USS Davis (DD-65) was a Sampson-class destroyer in commission in the United States Navy from 1916 to 1922. She saw service during World War I. She was the second Navy ship named for Rear Admiral Charles Henry Davis (1807–1877).

The Sampson-class destroyers served in the United States Navy during World War I. Commissioned in 1916 and 1917, the class was a modification of the O'Brien and Tucker classes, with the number of 21-inch (533 mm) torpedo tubes increased from four twin-mounts to four triple-mounts. The Sampsons were the final six ships of the 26 "thousand tonner" destroyers. They were the largest and most heavily armed of the "thousand tonners", and the subsequent "flush deck" classes differed mainly in hull design and the engineering plant.