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Triazolam

Triazolam is a central nervous system depressant tranquilizer in the triazolobenzodiazepine class. It possesses pharmacological properties similar to those of other benzodiazepines, but it is only used as a sedative to treat severe insomnia. In addition to the hypnotic properties, triazolam's amnesic, sedative and muscle relaxant properties are pronounced, as well. Due to its short half-life, triazolam is not effective for patients who experience frequent awakenings or early wakening. Triazolam was patented in 1970 and went on sale in the United States in 1982. Triazolam is used for short-term treatment of acute insomnia and circadian rhythm sleep disorders, including jet lag, it is an ideal benzodiazepine for this use because of its fast onset of action and short half-life. It puts a person to sleep for about 1.5 hours. Triazolam is sometimes used as an adjuvant in medical procedures requiring anesthesia or to reduce anxiety during brief events, such as MRI scans and nonsurgical dental procedures.

Triazolam is ineffective in maintaining sleep, due to its short half-life, with quazepam showing superiority. Triazolam is prescribed as a sleep aid for passengers travelling on short- to medium-duration flights. If this use is contemplated, the user avoiding the consumption of alcoholic beverages is important, as is trying a ground-based "rehearsal" of the medication to ensure that the side effects and potency of this medication are understood by the user prior to using it in a more public environment. Triazolam causes anterograde amnesia, why so many dentists administer it to patients undergoing minor dental procedures; this practice is known as sedation dentistry. Adverse drug reactions associated with the use of triazolam include: Relatively common: somnolence, feeling of lightness, coordination problems Less common: euphoria, tiredness, confusional states/memory impairment, cramps/pain, visual disturbances Rare: constipation, taste alteration, dry mouth, dermatitis/allergy, dreams/nightmares, parasthesia, dysesthesia, congestionTriazolam, although a short-acting benzodiazepine, may cause residual impairment into the next day the next morning.

A meta-analysis demonstrated that residual "hangover" effects after nighttime administration of triazolam such as sleepiness, psychomotor impairment, diminished cognitive functions may persist into the next day, which may impair the ability of users to drive safely and increase risks of falls and hip fractures. Confusion and amnesia have been reported. A 2009 meta-analysis found a 44% higher rate of mild infections, such as pharyngitis or sinusitis, in people taking triazolam or other hypnotic drugs compared to those taking a placebo. A review of the literature found that long-term use of benzodiazepines, including triazolam, is associated with drug tolerance, drug dependence, rebound insomnia, CNS-related adverse effects. Benzodiazepine hypnotics should be used at their lowest possible dose and for a short period of time. Nonpharmacological treatment options were found to yield sustained improvements in sleep quality. A worsening of insomnia compared to baseline may occur after discontinuation of triazolam following short-term, single-dose therapy.

Other withdrawal symptoms can range from mild unpleasant feelings to a major withdrawal syndrome, including stomach cramps, muscle cramps, tremor, in rare cases, convulsions. Benzodiazepines require special precautions if used in the elderly, during pregnancy, in children, in alcoholics, or in other drug-dependent individuals and individuals with comorbid psychiatric disorders. Triazolam belongs to the Pregnancy Category X of the FDA, it is known to have the potential to cause birth defects. Triazolam, similar to other benzodiazepines and nonbenzodiazepines, causes impairments in body balance and standing steadiness in individuals who wake up at night or the next morning. Falls and hip fractures are reported; the combination with alcohol increases these impairments. Partial, but incomplete tolerance develops to these impairments. Daytime withdrawal effects can occur. An extensive review of the medical literature regarding the management of insomnia and the elderly found considerable evidence of the effectiveness and durability of nondrug treatments for insomnia in adults of all ages and that these interventions are underused.

Compared with the benzodiazepines including triazolam, the nonbenzodiazepine sedative-hypnotics appeared to offer few, if any, significant clinical advantages in efficacy or tolerability in elderly persons. Newer agents with novel mechanisms of action and improved safety profiles, such as the melatonin agonists, hold promise for the management of chronic insomnia in elderly people. Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment, anterograde amnesia, daytime sedation, motor incoordination, increased risk of motor vehicle accidents and falls. One study found no evidence of sustained hypnotic efficacy throughout the 9 weeks of treatment for triazolam. In addition, the effectiveness and safety of long-term use of these agents remain to be determined. More research is needed to evaluate the long-term effects of treatment and the most appropriate management strategy for elderly persons with chronic insomnia.

