook/index.html. Useful tips and articles about transportation in Ecuador

USS Robert E. Peary was an Edsall-class destroyer escort built for the U. S. Navy during World War II, she served in the Atlantic Ocean and provided destroyer escort protection against submarine and air attack for Navy vessels and convoys. She was named after Robert E. Peary, the famous Arctic explorer and laid down 30 June 1942 by the Consolidated Steel Co. Orange, Texas. Kerfoot B. Smith in command. Following shakedown off Bermuda, Robert E. Peary made her first run as a convoy escort to North Africa, arriving at Casablanca 13 August. By the end of the year, she had made two more runs to Casablanca, was returning to New York with her third westbound convoy. Early in 1944, Robert E. Peary crossed the Atlantic with a "hunter-killer" group, upon returning to the United States shifted to the northern sealanes. Between 28 March 1944 and 7 June 1945, she escorted 10 convoys to the United Kingdom and, after June 1944, to France. While returning to New York on 2 March 1945, Robert E. Peary and Hammann were diverted to aid two merchant ships which had collided.

After the destroyer escorts rescued survivors, Hammann stood by SS Lone Jack, while Robert E. Peary escorted SS Frontenac Victory to New York, arriving on the 6th. Ordered to the U. S. Pacific Fleet on completion of her last Atlantic Ocean run on 7 June 1945, Robert E. Peary underwent overhaul and was en route to the Pacific when the war with Japan ended. Redirected to New London, for duty with the Medical Research Department, she conducted binocular experiments proceeded to Green Cove Springs, Florida, she arrived in Florida on 11 January 1946 and decommissioned 13 June 1947. Transferred to the Norfolk, berthing area in 1959, she remained in the Atlantic Reserve Fleet until struck from the Navy list 1 July 1966, she was sold to Inc.. New York, New York, 6 September 1967. SS Robert E. Peary, a World War II Liberty ship with a similar name This article incorporates text from the public domain Dictionary of American Naval Fighting Ships; the entry can be found here. Dictionary of American Naval Fighting Ships NavSource Online: Destroyer Escort Photo Archive - USS Robert E. Peary

Hanggang sa Dulo ng Buhay Ko is a 2019 Philippine television drama horror series broadcast by GMA Network. Directed by Jorron Lee Monroy, it stars Rayver Cruz, Kim Domingo and Megan Young, it premiered on July 22, 2019 on the network's Afternoon Prime and Sabado Star Power sa Hapon line up replacing Dragon Lady. The series concluded on October 2019, with a total of 78 episodes, it was replaced by Magkaagaw in its timeslot. Titled as The Haunted Wife, it was renamed to Hanggang sa Dulo ng Buhay Ko. Yvie Cardeñas and Matteo Divinagracia are childhood sweethearts who fall in love and get married, they moved into their new family home, along with their adopted son and Yvie's cousin, Katya Calderon. Matteo's former girlfriend, Naomi Espiritu will disrupt their lives. Lead castKris Bernal as Naomi Espiritu Rayver Cruz as Matteo Divinagracia Kim Domingo as Katherine “Katya” De Jesus Calderon / Naomi Espiritu Megan Young as Yvette “Yvie” Cardeñas-DivinagraciaSupporting castBoots Anson-Roa as Adora "Abuela" Divinagracia Sharmaine Arnaiz as Valentina "Tina" De Jesus-Cardeñas Francine Prieto as Mercedes "Mercy" De Jesus-Calderon Beverly Salviejo as Vanessa "Vane" Espiritu Euwenn Aleta as Santino "Santy" Cardeñas Divinagracia / Matteo Espiritu Divinagracia Jr. Denise Barbacena as Brooke Analyn Barro as Tyra Joaquin Manansala as Paul Rob Moya as BobGuest castGileth Sandico as Mariana Patricia Javier as Loida Rodjun Cruz as Ben Patani Daño as Trinity Kevin Sagra as Carlson Hannah Precillas as Nina Boboy Garovillo as Daryl Rodolfo Muyuela as Kulas Patricia Tumulak as Michelle Rey PJ Abellana as Ross Cherry Malvar as Pearl Marlon Mance as Darius Bryan Benedict as Bustamante Visam Arenas as Gino Andrew Ferrer as Kicks According to AGB Nielsen Philippines' Nationwide Urban Television Audience Measurement People in television homes, the pilot episode of Hanggang sa Dulo ng Buhay Ko earned a 5% rating.

The series got its highest rating on July 2019 with a 5.7 % rating. Official website Hanggang sa Dulo ng Buhay Ko on IMDb

Glycogen synthase kinase 3 beta known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the GSK-3β gene. Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder. Glycogen synthase kinase-3 is a proline-directed serine-threonine kinase, identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, body pattern formation, it might be a new therapeutic target for ischemic stroke. Homozygous disruption of the GSK-3β locus in mice results in embryonic lethality during mid-gestation; this lethality phenotype could be rescued by inhibition of tumor necrosis factor. Two SNPs at this gene, rs334558 and rs3755557, are associated with efficacy of lithium treatment in bipolar disorder. Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis.

