UFC Fight Night: Cowboy vs. Cowboy was a mixed martial arts event held on February 21, 2016, at the Consol Energy Center in Pittsburgh, Pennsylvania.

Donald Anthony Cerrone, known professionally by his nickname "Cowboy", is an American former professional boxer, mixed martial artist, professional kickboxer and actor. He competed in the Lightweight and Welterweight divisions of the Ultimate Fighting Championship (UFC), and was known and respected by fans for his willingness to fight any time, having completed 38 fights in his 11 year UFC tenure. Cerrone was inducted into the UFC Hall of Fame in July 2023.