Ketoconazole and itra

College of the Mainland

College of the Mainland is a public community college in Texas City, Texas. Its name comes from its location on the "mainland" portion of Texas; the school's sport teams are named the Fighting Ducks. College of the Mainland was launched in late 1966 when the voters of Dickinson, Hitchcock, La Marque, Santa Fe, Texas City approved a building-bond issue of $2,850,000, having been an idea since 1935. Herbert F. Stallworth, who had helped establish two colleges, was selected to head the new college in April 1967, Fred A. Taylor was appointed dean of instruction. Classes were begun in temporary quarters in 1967. On March 21, 1970, the administration building, learning-resources center and science building, technical-vocational building were completed, the College of the Mainland moved to its new campus on Palmer Highway. On May 16, 1970, residents of the college district approved $4,750,000 for a second phase of construction; the campus was expanded to include a fine arts building, a physical education complex, a student center.

The math-science and technical-vocational buildings were improved. In 1984 a third addition to the technical-vocational building was constructed. In 1991, two industrial education buildings were completed to house auto mechanics and diesel technology programs. In 1999, a new public service careers building opened to provide classrooms and labs for EMS, fire and police academies as well as housing the college's pharmacy technician program. In 2003, the college opened the COM Learning Center-North County in League City, part of COM's extended service area; the center is a leased facility that offers college credit and continuing education classes as well as dental assistant, medical assistant and other health care programs. In 2004, the college became one of only three in the state of Texas to offer a Collegiate High School program on its campus allowing high school students to complete their last two years on a college campus while earning an associate degree. In 2009, Dr. Michael A. Elam became the College's seventh president.

After months of contract renewal negotiations, Dr. Elam resigned in November 2011 in a $191,000 settlement that involves him going on sabbatical through November 2012. Larry Durrence was named interim president effective January 2012. Dr. Beth Lewis became president in 2013. Dr. Warren Nichols was named president on Jan. 30, 2017 and started Feb. 13, 2017. The college garnered national attention in 2002 when political science instructor and self-avowed Marxist David Michael Smith applied for tenure, prompting vocal opposition from some residents and another former professor, Howard Katz; the college president Ralph Holm as well as Smith's department and many former students supported Smith's application and he was granted tenure. In April 2010, the College of the Mainland, acting under President Michael Elam, sought to modify the way union fees were deducted from faculty pay. Smith and a number of concerned parties raised an issue with this change in policy. Smith, the president of the Faculty Union attended a subsequent board of trustees meeting and objected to the change.

After Elam reprimanded Smith, gave him a negative performance evaluation, removed from the hiring board Smith sued the college. In 2013, Smith was formally fired shortly thereafter. Besides traditional community college transfer classes, vocational programs and continuing education courses, such as those designed for students pursuing careers in nursing and business, the college offers a process technology degree for those seeking employment as operators in the refineries and other petroleum-related plants; as of 2017, student enrollment was 4,328. COM provides free GED and English as a second language classes to individuals at locations throughout Galveston County. Adult Basic Education courses are perfect for improving reading and mathematics skills and preparing for the General Education Development test; these nine-week courses are tuition free and have convenient schedules during morning, afternoon or evening hours. Students who complete this course and obtain their GED participate in a graduation ceremony.

English as a Second Language classes help students improve their ability to read, write and speak the English language. There is no minimum skill level required. Course are nine weeks; the tuition is free, no books are required. Students of all abilities can conveniently achieve their English language goals with College of the Mainland. COM offers a Collegiate High School, which allows students to earn an associate degree by high school graduation. Students can remain involved in extracurriculars at their home high school. Dual credit classes at the COM main campus at the COM Learning Center-North County in League City, or at the High School student's main campus, allow students to earn high school and college credit simultaneously. Upward Bound, a federally funded program, is open to students from low-income families, students who have disabilities or students who will be the first in their families to graduate from college; the program helps them with visits to universities and academic advising.

COM offers continuing education classes designed to help students pursue a new interest. The Hispanic and Latino population's percentage of the overall population of Texas City had increased to 29.9% in 2017 from 27% in 2010, as a result over 25% of the students at College of the Mainland are Hispanic or Latino as of 2019. COM students can participate in competitive club

Rue Saint-Séverin, Paris

The rue Saint-Séverin is a sometimes boisterous street running parallel to the river in the north of Paris' Latin Quarter. Lined with restaurants and souvenir shoppes, much of its commerce is dedicated to tourism. One of Paris' oldest churches, the Église Saint-Séverin, lies midway along this street's length; the rue Saint-Séverin is one of Paris' oldest streets, as it dates from its quarter's creation in the early 13th century. At first existing only between the rue de la Harpe and the rue Saint-Jacques, it was extended westwards from the former street to join the Rue Saint-André-des-Arts; the rue Saint-Séverin reclaimed the remnants of the ancient rue du Macon upon the construction of the boulevard Saint-Michel from 1867, but from 1971 this isolated westward portion was renamed the Rue Francisque-Gay. Former Names: Between the rue de la Harpe and the rue Saint-Jacques, this street was called the "rue Colin Pochet" in the 16th century. 7, 9, 11 - Buildings dating from the 17th century. 13 - Building still having its "name sign" that predated addresses - this one "Le Cygne de la Croix".

