Triphenylbromoethylene

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Triphenylbromoethylene
Triphenylbromoethylene.png
Clinical data
Trade names Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm
Synonyms Bromotriphenylethylene; Phenylstilbene bromide; Fenbrostilbenum
Drug class Nonsteroidal estrogen
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C20H15Br
Molar mass 335.244 g/mol
3D model (JSmol)

Triphenylbromoethylene (brand names Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm), also known as bromotriphenylethylene or as phenylstilbene bromide, is a synthetic nonsteroidal estrogen of the triphenylethylene group that was marketed in the 1940s similarly to the closely related estrogen triphenylchloroethylene.[1][2]

A diethoxylated derivative of triphenylbromoethylene, estrobin (DBE), is also an estrogen, but, in contrast, was never marketed.[3] An ethylated derivative of triphenylbromoethylene, broparestrol (BDPE), is a selective estrogen receptor modulator (SERM) that has been marketed.[4][5]

See also[edit]

References[edit]

  1. ^ Martin Negwer; Hans-Georg Scharnow (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 1861. ISBN 978-3-527-30247-5. C20H15Br. 1607-57-4. Bromotriphenylethene = Triphenylbromoethylene = Phenylstilbene bromide = 1,1',1"-(1-Bromo-1-ethenyl-2-yli- dene)tris[benzene] (•) S Bromylene, Fenbrostilbenum, Oestronyl, Phenylstilbene bromide, Prostilban, Tribenorm U Synthetic estrogen 
  2. ^ Paterson, E.; Gilbert, C. W.; Gallagher, U. M.; Hendry, J. A. (1949). "Metabolism of the Œstrogen Triphenyl-bromoethylene". Nature. 163 (4151): 801–802. doi:10.1038/163801a0. ISSN 0028-0836. 
  3. ^ C. W. Emmens (22 October 2013). Hormone Assay. Elsevier Science. pp. 394–. ISBN 978-1-4832-7286-3. 
  4. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 183–. ISBN 978-1-4757-2085-3. 
  5. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 139–. ISBN 978-3-88763-075-1.