GSK3B has been shown to interact with: KIAA1211L Glycogen synthase kinase 3 PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycogen synthase kinase-3 beta

For the English journalist and crossword setter see Bob Smithies Robert Smithies was an English rugby league player who played in the 1960s and 1970s. Smithies came to Balmain from the Illawarra competition in 1969, he played three seasons with Balmain between 1969–1971, before moving to England to play for Hull KR for five years making 54 appearances plus 1 substitute appearance, scoring 22 tries for 66 points. Smithies won a premiership with Balmain. Smithies played fullback in Hull Kingston Rovers' 16–13 victory over Wakefield Trinity in the 1974 Yorkshire County Cup Final during the 1974–75 season at Headingley Rugby Stadium, Leeds on Saturday 26 October 1974. Smithies died on 5 November 2019, aged 71

Chad Greenway is a former American football linebacker who spent his entire 11-year career with the Minnesota Vikings of the National Football League. He played college football at Iowa, was drafted by the Vikings in the first round of the 2006 NFL Draft. Greenway attended Mount Vernon High School in Mount Vernon, South Dakota, where he was a three-time South Dakota All-state performer, earning first team honors as a junior and senior and third team honors as a sophomore, he was named Gatorade Football Player of the Year as a senior in 2001. Argus Leader and Sports Max Player of the Year, he earned first team All-conference honors for three straight seasons, as well as MVP honors. He played quarterback and free safety and returned punts and kickoffs, helping prep team win two consecutive state titles as a junior and senior, his career totals include 364 rushing 171-290 passes for 2,572 yards. On defense, he recorded 23 interceptions; as a senior, he completed 62-114 passes for 1,147 yards and rushed for 1,320 yards at quarterback, added 132 tackles and four interceptions at safety.

Greenway lettered in basketball and track & field at Mount Vernon. Greenway attended the University of Iowa, played for the Iowa Hawkeyes football team from 2002 to 2005, he redshirted his freshman season in 2001. As a redshirt freshman in 2002, he suffered a knee injury that required surgery and did not play in the first four games. In 2003, he was named second-team All-Big Ten. Greenway was named the Big Ten Conference co-Defensive Player of the Week vs. Arizona State, won the Hustle Team Award at Iowa. In 2004, he was named a first-team All-American by Pro Football Weekly, a second-team All-American by CNNSI.com, a third team All-American by CollegeSportsReport.com. Within the conference, Greenway was named first team All-Big Ten and selected as a first-team all-Big Ten player by Collegefootballnews.com. Greenway was selected by the team as Iowa's Special Teams Player of the Year, won the Hustle Team Award for defense, was one of three juniors selected to the team Leadership Council for 2004 season.

In 2005, Greenway was named preseason All-America by The Sporting News, NationalChamps.net, was named to the preseason honorable mention All-America squad selected by NationalChamps.net. He was ranked as the No. 2 outside linebacker by The Sporting News, named to the Bronko Nagurski and Lott Trophy watch lists. The Minnesota Vikings selected Greenway in the first round of the 2006 NFL Draft. Greenway was the third linebacker drafted in 2006, behind Ohio State's A. J. Hawk and Florida State's Ernie Sims. On July 23, 2006, the Minnesota Vikings signed Greenway to a five-year, $10.75 million contract that includes $6.14 million guaranteed. Throughout training camp, Greenway competed to be a starting outside linebacker against E. J. Henderson and Ben Leber. On August 14, 2006, Greenway tore his ACL in his left leg while covering a kickoff in the first quarter of the Vikings' 16–13 loss to the Oakland Raiders in their first preseason game, he subsequently missed his entire rookie season in 2006. The Minnesota Vikings hired Leslie Frazier as their new defensive coordinator after Mike Tomlin accepted the head coaching position with the Pittsburgh Steelers.

Greenway entered training camp slated as a starting outside linebacker. Head coach Brad Childress named Greenway the starting weakside linebacker to begin the regular season, alongside Ben Leber and middle linebacker E. J. Henderson, he made his professional regular season debut and first career start in the Minnesota Vikings' season-opener against the Atlanta Falcons and recorded ten combined tackles in their 24–3 victory. On November 18, 2007, he recorded seven combined tackles, a season-high two pass deflections, made his first career interception off a pass by quarterback Daunte Culpepper during a 29–22 victory against the Oakland Raiders in Week 11. In Week 12, Greenway made three solo tackles, a pass deflection, returned an interception for his first career touchdown in the Vikings' 41–17 win at the New York Giants. Greenway intercepted a pass by Giants' quarterback Eli Manning and returned it for a 37-yard touchdown in the fourth quarter. On December 9, 2007, he collected a season-high 13 combined tackles during a 27–7 victory at the San Francisco 49ers in Week 14.

Greenway started all 16 games in 2007 and recorded 105 combined tackles, four pass deflections, two forced fumbles, two interceptions, one touchdown. Head coach Brad Childress retained Greenway and Ben Leber as the starting outside linebackers in 2008, along with middle linebacker E. J. Henderson. On September 21, 2008, Greenway recorded nine combined tackles and made his first career sack on quarterback Jake Delhomme during a 20–10 win against the Carolina Panthers in Week 3. In Week 11, he collected a season-high 16 solo tackles, made a pass deflection, a sack in the Vikings' 13–10 loss at the Tampa Bay Buccaneers. In Week 15, Greenway recorded seven combined tackles, a season-high three pass deflections, a sack in a 35–14 win at the Arizona Cardinals. Greenway finished the 2008 season with 115 combined tackles, a career-high 5.5 sacks, five pass deflections in 16 games and 15 starts. The Minnesota Vikings finished first in the NFC North with a 10–6 record. On January 4, 2009, Greenway recorded ten combined tackles during the Vikings' 26–14 loss against the Philadelphia Eagles in the NFC Wildcard Game.

On September 20, 2009, Greenway recorded four combined tackles, deflected two passes, made a career-high two interceptions during a 27–13 victory at the Detroit Lions in Week 2. Gr