4 - Engraving of streetname on building corner. "St" scratched away. 6 - Alleyway existing in 1239. 8 - Door and alleyway dating from the 16th century. 20 - 17th-century "rotisserie". 22 - 17th century hotel. 24-26 - Street name engraved on building corners. 34 - Building dating from the 17th century. Remarkable doorway, arch engravings and stairway. 36 - Building known as l'auberge de "l'Étoile" in 1660. The Great Cat Massacre Hillairet, Jacques. Connaissance du Vieux Paris. Rivages. ISBN 2-86930-648-2. Mairie de Paris - "Nomenclature des Voies: rue Saint-Séverin". Retrieved February 17, 2006

South West Isle (Tasmania)

The South West Isle, part of the Kent Group, is an unpopulated 19.09-hectare granite island, located in the Bass Strait, lying off the north-east coast of Tasmania, between the Furneaux Group and Wilsons Promontory in Victoria, Australia. The island has a peak elevation of 120 metres and is contained within the Kent Group National Park, Tasmania's northernmost national park, gazetted in 2002. Recorded breeding seabird and waterbird species include little penguin, short-tailed shearwater, fairy prion, common diving-petrel, Pacific gull, silver gull, sooty oystercatcher and Cape Barren goose. Reptiles present are Bougainville's skink and White's skink. List of islands of Tasmania Protected areas of Tasmania Parks and Wildlife Service. "Kent Group National Park Management Plan 2005". Department of Tourism, Parks and the Arts. Hobart: Tasmanian Government. ISBN 0-9751743-4-7

Justin T. Moore

Justin Tatch Moore is a set theorist and logician. He is a full professor in mathematics at Cornell University. Moore received his PhD in 2000 from the University of Toronto under the supervision of Stevo Todorcevic, he was an assistant professor in mathematics at Boise State University. In the fall of 2007, he joined the faculty at Cornell University, his primary research area is Ramsey theory of infinite sets. He is known for solutions to the basis problem for uncountable linear orders and to the L space problem from general topology and for his work in determining the consequences of relating the continuum to certain values of the aleph function. Moore, together with his graduate and his PhD student Yash Lodha, solved the von Neumann-Day problem, first described by mathematician John von Neumann in 1929. Lodha presented this solution at the London Mathematical Society's Geometric and Cohomological Group Theory symposium in August 2013. Moore won the "Young Scholar's Competition" award in 2006, in Austria.

The Competition was a part of the "Horizons of Truth" celebrating the Gödel Centenary 2006. He was an invited speaker at the ICM, Hyderabad 2010, Logic session, where he presented his solution to the problem of constructing an L-space; the L-space was constructed without assuming additional axioms and by combining Todorcevic's rho functions with number theoryMoore is an editor for the Archive of Mathematical Logic where he handles papers in set theory. He was one of the organizers of the fall 2012 Thematic Program in Forcing and its Applications at the Fields Institute. In 2012, he was elected as a Fellow of the American Mathematical Society. Justin Tatch Moore Collected Works

Hayward House (Colchester, Connecticut)

The Hayward House is a historic house at 9 Hayward Avenue in Colchester, Connecticut. Built in 1775 and embellished in the late 19th century, it is a well-preserved 18th-century house, which has seen a number of locally prominent residents, as well as the nationally known inventor Nathaniel Hayward, who developed the process of vulcanizing rubber; the house was listed on the National Register of Historic Places in 1972. The Hayward House is located on the north side of Colchester's central village green, on the north side of Hayward Avenue, it is a three-story wood frame structure, with a gambrel roof, a large central chimney, a single-story porch extending across the front. The roof is pierced by three gabled dormers; the main facade is five bays wide, with a center entrance framed by pilasters and a corniced entablature. A series of ells extend to the rear. On the left side a single-story polygonal bay projects, a single-story screened porch extends across the right. During the late 19th-century, a Victorian porch was built across the front.

The house was built about 1775, by a local builder, for Dudley Wright. At the time of its construction, it was one of most elegant homes in the village. Wright operated a tavern on the premises, hosted meetings of the local Masonic lodge, which were held in a large ballroom that extends across the rear of the second floor. Dudley Wright's daughter married Doctor John Watrous, a figure locally prominent not just as a physician, but for his civic involvement and philanthropy. In 1842, the house was purchased by the 19th-century inventor Nathaniel Hayward, the founder and principal owner of the Hayward Rubber Company. National Register of Historic Places listings in New London County, Connecticut Historic American Buildings Survey No. CT-144, "Hayward House on Green, New London County, CT", 1 photo