The Treaty of Fort Wayne, sometimes called the Ten O'clock Line Treaty or the Twelve Mile Line Treaty, is an 1809 treaty that obtained 29,719,530 acres of Native American land for the settlers of Illinois and Indiana. The negotiations primarily involved the Delaware tribe but included other tribes as well. However, the negotiations excluded the Shawnee, who were minor inhabitants of the area and had previously been asked to leave by Miami War Chief Little Turtle. Territorial Governor William Henry Harrison negotiated the treaty with the tribes. The treaty led to a war with the United States begun by Shawnee leader Tecumseh and other dissenting tribesmen in what came to be called "Tecumseh's War".

The Battle of Tippecanoe was fought on November 7, 1811, in Battle Ground, Indiana, between American forces led by then Governor William Henry Harrison of the Indiana Territory and tribal forces associated with Shawnee leader Tecumseh and his brother Tenskwatawa, leaders of a confederacy of various tribes who opposed European-American settlement of the American frontier. As tensions and violence increased, Governor Harrison marched with an army of about 1,000 men to attack the confederacy's headquarters at Prophetstown, near the confluence of the Tippecanoe River and the Wabash River.