USS Bainbridge (DLGN-25/CGN-25) was a nuclear-powered guided missile cruiser in the United States Navy, the only ship of her class. Named in honor of Commodore William Bainbridge, she was the fourth US Navy ship to bear the name. With her original hull classification symbol of DLGN, she was the first nuclear-powered destroyer-type ship in the US Navy, and shared her name with the lead ship of the first US Navy destroyer class, the Bainbridge-class destroyers.

William Bainbridge was a commodore in the United States Navy. During his long career in the young American Navy he served under six presidents beginning with John Adams and is notable for his many victories at sea. He commanded several famous naval ships, including USS Constitution, and saw service in the Barbary Wars and the War of 1812. Bainbridge was also in command of USS Philadelphia when she grounded off the shores of Tripoli, Libya in North Africa, resulting in his capture and imprisonment for many months. In the latter part of his career he became the U.S. Naval Commissioner.